Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure

Boyong Qiu; Wang Zheng; Suyun Yuan; Lin Shen; Duan Zhou; Shaofeng Wang; Yihong Wei

doi:doi:10.11648/j.sjph.20221002.13

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Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure

Boyong Qiu, Wang Zheng, Suyun Yuan, Lin Shen, Duan Zhou, Shaofeng Wang, Yihong Wei

Published in Science Journal of Public Health (Volume 10, Issue 2)

Received: 9 April 2022 Accepted: Published: 14 April 2022

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Abstract

Heart failure (HF) is a worldwide health issue, and the application of Chinese medicine could provide new methods for the treatment of HF. Currently, there is no good medicine for diastolic heart failure (DHF) at present; therefore, we hope our study can confirm the effectiveness of Shen'ge formula (SGF) in the treatment of DHF and provide new strategies for patients with HF. To analyze the potential effect of SGF against HF, especially against DHF, we consult and summarize our previous researches on SGF. Our previous clinical studies demonstrated that SGF combined with conventional western medicine was able to improve ventricular contractility, heart function and reduce serum brain natriuretic peptide (BNP)/NT-proBNP levels of patients. The quality of life and clinical symptoms in HF patients were significantly improved after intervention. And basic researches also manifested that SGF was capable of preserving heart function, improving symptoms, and reducing cardiac hypertrophy and fibrosis in rats. Mechanisms involved in SGF ameliorating heart function probably were through downregulating AT1R, NADPH oxidase 2, 4, inhibiting TGF-β/smads pathway and RhoA/ROCK1 pathway. And SGF reducing serum metabolites accumulation was feasibly by up-regulating heart mRNA expressions of COX2, ATP6 and ATP8. In all, SGF exhibits many advantages in HF treatment according to the results of our previous researches, which indicates that SGF could be the potential beneficial strategy in DHF.

Published in	Science Journal of Public Health (Volume 10, Issue 2)
DOI	10.11648/j.sjph.20221002.13
Page(s)	87-91
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Heart Function, Heart Failure, Shen'ge Formula, Traditional Chinese Medicine

