Treatment Efficiency and Problems of Local Control in Localized Bladder/Prostate Rhabdomyosarcoma

Hanafy Hafez; Enas El Nadi; Alaa Younes; Gehad Ahmed; Mohamed Saad Zaghloul; Hala Taha; Rania Labib; Sayed Abdelhamid Fadel; Soha Ahmed

doi:doi:10.11648/j.crj.20190702.11

Treatment Efficiency and Problems of Local Control in Localized Bladder/Prostate Rhabdomyosarcoma

Hanafy Hafez, Enas El Nadi, Alaa Younes, Gehad Ahmed, Mohamed Saad Zaghloul, Hala Taha, Rania Labib, Sayed Abdelhamid Fadel, Soha Ahmed

Published in Cancer Research Journal (Volume 7, Issue 2)

Received: 19 February 2019 Accepted: 22 March 2019 Published: 18 April 2019

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Abstract

Objectives: To assess the treatment efficiency, outcome and factors affecting the local control of localized bladder/prostate RMS. Patients and methods: Retrospective analysis of 54 patients with localized bladder/prostate RMS treated at Children Cancer Hospital, Egypt between August 2007 and Jan 2017. All patients were treated according to Intergroup Rhabdomyosarcoma Study (IRS -V) and subsequent Children’s Oncology Group COG guidelines. Results: The median age at diagnosis was 3.28 years (range 0.4–13.6). Fifty-one patients (94%) underwent initial biopsy. Complete surgical resection (primary or delayed) was performed in 7 patients (13%). Local control started before/at week 12 in 29 patients (61.7%). Local control methods were: Radiotherapy in 43 patients (79.2%), radiotherapy with surgery in 4 patients (9%), surgery in 1 patient and four patients did not receive local control. With a median follow up of 38.12 months, the 5-year failure-free survival (FFS) and overall (OS) of the whole patients were 60.4 ± 14.5% and 75.4 ± 14.1% respectively. A better 5-year FFS was experienced by those who had early local control (79.2 ± 17% vs. 43.8 ± 25% p= 0.005). Conclusions: Timing of local control and local radiotherapy is crucial and shouldn’t be delayed waiting for further response to the systemic chemotherapy.

Published in	Cancer Research Journal (Volume 7, Issue 2)
DOI	10.11648/j.crj.20190702.11
Page(s)	33-38
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

RMS, Bladder/Prostate, Local Control

References

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APA Style

Hanafy Hafez, Enas El Nadi, Alaa Younes, Gehad Ahmed, Mohamed Saad Zaghloul, et al. (2019). Treatment Efficiency and Problems of Local Control in Localized Bladder/Prostate Rhabdomyosarcoma. Cancer Research Journal, 7(2), 33-38. https://doi.org/10.11648/j.crj.20190702.11

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ACS Style

Hanafy Hafez; Enas El Nadi; Alaa Younes; Gehad Ahmed; Mohamed Saad Zaghloul, et al. Treatment Efficiency and Problems of Local Control in Localized Bladder/Prostate Rhabdomyosarcoma. Cancer Res. J. 2019, 7(2), 33-38. doi: 10.11648/j.crj.20190702.11

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AMA Style

Hanafy Hafez, Enas El Nadi, Alaa Younes, Gehad Ahmed, Mohamed Saad Zaghloul, et al. Treatment Efficiency and Problems of Local Control in Localized Bladder/Prostate Rhabdomyosarcoma. Cancer Res J. 2019;7(2):33-38. doi: 10.11648/j.crj.20190702.11

