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Neuroendocrine Tumours of Gastrointestinal Tract: Our Experience

Received: 10 January 2021     Accepted: 18 January 2021     Published: 24 December 2021
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Abstract

Background: TNE-GEPs are rare and originate in the endocrine system located in the gastrointestinal tract (carcinoids) and in the pancreas (island tumours) with a variety of clinical presentations. Design: Cooperative, retrospective. Method: Between January 2005 and December 2018, a cooperative work in the Central Guard Service of the HNC, General Surgery Service "Pablo Luis Mirizzi" of the HNC and Caraffa Private Clinic, 24 patients with TNE-GEP were surgically intervened. Of the total, 14 belonged to the female sex (58.3%) and the remaining 10 men (41.6%), with an age range between 20 and 82 years of age with an average of 55.3 years. Results: The locations were 4 stomachs (16.6%), 14 in the intestine (58.3%) and finally 6 in the head of the pancreas (25%). In relation to the stomach in the 4 patients a total gastrectomy was performed and the pathological anatomy in three demonstrated low-grade neuroendocrine carcinoma and the fourth high degree, the latter dying. 5 patients with clinical presentations of acute appendicitis. The pathological anatomy was further acute appendicitis, a low-grade neuroendocrine carcinoma. In ileum-cecal region, four of it performed right colectomy. In three were low-grade living and fourth high-grade carcinoma with liver mtts who died. In three of the ileum all were occlusive, carrying out intestinal resections, in two low- and last-grade moderate-grade carcinomas with living liver mtts. The colon tumours were, one ascending with hepatic mtts and right colectomy more liver resections, with pathological anatomy being high-grade carcinoma and another a low-grade descending colon. The 6 pancreas lesions, 3 were non-functioning and three other functioning. All patients were operated of CPD. Conclusion: TNE-GEP is a rare pathology but whose frequency is constant onset. With improved imaging methods, we are faced with an increase in preoperative presumption and in the face of its best oncological possibilities, a pathology that every surgeon must know and think about.

Published in Cancer Research Journal (Volume 9, Issue 4)
DOI 10.11648/j.crj.20210904.13
Page(s) 196-201
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

TNE-GEPs Are Rare, Endocrine System Located in the Gastrointestinal Tract, Surgical Treatment

References
[1] Klöppel G, Rindi G, Anlauf M, et al (2007).: Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors. Virchows Arch. 451: 9-27.
[2] Kourie HR, Ghorra C, Rassy M, et al (2016).: Digestive Neuroendocrine Tumour Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon. Asian. Pac. J. Cancer. Prev. 17 (5): 2679-2681.
[3] Rindi G (2010).: The ENETS guidelines: the new TNM classification system. Tumori. 96: 806-809.
[4] Scoazec JY, Couvelard A (2011).: The new WHO classification if digestive neuroendocrine tumors. Ann Pathol. 31: 88-92.
[5] Kloppel G. (2011): Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms. Endocr. Relat. Cancer. 18: 1-16.
[6] Massironi S, Sciola V, Peracchi M, et al (2008).: Neuroendocrine tumors of the gastro-entero-pancreatic system. World. J. Gastroenterol. 14 (35): 5377-5384.
[7] Williams ED, Sandler M (1963): The classification of carcinoid tumor’s. Lancet. 1: 238-239.
[8] Klimstra DS, Modlin IR, Coppola D, et al (2010).: The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging Systems. Pancreas. 39 (6): 707-712.
[9] Solcia E, Klöppel G, Sobin LH (2000). Histological Typing of Endocrine Tumors. WHO International Histological Classification of Tumors. 2nd ed. Berlin: Springer: 56-70.
[10] Brighi N, La Rosa S, Rossi G, Grillo F Pusceddu S, Rinzivillo M, et al (2020): Morphological Factors Related to Nodal Metastases in Neuroendocrine Tumors of the Appendix: A Multicentric Retrospective Study. Ann. Surg. 271 (3): 527-533.
[11] Mullen JT, Savarese DMF.: Carcinoid tumors of the appendix: a populationbased study. J. Surg. Oncol. 2011. 104: 41–44.
[12] Wu L, Fu J, Wan L, Pan J, Lai S, Zhong J, et al (2017).: Survival outcomes and surgical intervention of small intestinal neuroendocrine tumors: a population based retrospective study. Oncotarget. Vol. 8 (3): 4935-4947.
[13] Bösch F, Bruewer K, D'Anastasi M, Guba M, Werner J, Angele MK, et al (2018).: Neuroendocrine tumours of the small intestine causing a desmoplastic reaction of the mesentery are a more aggressive cohort. Surgery 164 (5): 1093-1099.
[14] Northrop JA, Lee JH (2007).: Large Bowel Carcinoid Tumours. Curr. Opin. Gastroenterol. 23 (1): 74-78.
[15] Calvo Hernán F, Ortiz Bellver v, Berenguer Lapuerta J (2002).: Tumor y síndrome carcinoide. Revis Gastroenterol. 4: 219 – 226.
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  • APA Style

