Influence of Intrapartum Fever on Pregnancy Outcomes and Its Prevention and Treatment

Cuihong Su; Fang Liu; Yan Zhang; Yuhong Hu; Ping Chen

doi:doi:10.11648/j.sd.20221002.13

| Peer-Reviewed

Influence of Intrapartum Fever on Pregnancy Outcomes and Its Prevention and Treatment

Cuihong Su, Fang Liu, Yan Zhang, Yuhong Hu, Ping Chen

Published in Science Discovery (Volume 10, Issue 2)

Received: 9 April 2022 Accepted: Published: 14 April 2022

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Intra-partum fever usually complicates the delivery process, and its occurrence is often considered synonymous with chorioamnionitis. This inevitably leads to the use of antibiotics for the affected mother. A review of the literature suggests that this approach is not always appropriate. Most cases of intra-partum fever are secondary to non-infectious factors. Both infectious and non-infectious maternal fevers are associated with transient adverse neonatal complications, while maternal fever at delivery is an important risk factor for long-term neonatal developmental outcomes, including encephalopathy, cerebral palsy, and neonatal death. Also prenatal antibiotic exposure increases the risk of developing allergic diseases in children such as asthma and eosinophilic esophagitis. Timing of intrapartum antibiotic administration is very challenging. More research is needed to explore the etiology of intra-partum fever, to discover ways to prevent and control maternal hypothermia, and the proper use of intra-partum antibiotics to reduce unnecessary antibiotic exposure to the fetus. Therefore, the purpose of this study was to review the prenatal and intra-partum factors associated with fever during labor and delivery and to find ways to prevent and treat them to reduce maternal and fetal complications. Effective measures were taken for management to reduce maternal and fetal complications.

Published in	Science Discovery (Volume 10, Issue 2)
DOI	10.11648/j.sd.20221002.13
Page(s)	36-40
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Intrapartum Fever, Pregnancy, Pregnancy Outcome