References

[1]	ROGER V L. Epidemiology of heart failure [J]. Circ Res, 2013, 113 (6): 646-59.
[2]	MOSTERD A, HOES A W. Clinical epidemiology of heart failure [J]. Heart, 2007, 93 (9): 1137-46.
[3]	HAO G, WANG X, CHEN Z, et al. Prevalence of heart failure and left ventricular dysfunction in China: the China Hypertension Survey, 2012-2015 [J]. Eur J Heart Fail, 2019, 21 (11): 1329-1337.
[4]	ZHANG Y, ZHANG J, BUTLER J, et al. Contemporary Epidemiology, Management, and Outcomes of Patients Hospitalized for Heart Failure in China: Results From the China Heart Failure (China-HF) Registry [J]. J Card Fail, 2017, 23 (12): 868-875.
[5]	PONIKOWSKI P, VOORS A A, ANKER S D, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure [J]. European Heart Journal, 2016, 37 (27): 2129-U130.
[6]	SIMPSON J, JHUND P S, SILVA CARDOSO J, et al. Comparing LCZ696 with enalapril according to baseline risk using the MAGGIC and EMPHASIS-HF risk scores: an analysis of mortality and morbidity in PARADIGM-HF [J]. J Am Coll Cardiol, 2015, 66 (19): 2059-2071.
[7]	SOLOMON S D, MCMURRAY J J V, ANAND I S, et al. Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction [J]. N Engl J Med, 2019, 381 (17): 1609-1620.
[8]	QI H, REN J, BA L, et al. MSTN Attenuates Cardiac Hypertrophy through Inhibition of Excessive Cardiac Autophagy by Blocking AMPK /mTOR and miR-128/PPARγ/NF-κB [J]. Mol Ther Nucleic Acids, 2020, 19: 507-522.
[9]	WANG W, MENG X, WANG J, et al. Improved heart failure by Rhein lysinate is associated with p38MAPK pathway [J]. Exp Ther Med, 2018, 16 (3): 2046-2051.
[10]	LUO M, CHEN P P, YANG L, et al. Sodium ferulate inhibits myocardial hypertrophy induced by abdominal coarctation in rats: Involvement of cardiac PKC and MAPK signaling pathways [J]. Biomed Pharmacother, 2019, 112: 108735.
[11]	TANG F, LU M, YU L, et al. Inhibition of TNF-α-mediated NF-κB Activation by Ginsenoside Rg1 Contributes the Attenuation of Cardiac Hypertrophy Induced by Abdominal Aorta Coarctation [J]. J Cardiovasc Pharmacol, 2016, 68 (4): 257-264.
[12]	WEI Y H, WU S, CAO M, et al. Effects of Shenge Powder on the Hemodynamics and the Expression of RhoA and Rock1 in Rats with Pressure-overload Heart Failure [J]. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease, 2014, 12 (01): 65-67.
[13]	WEI Y H, WU S, CAO M, et al. Impacts of Shenge Powder on Heart Function and Myocardial Hypertrophy in the Rats of Pressure Overload-Induced Chronic Heart Failure [J]. World Journal of Integrated Traditional and Western Medicine, 2013, 8 (12): 1271-1273+1277.
[14]	ZHU L Y, WEI Y H, YANG J, et al. Effect of Shen'ge formula on cardiac function in heart failure rats with abdominal aortic constriction [J]. Proprietary Chinese medicine, 2017, 39 (09): 1766-1770.
[15]	WU S, WEI Y H, CAO M, et al. Effect of Shen′ge Powder on the Heart Function of Rats with Pressure-overload Induced Heart Failure [J]. Journal of Emergency in Traditional Chinese Medicine, 2013, 22 (10): 1655-1657.
[16]	ROGERS C, BUSH N. Heart Failure: Pathophysiology, Diagnosis, Medical Treatment Guidelines, and Nursing Management [J]. Nurs Clin North Am, 2015, 50 (4): 787-99.
[17]	NAKAMURA M, SADOSHIMA J. Mechanisms of physiological and pathological cardiac hypertrophy [J]. Nat Rev Cardiol, 2018, 15 (7): 387-407.
[18]	KAPLINSKY E. Significance of left ventricular hypertrophy in cardiovascular morbidity and mortality [J]. Cardiovasc Drugs Ther, 1994, 8 Suppl 3: 549-56.
[19]	TANAI E, FRANTZ S. Pathophysiology of Heart Failure [J]. Compr Physiol, 2015, 6 (1): 187-214.
[20]	SABBAH H N, SHAROV V G, LESCH M, et al. Progression of heart failure: a role for interstitial fibrosis [J]. Mol Cell Biochem, 1995, 147 (1-2): 29-34.
[21]	MAGGIONI A P, DAHLSTRöM U, FILIPPATOS G, et al. EURObservational Research Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot) [J]. Eur J Heart Fail, 2013, 15 (7): 808-17.
[22]	ZAKERI R, MORGAN J M, PHILLIPS P, et al. Prevalence and prognostic significance of device-detected subclinical atrial fibrillation in patients with heart failure and reduced ejection fraction [J]. Int J Cardiol, 2020, 312: 64-70.
[23]	ZHOU L, ZHOU D, CAO M. Effect of Shen'ge formula on myocardial AT1R in rats with pressure load ventricular remodeling [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2014, 41 (05): 1042-1043.
[24]	LIANG Y Q, ZHOU L, ZHOU D, et al. Effect of Shen'ge Powder on TGF-β1/Smads signal transduction in ventricular remodeling rats [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2014, 41 (10): 2232-2236.
[25]	WEI Y H, WU S, CAO M, et al. Effect of Shen'ge Powder on Expressions of NADPH Oxidase 2, 4 in Cardiomyocyte in Pressure-Overload Heart Failure Rats [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2014, 16 (04): 14-17.
[26]	ZHU L Y, WEI Y H, ZHAO W Q, et al. Effects of Shen'ge Powder on heart function in rats with heart failure by mitochondrial of abdominal aorta [J]. Chinese Traditional Patent Medicine, 2017, 58 (08): 678-681.
[27]	ZHANG W Z, ZHANG Y Y, ZHOU D, et al. Clinical observation of ‘Ginseng-Gecko Powder’ in treating congestive heart failure [J]. Shanghai Journal of Traditional Chinese Medicine, 2010, 44 (06): 59-61.
[28]	QIAO S Y, LI G H, DING L W, et al. Clinical Observation on the Adjunctive Therapy with Shenge Powder Treating 36 Cases of Chronic Heart Failure of Heart and Kidney Yang Deficiency Syndrome [J]. Journal of traditional Chinese medicine, 2020, 61 (17): 1536-1540.
[29]	QIU B, ZHAO P, SHEN L, et al. Improvement of Shen'ge formula on heart function in diastolic heart failure: A protocol for randomized, double-blind, placebo-controlled clinical study [J]. Medicine (Baltimore), 2021, 100 (13): e25383.
[30]	BAI H Y, LI Y F, HAN K, et al. Effectiveness of Chinese Herbal Medicine as an Adjunctive Treatment for Dilated Cardiomyopathy in Patients with Heart Failure [J]. Journal of Alternative and Complementary Medicine, 2013, 19 (10): 811-819.
[31]	LI Y L, JU J Q, YANG C H, et al. Oral Chinese herbal medicine for improvement of quality of life in patients with chronic heart failure: a systematic review and meta-analysis [J]. Quality of Life Research, 2014, 23 (4): 1177-1192.