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@article{10.11648/j.crj.20190702.11,
  author = {Hanafy Hafez and Enas El Nadi and Alaa Younes and Gehad Ahmed and Mohamed Saad Zaghloul and Hala Taha and Rania Labib and Sayed Abdelhamid Fadel and Soha Ahmed},
  title = {Treatment Efficiency and Problems of Local Control in Localized Bladder/Prostate Rhabdomyosarcoma},
  journal = {Cancer Research Journal},
  volume = {7},
  number = {2},
  pages = {33-38},
  doi = {10.11648/j.crj.20190702.11},
  url = {https://doi.org/10.11648/j.crj.20190702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20190702.11},
  abstract = {Objectives: To assess the treatment efficiency, outcome and factors affecting the local control of localized bladder/prostate RMS. Patients and methods: Retrospective analysis of 54 patients with localized bladder/prostate RMS treated at Children Cancer Hospital, Egypt between August 2007 and Jan 2017. All patients were treated according to Intergroup Rhabdomyosarcoma Study (IRS -V) and subsequent Children’s Oncology Group COG guidelines. Results: The median age at diagnosis was 3.28 years (range 0.4–13.6). Fifty-one patients (94%) underwent initial biopsy. Complete surgical resection (primary or delayed) was performed in 7 patients (13%). Local control started before/at week 12 in 29 patients (61.7%). Local control methods were: Radiotherapy in 43 patients (79.2%), radiotherapy with surgery in 4 patients (9%), surgery in 1 patient and four patients did not receive local control. With a median follow up of 38.12 months, the 5-year failure-free survival (FFS) and overall (OS) of the whole patients were 60.4 ± 14.5% and 75.4 ± 14.1% respectively. A better 5-year FFS was experienced by those who had early local control (79.2 ± 17% vs. 43.8 ± 25% p= 0.005). Conclusions: Timing of local control and local radiotherapy is crucial and shouldn’t be delayed waiting for further response to the systemic chemotherapy.},
 year = {2019}
}

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TY - JOUR
T1 - Treatment Efficiency and Problems of Local Control in Localized Bladder/Prostate Rhabdomyosarcoma
AU - Hanafy Hafez
AU - Enas El Nadi
AU - Alaa Younes
AU - Gehad Ahmed
AU - Mohamed Saad Zaghloul
AU - Hala Taha
AU - Rania Labib
AU - Sayed Abdelhamid Fadel
AU - Soha Ahmed
Y1 - 2019/04/18
PY - 2019
N1 - https://doi.org/10.11648/j.crj.20190702.11
DO - 10.11648/j.crj.20190702.11
T2 - Cancer Research Journal
JF - Cancer Research Journal
JO - Cancer Research Journal
SP - 33
EP - 38
PB - Science Publishing Group
SN - 2330-8214
UR - https://doi.org/10.11648/j.crj.20190702.11
AB - Objectives: To assess the treatment efficiency, outcome and factors affecting the local control of localized bladder/prostate RMS. Patients and methods: Retrospective analysis of 54 patients with localized bladder/prostate RMS treated at Children Cancer Hospital, Egypt between August 2007 and Jan 2017. All patients were treated according to Intergroup Rhabdomyosarcoma Study (IRS -V) and subsequent Children’s Oncology Group COG guidelines. Results: The median age at diagnosis was 3.28 years (range 0.4–13.6). Fifty-one patients (94%) underwent initial biopsy. Complete surgical resection (primary or delayed) was performed in 7 patients (13%). Local control started before/at week 12 in 29 patients (61.7%). Local control methods were: Radiotherapy in 43 patients (79.2%), radiotherapy with surgery in 4 patients (9%), surgery in 1 patient and four patients did not receive local control. With a median follow up of 38.12 months, the 5-year failure-free survival (FFS) and overall (OS) of the whole patients were 60.4 ± 14.5% and 75.4 ± 14.1% respectively. A better 5-year FFS was experienced by those who had early local control (79.2 ± 17% vs. 43.8 ± 25% p= 0.005). Conclusions: Timing of local control and local radiotherapy is crucial and shouldn’t be delayed waiting for further response to the systemic chemotherapy.
VL - 7
IS - 2
ER -

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Author Information

Hanafy Hafez

Pediatric Oncology, National Cancer Institute (NCI), Cairo University, Cairo, Egypt
Enas El Nadi