References

[1]	Burgess A, Katz JE, Moretti M, Lakhi N. Risk Factors for Intrapartum Fever in Term Gestations and Associated Maternal and Neonatal Sequelae. Gynecol Obstet Invest. 2017. 82 (5): 508-516.
[2]	Jensen ET, Kuhl JT, Martin LJ, Rothenberg ME, Dellon ES. Prenatal, intrapartum, and postnatal factors are associated with pediatric eosinophilic esophagitis. J Allergy Clin Immunol. 2018. 141 (1): 214-222.
[3]	Baron R, Taye M, der Vaart IB, et al. The relationship of prenatal antibiotic exposure and infant antibiotic administration with childhood allergies: a systematic review. BMC Pediatr. 2020. 20 (1): 312.
[4]	李欣桐，李彩娟，张媛，沈晓凤。产间发热相关因素的研究进展。医学综述。2021. 27 (17): 3439-3444。
[5]	Gluck O, Mizrachi Y, Ganer Herman H, Bar J, Kovo M, Weiner E. The correlation between the number of vaginal examinations during active labor and febrile morbidity, a retrospective cohort study. BMC Pregnancy Childbirth. 2020. 20 (1): 246.
[6]	Seiler FA, Scavone BM, Shahul S, Arnolds DE. Maternal Fever Associated With Continuous Spinal Versus Epidural Labor Analgesia: A Single-Center Retrospective Study. Anesth Analg. 2022.
[7]	梅洪梁，谢菡，张海霞，葛卫红，戴毅敏。硬膜外分娩镇痛相关产时发热影响因素分析。现代妇产科进展。2022. 31 (02): 81-85。
[8]	肖喜荣，李笑天。妊娠期发热对妊娠结局的影响。中华产科急救电子杂志。2018. 7 (02): 104-107。
[9]	Wass CT, Lanier WL, Hofer RE, Scheithauer BW, Andrews AG. Temperature changes of > or = 1 degree C alter functional neurologic outcome and histopathology in a canine model of complete cerebral ischemia. Anesthesiology. 1995. 83 (2): 325-35.
[10]	Pollock W, Rose L, Dennis CL. Pregnant and postpartum admissions to the intensive care unit: a systematic review. Intensive Care Med. 2010. 36 (9): 1465-74.
[11]	陈晓丹，侯红瑛。羊膜腔感染诊断与治疗。中华产科急救电子杂志。2020. 9 (04): 204-207。
[12]	Committee Opinion No. 712: Intrapartum Management of Intraamniotic Infection. Obstet Gynecol. 2017. 130 (2): e95-e101.
[13]	中华医学会围产医学分会，中华医学会妇产科学分会产科学组。预防围产期B族链球菌病(中国)专家共识。中华围产医学杂志。2021. 24 (08): 561-566。
[14]	林洪丽，谢华，简桂花，何娅妮，陈香美。中国女性尿路感染诊疗专家共识。中华医学杂志。2017. 97 (36): 2827-2832。
[15]	妊娠期应用辐射性影像学检查的专家建议。中华围产医学杂志。2020 (03): 145-146-147-148-149。
[16]	郑建琼，陈海迎，倪菲菲等。产时抗生素预防对B族溶血性链球菌定植产妇新生儿结局影响研究。中国实用妇科与产科杂志。2018. 34 (06): 675-679。
[17]	Gupta S, Forbes-Coe A, Rudd D, Kandasamy Y. Is peripartum maternal fever alone a reliable predictor of neonatal sepsis? A single-centre, retrospective cohort study. J Paediatr Child Health. 2021. 57 (9): 1420-1425.
[18]	Towers CV, Yates A, Zite N, Smith C, Chernicky L, Howard B. Incidence of fever in labor and risk of neonatal sepsis. Am J Obstet Gynecol. 2017. 216 (6): 596.e1-596.e5.
[19]	Oliveira C, Flôr-de-Lima F, Rocha G, Machado AP, Guimarães Pereira Areias M. Meconium aspiration syndrome: risk factors and predictors of severity. J Matern Fetal Neonatal Med. 2019. 32 (9): 1492-1498.
[20]	Ge Y, Zhang C, Cai Y, Huang H. Adverse Maternal and Neonatal Outcomes in Women With Elevated Intrapartum Temperature Complicated by Histological Chorioamnionitis at Term: A Propensity-Score Matched Study. Front Pediatr. 2021. 9: 654596.
[21]	Li C, Miao JK, Xu Y, et al. Prenatal, perinatal and neonatal risk factors for perinatal arterial ischaemic stroke: a systematic review and meta-analysis. Eur J Neurol. 2017. 24 (8): 1006-1015.
[22]	Morton S, Kua J, Mullington CJ. Epidural analgesia, intrapartum hyperthermia, and neonatal brain injury: a systematic review and meta-analysis. Br J Anaesth. 2021. 126 (2): 500-515.
[23]	Sharabi H, Khatib N, Ginsberg Y, et al. Therapeutic N-Acetyl-Cysteine (Nac) Following Initiation of Maternal Inflammation Attenuates Long-Term Offspring Cerebral Injury, as Evident in Magnetic Resonance Imaging (MRI). Neuroscience. 2019. 403: 118-124.
[24]	Buhimschi CS, Bahtiyar MO, Zhao G, et al. Antenatal N-acetylcysteine to improve outcomes of premature infants with intra-amniotic infection and inflammation (Triple I): randomized clinical trial. Pediatr Res. 2021. 89 (1): 175-184.
[25]	Conde-Agudelo A, Romero R, Jung EJ, Garcia SÁJ. Management of clinical chorioamnionitis: an evidence-based approach. Am J Obstet Gynecol. 2020. 223 (6): 848-869.
[26]	Woodd SL, Montoya A, Barreix M, et al. Incidence of maternal peripartum infection: A systematic review and meta-analysis. PLoS Med. 2019. 16 (12): e1002984.

