Acute lymphoblastic leukaemia is the most common malignancy in paediatric patients; its diagnosis is usually easy to establish as malignant lymphoblasts invade the bone marrow and peripheral blood. Patients with Acute lymphoblastic leukaemia (ALL) may initially present with pancytopenia and a hypoplastic or hyperplastic bone marrow. Fever is common at presentation, and despite neutropenia, sepsis is rarely seen. Other common clinical manifestations include fatigue, pallor, petechiae, bleeding, lymphadenopathy and hepatosplenomegaly. Presentation with primarily testicular disease is exceedingly rare in acute lymphoblastic leukemia. The unusual presentation of a primary left testicular involvement in ALL is being highlighted in this case report. We present an 11 year old boy who presented with fever, generalized body pain, abdominal discomfort as well as left testicular swelling. Bone marrow studies, Full blood count and peripheral blood film appearance were typical of acute lymphoblastic leukaemia. Ultrasound findings showed left scrotal enlargement with reduced and coarse parenchymal echotexture, while cytogenetic studies revealed positive Philadelphia chromosomes. There was good response to standard ALL therapy. Clinical remission with normal left testicular size was noted at the end of induction phase of therapy.
| Published in | Cancer Research Journal (Volume 8, Issue 2) |
| DOI | 10.11648/j.crj.20200802.14 |
| Page(s) | 42-44 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2020. Published by Science Publishing Group |
Acute Lymphoblastic Leukemia, Positive Philadelphia Chromosomes, Left Testicular Enlargement
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APA Style
Patrick Olanrewaju Osho, Matilda Adesuwa Osagie Ojo, Eevenly Salawa Osho, Olufunke Caroline Odunlade, Oluwatosin Idowu Oni. (2020). Acute Lymphoblastic Leukemia with Primary Testicular Involvement in a Pre-pubertal Male: A Case Report. Cancer Research Journal, 8(2), 42-44. https://doi.org/10.11648/j.crj.20200802.14
ACS Style
Patrick Olanrewaju Osho; Matilda Adesuwa Osagie Ojo; Eevenly Salawa Osho; Olufunke Caroline Odunlade; Oluwatosin Idowu Oni. Acute Lymphoblastic Leukemia with Primary Testicular Involvement in a Pre-pubertal Male: A Case Report. Cancer Res. J. 2020, 8(2), 42-44. doi: 10.11648/j.crj.20200802.14
AMA Style
Patrick Olanrewaju Osho, Matilda Adesuwa Osagie Ojo, Eevenly Salawa Osho, Olufunke Caroline Odunlade, Oluwatosin Idowu Oni. Acute Lymphoblastic Leukemia with Primary Testicular Involvement in a Pre-pubertal Male: A Case Report. Cancer Res J. 2020;8(2):42-44. doi: 10.11648/j.crj.20200802.14
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Download@article{10.11648/j.crj.20200802.14,
author = {Patrick Olanrewaju Osho and Matilda Adesuwa Osagie Ojo and Eevenly Salawa Osho and Olufunke Caroline Odunlade and Oluwatosin Idowu Oni},
title = {Acute Lymphoblastic Leukemia with Primary Testicular Involvement in a Pre-pubertal Male: A Case Report},
journal = {Cancer Research Journal},
volume = {8},
number = {2},
pages = {42-44},
doi = {10.11648/j.crj.20200802.14},
url = {https://doi.org/10.11648/j.crj.20200802.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20200802.14},
abstract = {Acute lymphoblastic leukaemia is the most common malignancy in paediatric patients; its diagnosis is usually easy to establish as malignant lymphoblasts invade the bone marrow and peripheral blood. Patients with Acute lymphoblastic leukaemia (ALL) may initially present with pancytopenia and a hypoplastic or hyperplastic bone marrow. Fever is common at presentation, and despite neutropenia, sepsis is rarely seen. Other common clinical manifestations include fatigue, pallor, petechiae, bleeding, lymphadenopathy and hepatosplenomegaly. Presentation with primarily testicular disease is exceedingly rare in acute lymphoblastic leukemia. The unusual presentation of a primary left testicular involvement in ALL is being highlighted in this case report. We present an 11 year old boy who presented with fever, generalized body pain, abdominal discomfort as well as left testicular swelling. Bone marrow studies, Full blood count and peripheral blood film appearance were typical of acute lymphoblastic leukaemia. Ultrasound findings showed left scrotal enlargement with reduced and coarse parenchymal echotexture, while cytogenetic studies revealed positive Philadelphia chromosomes. There was good response to standard ALL therapy. Clinical remission with normal left testicular size was noted at the end of induction phase of therapy.},
year = {2020}
}
TY - JOUR T1 - Acute Lymphoblastic Leukemia with Primary Testicular Involvement in a Pre-pubertal Male: A Case Report AU - Patrick Olanrewaju Osho AU - Matilda Adesuwa Osagie Ojo AU - Eevenly Salawa Osho AU - Olufunke Caroline Odunlade AU - Oluwatosin Idowu Oni Y1 - 2020/07/04 PY - 2020 N1 - https://doi.org/10.11648/j.crj.20200802.14 DO - 10.11648/j.crj.20200802.14 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 42 EP - 44 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20200802.14 AB - Acute lymphoblastic leukaemia is the most common malignancy in paediatric patients; its diagnosis is usually easy to establish as malignant lymphoblasts invade the bone marrow and peripheral blood. Patients with Acute lymphoblastic leukaemia (ALL) may initially present with pancytopenia and a hypoplastic or hyperplastic bone marrow. Fever is common at presentation, and despite neutropenia, sepsis is rarely seen. Other common clinical manifestations include fatigue, pallor, petechiae, bleeding, lymphadenopathy and hepatosplenomegaly. Presentation with primarily testicular disease is exceedingly rare in acute lymphoblastic leukemia. The unusual presentation of a primary left testicular involvement in ALL is being highlighted in this case report. We present an 11 year old boy who presented with fever, generalized body pain, abdominal discomfort as well as left testicular swelling. Bone marrow studies, Full blood count and peripheral blood film appearance were typical of acute lymphoblastic leukaemia. Ultrasound findings showed left scrotal enlargement with reduced and coarse parenchymal echotexture, while cytogenetic studies revealed positive Philadelphia chromosomes. There was good response to standard ALL therapy. Clinical remission with normal left testicular size was noted at the end of induction phase of therapy. VL - 8 IS - 2 ER -
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