Pediatric Oncology Department, Beni Suef University, Beni Suef, Egypt
Alaa Younes

Surgical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt
Gehad Ahmed

Surgery Department, Faculty of Medicine, Helwan University, Helwan, Egypt
Mohamed Saad Zaghloul

Radiation Oncology, National Cancer Institute (NCI), Cairo University, Cairo, Egypt
Hala Taha

Surgical Pathology, National Cancer Institute (NCI), Cairo University, Cairo, Egypt
Rania Labib

Clinical Research Department, Children Cancer Hospital Egypt, Cairo, Egypt
Sayed Abdelhamid Fadel

Pediatric Oncology, National Cancer Institute (NCI), Cairo University, Cairo, Egypt
Soha Ahmed

Department of Clinical Oncology, Aswan University, CCHE, Cairo, Egypt

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APA Style

Hanafy Hafez, Enas El Nadi, Alaa Younes, Gehad Ahmed, Mohamed Saad Zaghloul, et al. (2019). Treatment Efficiency and Problems of Local Control in Localized Bladder/Prostate Rhabdomyosarcoma. Cancer Research Journal, 7(2), 33-38. https://doi.org/10.11648/j.crj.20190702.11

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ACS Style

Hanafy Hafez; Enas El Nadi; Alaa Younes; Gehad Ahmed; Mohamed Saad Zaghloul, et al. Treatment Efficiency and Problems of Local Control in Localized Bladder/Prostate Rhabdomyosarcoma. Cancer Res. J. 2019, 7(2), 33-38. doi: 10.11648/j.crj.20190702.11

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AMA Style

Hanafy Hafez, Enas El Nadi, Alaa Younes, Gehad Ahmed, Mohamed Saad Zaghloul, et al. Treatment Efficiency and Problems of Local Control in Localized Bladder/Prostate Rhabdomyosarcoma. Cancer Res J. 2019;7(2):33-38. doi: 10.11648/j.crj.20190702.11

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@article{10.11648/j.crj.20190702.11,
  author = {Hanafy Hafez and Enas El Nadi and Alaa Younes and Gehad Ahmed and Mohamed Saad Zaghloul and Hala Taha and Rania Labib and Sayed Abdelhamid Fadel and Soha Ahmed},
  title = {Treatment Efficiency and Problems of Local Control in Localized Bladder/Prostate Rhabdomyosarcoma},
  journal = {Cancer Research Journal},
  volume = {7},
  number = {2},
  pages = {33-38},
  doi = {10.11648/j.crj.20190702.11},
  url = {https://doi.org/10.11648/j.crj.20190702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20190702.11},
  abstract = {Objectives: To assess the treatment efficiency, outcome and factors affecting the local control of localized bladder/prostate RMS. Patients and methods: Retrospective analysis of 54 patients with localized bladder/prostate RMS treated at Children Cancer Hospital, Egypt between August 2007 and Jan 2017. All patients were treated according to Intergroup Rhabdomyosarcoma Study (IRS -V) and subsequent Children’s Oncology Group COG guidelines. Results: The median age at diagnosis was 3.28 years (range 0.4–13.6). Fifty-one patients (94%) underwent initial biopsy. Complete surgical resection (primary or delayed) was performed in 7 patients (13%). Local control started before/at week 12 in 29 patients (61.7%). Local control methods were: Radiotherapy in 43 patients (79.2%), radiotherapy with surgery in 4 patients (9%), surgery in 1 patient and four patients did not receive local control. With a median follow up of 38.12 months, the 5-year failure-free survival (FFS) and overall (OS) of the whole patients were 60.4 ± 14.5% and 75.4 ± 14.1% respectively. A better 5-year FFS was experienced by those who had early local control (79.2 ± 17% vs. 43.8 ± 25% p= 0.005). Conclusions: Timing of local control and local radiotherapy is crucial and shouldn’t be delayed waiting for further response to the systemic chemotherapy.},
 year = {2019}
}

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