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Ewing Sarcoma/Peripheral Neuroectodermal Tumor of Bone and Soft Tissue in Infants: A Report from Children Cancer Hospital of Egypt

Received: 22 December 2020     Accepted: 11 January 2021     Published: 25 January 2021
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Abstract

Introduction: Ewing sarcoma is an aggressive malignancy of bone and soft tissue. It is rare in children under age 5years. Ewing's sarcoma family tumors include classic Ewing’s sarcoma, primitive neuroectodermal tumour and Askin tumor ES is the second most common variety of primary bone cancer in adolescents and young adults. The treatment strategy for ES is characterized by multi-disciplinary collaboration between pediatric oncologists, medical oncologists, radiation oncologists, and orthopedic surgeons. Although the survival rate of ES patients has improved, their prognosis remains unsatisfactory, and the treatment of ES is still challenging specially in age group below 3 years. Patients and methods: A Retrospective study of children below 3 years with a diagnosis Ewing Sarcoma/PNET treated at our CCHE from July 2009 till December 2018. Results: A review of 46 patients with age ranged from 3 months to 3 years, Mean of age was 1.8. Primary site was Osseous and extraosseus in 23 infant patients for each. Main site was mainly axial in 28 cases (60.8%). Cases were treated according to COG protocol. Infantile Ewing sarcoma OS and EFS at 5-years OS were 75.5% and 66.7%. Conclusion: Patients below 3 years represent an unusually young age group. Conclusion: ES/PNET in age below 3 years is a unique age group with a different management and outcome.

Published in Cancer Research Journal (Volume 9, Issue 1)
DOI 10.11648/j.crj.20210901.13
Page(s) 14-22
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Ewing Sarcoma, Survival, Infants

References
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  • APA Style

    Enas El Nadi, Ahmed El Ghoneimy, Maged El Shafiey, Hala Taha, Mohamed Saad Zaghlool, et al. (2021). Ewing Sarcoma/Peripheral Neuroectodermal Tumor of Bone and Soft Tissue in Infants: A Report from Children Cancer Hospital of Egypt. Cancer Research Journal, 9(1), 14-22. https://doi.org/10.11648/j.crj.20210901.13

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    ACS Style

    Enas El Nadi; Ahmed El Ghoneimy; Maged El Shafiey; Hala Taha; Mohamed Saad Zaghlool, et al. Ewing Sarcoma/Peripheral Neuroectodermal Tumor of Bone and Soft Tissue in Infants: A Report from Children Cancer Hospital of Egypt. Cancer Res. J. 2021, 9(1), 14-22. doi: 10.11648/j.crj.20210901.13

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    AMA Style

    Enas El Nadi, Ahmed El Ghoneimy, Maged El Shafiey, Hala Taha, Mohamed Saad Zaghlool, et al. Ewing Sarcoma/Peripheral Neuroectodermal Tumor of Bone and Soft Tissue in Infants: A Report from Children Cancer Hospital of Egypt. Cancer Res J. 2021;9(1):14-22. doi: 10.11648/j.crj.20210901.13

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  • @article{10.11648/j.crj.20210901.13,
      author = {Enas El Nadi and Ahmed El Ghoneimy and Maged El Shafiey and Hala Taha and Mohamed Saad Zaghlool and Iman Zaki and Nehal Kamal and Nada Mounir and Manal Amin},
      title = {Ewing Sarcoma/Peripheral Neuroectodermal Tumor of Bone and Soft Tissue in Infants: A Report from Children Cancer Hospital of Egypt},
      journal = {Cancer Research Journal},
      volume = {9},
      number = {1},
      pages = {14-22},
      doi = {10.11648/j.crj.20210901.13},
      url = {https://doi.org/10.11648/j.crj.20210901.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20210901.13},
      abstract = {Introduction: Ewing sarcoma is an aggressive malignancy of bone and soft tissue. It is rare in children under age 5years. Ewing's sarcoma family tumors include classic Ewing’s sarcoma, primitive neuroectodermal tumour and Askin tumor ES is the second most common variety of primary bone cancer in adolescents and young adults. The treatment strategy for ES is characterized by multi-disciplinary collaboration between pediatric oncologists, medical oncologists, radiation oncologists, and orthopedic surgeons. Although the survival rate of ES patients has improved, their prognosis remains unsatisfactory, and the treatment of ES is still challenging specially in age group below 3 years. Patients and methods: A Retrospective study of children below 3 years with a diagnosis Ewing Sarcoma/PNET treated at our CCHE from July 2009 till December 2018. Results: A review of 46 patients with age ranged from 3 months to 3 years, Mean of age was 1.8. Primary site was Osseous and extraosseus in 23 infant patients for each. Main site was mainly axial in 28 cases (60.8%). Cases were treated according to COG protocol. Infantile Ewing sarcoma OS and EFS at 5-years OS were 75.5% and 66.7%. Conclusion: Patients below 3 years represent an unusually young age group. Conclusion: ES/PNET in age below 3 years is a unique age group with a different management and outcome.},
     year = {2021}
    }
    

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    AU  - Enas El Nadi
    AU  - Ahmed El Ghoneimy
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    AB  - Introduction: Ewing sarcoma is an aggressive malignancy of bone and soft tissue. It is rare in children under age 5years. Ewing's sarcoma family tumors include classic Ewing’s sarcoma, primitive neuroectodermal tumour and Askin tumor ES is the second most common variety of primary bone cancer in adolescents and young adults. The treatment strategy for ES is characterized by multi-disciplinary collaboration between pediatric oncologists, medical oncologists, radiation oncologists, and orthopedic surgeons. Although the survival rate of ES patients has improved, their prognosis remains unsatisfactory, and the treatment of ES is still challenging specially in age group below 3 years. Patients and methods: A Retrospective study of children below 3 years with a diagnosis Ewing Sarcoma/PNET treated at our CCHE from July 2009 till December 2018. Results: A review of 46 patients with age ranged from 3 months to 3 years, Mean of age was 1.8. Primary site was Osseous and extraosseus in 23 infant patients for each. Main site was mainly axial in 28 cases (60.8%). Cases were treated according to COG protocol. Infantile Ewing sarcoma OS and EFS at 5-years OS were 75.5% and 66.7%. Conclusion: Patients below 3 years represent an unusually young age group. Conclusion: ES/PNET in age below 3 years is a unique age group with a different management and outcome.
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Author Information
  • Department of Clinical Oncology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

  • Orthopedics, Children Cancer Hospital of Egypt, Cairo, Egypt

  • Surgical Oncology, Children Cancer Hospital of Egypt, Cairo, Egypt

  • Surgical Pathology, Children Cancer Hospital of Egypt, Cairo, Egypt

  • Radiotherapy Department, Children Cancer Hospital of Egypt, Cairo, Egypt

  • Radiology Department, Children Cancer Hospital of Egypt, Cairo, Egypt

  • Clinical Research Department, Children Cancer Hospital of Egypt, Cairo, Egypt

  • Department of Clinical Oncology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

  • Pediatric Oncology Department, Children Cancer Hospital of Egypt, Cairo, Egypt

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