    Paul Eduardo Lada, Casares Gonzalo, Mariot Daniela, Janikow Christian, Saliba Jorge, et al. (2021). Neuroendocrine Tumours of Gastrointestinal Tract: Our Experience. Cancer Research Journal, 9(4), 196-201. https://doi.org/10.11648/j.crj.20210904.13

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    ACS Style

    Paul Eduardo Lada; Casares Gonzalo; Mariot Daniela; Janikow Christian; Saliba Jorge, et al. Neuroendocrine Tumours of Gastrointestinal Tract: Our Experience. Cancer Res. J. 2021, 9(4), 196-201. doi: 10.11648/j.crj.20210904.13

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    AMA Style

    Paul Eduardo Lada, Casares Gonzalo, Mariot Daniela, Janikow Christian, Saliba Jorge, et al. Neuroendocrine Tumours of Gastrointestinal Tract: Our Experience. Cancer Res J. 2021;9(4):196-201. doi: 10.11648/j.crj.20210904.13

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  • @article{10.11648/j.crj.20210904.13,
      author = {Paul Eduardo Lada and Casares Gonzalo and Mariot Daniela and Janikow Christian and Saliba Jorge and Martínez Julián and Santiago Carrizo and Abril Giménez and Francisco Flórez},
      title = {Neuroendocrine Tumours of Gastrointestinal Tract: Our Experience},
      journal = {Cancer Research Journal},
      volume = {9},
      number = {4},
      pages = {196-201},
      doi = {10.11648/j.crj.20210904.13},
      url = {https://doi.org/10.11648/j.crj.20210904.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20210904.13},
      abstract = {Background: TNE-GEPs are rare and originate in the endocrine system located in the gastrointestinal tract (carcinoids) and in the pancreas (island tumours) with a variety of clinical presentations. Design: Cooperative, retrospective. Method: Between January 2005 and December 2018, a cooperative work in the Central Guard Service of the HNC, General Surgery Service "Pablo Luis Mirizzi" of the HNC and Caraffa Private Clinic, 24 patients with TNE-GEP were surgically intervened. Of the total, 14 belonged to the female sex (58.3%) and the remaining 10 men (41.6%), with an age range between 20 and 82 years of age with an average of 55.3 years. Results: The locations were 4 stomachs (16.6%), 14 in the intestine (58.3%) and finally 6 in the head of the pancreas (25%). In relation to the stomach in the 4 patients a total gastrectomy was performed and the pathological anatomy in three demonstrated low-grade neuroendocrine carcinoma and the fourth high degree, the latter dying. 5 patients with clinical presentations of acute appendicitis. The pathological anatomy was further acute appendicitis, a low-grade neuroendocrine carcinoma. In ileum-cecal region, four of it performed right colectomy. In three were low-grade living and fourth high-grade carcinoma with liver mtts who died. In three of the ileum all were occlusive, carrying out intestinal resections, in two low- and last-grade moderate-grade carcinomas with living liver mtts. The colon tumours were, one ascending with hepatic mtts and right colectomy more liver resections, with pathological anatomy being high-grade carcinoma and another a low-grade descending colon. The 6 pancreas lesions, 3 were non-functioning and three other functioning. All patients were operated of CPD. Conclusion: TNE-GEP is a rare pathology but whose frequency is constant onset. With improved imaging methods, we are faced with an increase in preoperative presumption and in the face of its best oncological possibilities, a pathology that every surgeon must know and think about.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Neuroendocrine Tumours of Gastrointestinal Tract: Our Experience
    AU  - Paul Eduardo Lada
    AU  - Casares Gonzalo