Cite This Article

Plain Text BibTeX RIS

APA Style

Cuihong Su, Fang Liu, Yan Zhang, Yuhong Hu, Ping Chen. (2022). Influence of Intrapartum Fever on Pregnancy Outcomes and Its Prevention and Treatment. Science Discovery, 10(2), 36-40. https://doi.org/10.11648/j.sd.20221002.13

Copy | Download

ACS Style

Cuihong Su; Fang Liu; Yan Zhang; Yuhong Hu; Ping Chen. Influence of Intrapartum Fever on Pregnancy Outcomes and Its Prevention and Treatment. Sci. Discov. 2022, 10(2), 36-40. doi: 10.11648/j.sd.20221002.13

Copy | Download

AMA Style

Cuihong Su, Fang Liu, Yan Zhang, Yuhong Hu, Ping Chen. Influence of Intrapartum Fever on Pregnancy Outcomes and Its Prevention and Treatment. Sci Discov. 2022;10(2):36-40. doi: 10.11648/j.sd.20221002.13

Copy | Download

@article{10.11648/j.sd.20221002.13,
  author = {Cuihong Su and Fang Liu and Yan Zhang and Yuhong Hu and Ping Chen},
  title = {Influence of Intrapartum Fever on Pregnancy Outcomes and Its Prevention and Treatment},
  journal = {Science Discovery},
  volume = {10},
  number = {2},
  pages = {36-40},
  doi = {10.11648/j.sd.20221002.13},
  url = {https://doi.org/10.11648/j.sd.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20221002.13},
  abstract = {Intra-partum fever usually complicates the delivery process, and its occurrence is often considered synonymous with chorioamnionitis. This inevitably leads to the use of antibiotics for the affected mother. A review of the literature suggests that this approach is not always appropriate. Most cases of intra-partum fever are secondary to non-infectious factors. Both infectious and non-infectious maternal fevers are associated with transient adverse neonatal complications, while maternal fever at delivery is an important risk factor for long-term neonatal developmental outcomes, including encephalopathy, cerebral palsy, and neonatal death. Also prenatal antibiotic exposure increases the risk of developing allergic diseases in children such as asthma and eosinophilic esophagitis. Timing of intrapartum antibiotic administration is very challenging. More research is needed to explore the etiology of intra-partum fever, to discover ways to prevent and control maternal hypothermia, and the proper use of intra-partum antibiotics to reduce unnecessary antibiotic exposure to the fetus. Therefore, the purpose of this study was to review the prenatal and intra-partum factors associated with fever during labor and delivery and to find ways to prevent and treat them to reduce maternal and fetal complications. Effective measures were taken for management to reduce maternal and fetal complications.},
 year = {2022}
}

Copy | Download

TY - JOUR
T1 - Influence of Intrapartum Fever on Pregnancy Outcomes and Its Prevention and Treatment
AU - Cuihong Su
AU - Fang Liu
AU - Yan Zhang
AU - Yuhong Hu
AU - Ping Chen
Y1 - 2022/04/14
PY - 2022
N1 - https://doi.org/10.11648/j.sd.20221002.13
DO - 10.11648/j.sd.20221002.13
T2 - Science Discovery
JF - Science Discovery
JO - Science Discovery
SP - 36
EP - 40
PB - Science Publishing Group
SN - 2331-0650
UR - https://doi.org/10.11648/j.sd.20221002.13
AB - Intra-partum fever usually complicates the delivery process, and its occurrence is often considered synonymous with chorioamnionitis. This inevitably leads to the use of antibiotics for the affected mother. A review of the literature suggests that this approach is not always appropriate. Most cases of intra-partum fever are secondary to non-infectious factors. Both infectious and non-infectious maternal fevers are associated with transient adverse neonatal complications, while maternal fever at delivery is an important risk factor for long-term neonatal developmental outcomes, including encephalopathy, cerebral palsy, and neonatal death. Also prenatal antibiotic exposure increases the risk of developing allergic diseases in children such as asthma and eosinophilic esophagitis. Timing of intrapartum antibiotic administration is very challenging. More research is needed to explore the etiology of intra-partum fever, to discover ways to prevent and control maternal hypothermia, and the proper use of intra-partum antibiotics to reduce unnecessary antibiotic exposure to the fetus. Therefore, the purpose of this study was to review the prenatal and intra-partum factors associated with fever during labor and delivery and to find ways to prevent and treat them to reduce maternal and fetal complications. Effective measures were taken for management to reduce maternal and fetal complications.
VL - 10
IS - 2
ER -

