Extramedullary blast transformation as the initial presentation of Chronic Myeloid Leukemia with bone marrow remaining in the chronic phase is an unusual event. We report the case of a 30-year-old with chronic CML at the medullary level and an acute transformation revealed by extensive bone lyses and skin lesions. A 30-year-old man had cutaneous nodules, functional impotence and paresis. Radiological investigations revealed osteolytic lesions of the right humeral head, right clavicle, ribs, C5 and C7 vertebrae with medullary compression. Anatomo-pathological study and immunohistochemistry of nodules and osteolytic lesions resulted in granulocytic sarcoma with CD10 +, CD34 +, CD13 +, CD33 +, CD117 and MPO positive. The myelogram was in favor of chronic phase CML. He was put on imatinib, the chemotherapy could not be started because his condition was impaired and he dies by metabolic disorder. The acute transformation of chronic phase CML into extra marrow remains unusual. The care is a real challenge hence the need for consensual recommendations.
Published in | Cancer Research Journal (Volume 6, Issue 2) |
DOI | 10.11648/j.crj.20180602.15 |
Page(s) | 70-73 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2018. Published by Science Publishing Group |
Acute Transformation, Chronic Myeloid Leukemia, Bones lesions, Skin Lesions
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APA Style
Bienvenu Houssou, Mouna Lamchahab, Halima Hadri, Boubker Messoudi, Abdeljabbar Messoudi, et al. (2018). Extensive Bone Lesions and Skin Lesions Revealing an Acute Transformation of an Extramedullary Chronic Myeloid Leukemia. Cancer Research Journal, 6(2), 70-73. https://doi.org/10.11648/j.crj.20180602.15
ACS Style
Bienvenu Houssou; Mouna Lamchahab; Halima Hadri; Boubker Messoudi; Abdeljabbar Messoudi, et al. Extensive Bone Lesions and Skin Lesions Revealing an Acute Transformation of an Extramedullary Chronic Myeloid Leukemia. Cancer Res. J. 2018, 6(2), 70-73. doi: 10.11648/j.crj.20180602.15
AMA Style
Bienvenu Houssou, Mouna Lamchahab, Halima Hadri, Boubker Messoudi, Abdeljabbar Messoudi, et al. Extensive Bone Lesions and Skin Lesions Revealing an Acute Transformation of an Extramedullary Chronic Myeloid Leukemia. Cancer Res J. 2018;6(2):70-73. doi: 10.11648/j.crj.20180602.15
@article{10.11648/j.crj.20180602.15, author = {Bienvenu Houssou and Mouna Lamchahab and Halima Hadri and Boubker Messoudi and Abdeljabbar Messoudi and Asma Quessar}, title = {Extensive Bone Lesions and Skin Lesions Revealing an Acute Transformation of an Extramedullary Chronic Myeloid Leukemia}, journal = {Cancer Research Journal}, volume = {6}, number = {2}, pages = {70-73}, doi = {10.11648/j.crj.20180602.15}, url = {https://doi.org/10.11648/j.crj.20180602.15}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20180602.15}, abstract = {Extramedullary blast transformation as the initial presentation of Chronic Myeloid Leukemia with bone marrow remaining in the chronic phase is an unusual event. We report the case of a 30-year-old with chronic CML at the medullary level and an acute transformation revealed by extensive bone lyses and skin lesions. A 30-year-old man had cutaneous nodules, functional impotence and paresis. Radiological investigations revealed osteolytic lesions of the right humeral head, right clavicle, ribs, C5 and C7 vertebrae with medullary compression. Anatomo-pathological study and immunohistochemistry of nodules and osteolytic lesions resulted in granulocytic sarcoma with CD10 +, CD34 +, CD13 +, CD33 +, CD117 and MPO positive. The myelogram was in favor of chronic phase CML. He was put on imatinib, the chemotherapy could not be started because his condition was impaired and he dies by metabolic disorder. The acute transformation of chronic phase CML into extra marrow remains unusual. The care is a real challenge hence the need for consensual recommendations.}, year = {2018} }
TY - JOUR T1 - Extensive Bone Lesions and Skin Lesions Revealing an Acute Transformation of an Extramedullary Chronic Myeloid Leukemia AU - Bienvenu Houssou AU - Mouna Lamchahab AU - Halima Hadri AU - Boubker Messoudi AU - Abdeljabbar Messoudi AU - Asma Quessar Y1 - 2018/05/05 PY - 2018 N1 - https://doi.org/10.11648/j.crj.20180602.15 DO - 10.11648/j.crj.20180602.15 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 70 EP - 73 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20180602.15 AB - Extramedullary blast transformation as the initial presentation of Chronic Myeloid Leukemia with bone marrow remaining in the chronic phase is an unusual event. We report the case of a 30-year-old with chronic CML at the medullary level and an acute transformation revealed by extensive bone lyses and skin lesions. A 30-year-old man had cutaneous nodules, functional impotence and paresis. Radiological investigations revealed osteolytic lesions of the right humeral head, right clavicle, ribs, C5 and C7 vertebrae with medullary compression. Anatomo-pathological study and immunohistochemistry of nodules and osteolytic lesions resulted in granulocytic sarcoma with CD10 +, CD34 +, CD13 +, CD33 +, CD117 and MPO positive. The myelogram was in favor of chronic phase CML. He was put on imatinib, the chemotherapy could not be started because his condition was impaired and he dies by metabolic disorder. The acute transformation of chronic phase CML into extra marrow remains unusual. The care is a real challenge hence the need for consensual recommendations. VL - 6 IS - 2 ER -