    AU  - Mariot Daniela
    AU  - Janikow Christian
    AU  - Saliba Jorge
    AU  - Martínez Julián
    AU  - Santiago Carrizo
    AU  - Abril Giménez
    AU  - Francisco Flórez
    Y1  - 2021/12/24
    PY  - 2021
    N1  - https://doi.org/10.11648/j.crj.20210904.13
    DO  - 10.11648/j.crj.20210904.13
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 196
    EP  - 201
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20210904.13
    AB  - Background: TNE-GEPs are rare and originate in the endocrine system located in the gastrointestinal tract (carcinoids) and in the pancreas (island tumours) with a variety of clinical presentations. Design: Cooperative, retrospective. Method: Between January 2005 and December 2018, a cooperative work in the Central Guard Service of the HNC, General Surgery Service "Pablo Luis Mirizzi" of the HNC and Caraffa Private Clinic, 24 patients with TNE-GEP were surgically intervened. Of the total, 14 belonged to the female sex (58.3%) and the remaining 10 men (41.6%), with an age range between 20 and 82 years of age with an average of 55.3 years. Results: The locations were 4 stomachs (16.6%), 14 in the intestine (58.3%) and finally 6 in the head of the pancreas (25%). In relation to the stomach in the 4 patients a total gastrectomy was performed and the pathological anatomy in three demonstrated low-grade neuroendocrine carcinoma and the fourth high degree, the latter dying. 5 patients with clinical presentations of acute appendicitis. The pathological anatomy was further acute appendicitis, a low-grade neuroendocrine carcinoma. In ileum-cecal region, four of it performed right colectomy. In three were low-grade living and fourth high-grade carcinoma with liver mtts who died. In three of the ileum all were occlusive, carrying out intestinal resections, in two low- and last-grade moderate-grade carcinomas with living liver mtts. The colon tumours were, one ascending with hepatic mtts and right colectomy more liver resections, with pathological anatomy being high-grade carcinoma and another a low-grade descending colon. The 6 pancreas lesions, 3 were non-functioning and three other functioning. All patients were operated of CPD. Conclusion: TNE-GEP is a rare pathology but whose frequency is constant onset. With improved imaging methods, we are faced with an increase in preoperative presumption and in the face of its best oncological possibilities, a pathology that every surgeon must know and think about.
    VL  - 9
    IS  - 4
    ER  - 

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Author Information
  • Servicio de Cirugía General “Pablo Luis Mirizzi” del Hospital Nacional de Clínicas, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

  • Servicio de Guardia Central del Hospital Nacional de Clínicas, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

  • Servicio de Guardia Central del Hospital Nacional de Clínicas, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

  • Servicio de Guardia Central del Hospital Nacional de Clínicas, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

  • Servicio de Guardia Central del Hospital Nacional de Clínicas, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

  • Residente de Cirugía General del Hospital Nacional de Clínicas, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

  • Residente de Cirugía General del Hospital Nacional de Clínicas, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

  • Residente de Cirugía General del Hospital Nacional de Clínicas, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

  • Servicio de Cirugía General, Clínica Privada Caraffa, Córdoba, Argentina

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