Copy | Download

Author Information

Cuihong Su

Department of Obstetrics and Gynecology, First Affiliated Hospital of Jiamusi University, Jiamusi, China
Fang Liu

Department of Obstetrics and Gynecology, Central Hospital of Tangyuan County, Jiamusi, China
Yan Zhang

Department of Obstetrics and Gynecology, First Affiliated Hospital of Jiamusi University, Jiamusi, China
Yuhong Hu

Department of Obstetrics and Gynecology, First Affiliated Hospital of Jiamusi University, Jiamusi, China
Ping Chen

Department of Obstetrics and Gynecology, First Affiliated Hospital of Jiamusi University, Jiamusi, China

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Cuihong Su, Fang Liu, Yan Zhang, Yuhong Hu, Ping Chen. (2022). Influence of Intrapartum Fever on Pregnancy Outcomes and Its Prevention and Treatment. Science Discovery, 10(2), 36-40. https://doi.org/10.11648/j.sd.20221002.13

Copy | Download

ACS Style

Cuihong Su; Fang Liu; Yan Zhang; Yuhong Hu; Ping Chen. Influence of Intrapartum Fever on Pregnancy Outcomes and Its Prevention and Treatment. Sci. Discov. 2022, 10(2), 36-40. doi: 10.11648/j.sd.20221002.13

Copy | Download

AMA Style

Cuihong Su, Fang Liu, Yan Zhang, Yuhong Hu, Ping Chen. Influence of Intrapartum Fever on Pregnancy Outcomes and Its Prevention and Treatment. Sci Discov. 2022;10(2):36-40. doi: 10.11648/j.sd.20221002.13

Copy | Download

@article{10.11648/j.sd.20221002.13,
  author = {Cuihong Su and Fang Liu and Yan Zhang and Yuhong Hu and Ping Chen},
  title = {Influence of Intrapartum Fever on Pregnancy Outcomes and Its Prevention and Treatment},
  journal = {Science Discovery},
  volume = {10},
  number = {2},
  pages = {36-40},
  doi = {10.11648/j.sd.20221002.13},
  url = {https://doi.org/10.11648/j.sd.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20221002.13},
  abstract = {Intra-partum fever usually complicates the delivery process, and its occurrence is often considered synonymous with chorioamnionitis. This inevitably leads to the use of antibiotics for the affected mother. A review of the literature suggests that this approach is not always appropriate. Most cases of intra-partum fever are secondary to non-infectious factors. Both infectious and non-infectious maternal fevers are associated with transient adverse neonatal complications, while maternal fever at delivery is an important risk factor for long-term neonatal developmental outcomes, including encephalopathy, cerebral palsy, and neonatal death. Also prenatal antibiotic exposure increases the risk of developing allergic diseases in children such as asthma and eosinophilic esophagitis. Timing of intrapartum antibiotic administration is very challenging. More research is needed to explore the etiology of intra-partum fever, to discover ways to prevent and control maternal hypothermia, and the proper use of intra-partum antibiotics to reduce unnecessary antibiotic exposure to the fetus. Therefore, the purpose of this study was to review the prenatal and intra-partum factors associated with fever during labor and delivery and to find ways to prevent and treat them to reduce maternal and fetal complications. Effective measures were taken for management to reduce maternal and fetal complications.},
 year = {2022}
}

Copy | Download