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APA Style

Boyong Qiu, Wang Zheng, Suyun Yuan, Lin Shen, Duan Zhou, et al. (2022). Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure. Science Journal of Public Health, 10(2), 87-91. https://doi.org/10.11648/j.sjph.20221002.13

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ACS Style

Boyong Qiu; Wang Zheng; Suyun Yuan; Lin Shen; Duan Zhou, et al. Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure. Sci. J. Public Health 2022, 10(2), 87-91. doi: 10.11648/j.sjph.20221002.13

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AMA Style

Boyong Qiu, Wang Zheng, Suyun Yuan, Lin Shen, Duan Zhou, et al. Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure. Sci J Public Health. 2022;10(2):87-91. doi: 10.11648/j.sjph.20221002.13

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@article{10.11648/j.sjph.20221002.13,
  author = {Boyong Qiu and Wang Zheng and Suyun Yuan and Lin Shen and Duan Zhou and Shaofeng Wang and Yihong Wei},
  title = {Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure},
  journal = {Science Journal of Public Health},
  volume = {10},
  number = {2},
  pages = {87-91},
  doi = {10.11648/j.sjph.20221002.13},
  url = {https://doi.org/10.11648/j.sjph.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20221002.13},
  abstract = {Heart failure (HF) is a worldwide health issue, and the application of Chinese medicine could provide new methods for the treatment of HF. Currently, there is no good medicine for diastolic heart failure (DHF) at present; therefore, we hope our study can confirm the effectiveness of Shen'ge formula (SGF) in the treatment of DHF and provide new strategies for patients with HF. To analyze the potential effect of SGF against HF, especially against DHF, we consult and summarize our previous researches on SGF. Our previous clinical studies demonstrated that SGF combined with conventional western medicine was able to improve ventricular contractility, heart function and reduce serum brain natriuretic peptide (BNP)/NT-proBNP levels of patients. The quality of life and clinical symptoms in HF patients were significantly improved after intervention. And basic researches also manifested that SGF was capable of preserving heart function, improving symptoms, and reducing cardiac hypertrophy and fibrosis in rats. Mechanisms involved in SGF ameliorating heart function probably were through downregulating AT1R, NADPH oxidase 2, 4, inhibiting TGF-β/smads pathway and RhoA/ROCK1 pathway. And SGF reducing serum metabolites accumulation was feasibly by up-regulating heart mRNA expressions of COX2, ATP6 and ATP8. In all, SGF exhibits many advantages in HF treatment according to the results of our previous researches, which indicates that SGF could be the potential beneficial strategy in DHF.},
 year = {2022}
}

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TY  - JOUR
T1  - Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure
AU  - Boyong Qiu
AU  - Wang Zheng
AU  - Suyun Yuan
AU  - Lin Shen
AU  - Duan Zhou
AU  - Shaofeng Wang
AU  - Yihong Wei
Y1  - 2022/04/14
PY  - 2022
N1  - https://doi.org/10.11648/j.sjph.20221002.13
DO  - 10.11648/j.sjph.20221002.13
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 87
EP  - 91
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20221002.13
AB  - Heart failure (HF) is a worldwide health issue, and the application of Chinese medicine could provide new methods for the treatment of HF. Currently, there is no good medicine for diastolic heart failure (DHF) at present; therefore, we hope our study can confirm the effectiveness of Shen'ge formula (SGF) in the treatment of DHF and provide new strategies for patients with HF. To analyze the potential effect of SGF against HF, especially against DHF, we consult and summarize our previous researches on SGF. Our previous clinical studies demonstrated that SGF combined with conventional western medicine was able to improve ventricular contractility, heart function and reduce serum brain natriuretic peptide (BNP)/NT-proBNP levels of patients. The quality of life and clinical symptoms in HF patients were significantly improved after intervention. And basic researches also manifested that SGF was capable of preserving heart function, improving symptoms, and reducing cardiac hypertrophy and fibrosis in rats. Mechanisms involved in SGF ameliorating heart function probably were through downregulating AT1R, NADPH oxidase 2, 4, inhibiting TGF-β/smads pathway and RhoA/ROCK1 pathway. And SGF reducing serum metabolites accumulation was feasibly by up-regulating heart mRNA expressions of COX2, ATP6 and ATP8. In all, SGF exhibits many advantages in HF treatment according to the results of our previous researches, which indicates that SGF could be the potential beneficial strategy in DHF.
VL  - 10
IS  - 2
ER  -

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Author Information

Boyong Qiu

The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China
Wang Zheng

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Suyun Yuan

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Lin Shen

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Duan Zhou

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Shaofeng Wang

Chuansha Huaxia Community Health Service Center, Shanghai, China
Yihong Wei

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

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Plain Text BibTeX RIS

APA Style

Boyong Qiu, Wang Zheng, Suyun Yuan, Lin Shen, Duan Zhou, et al. (2022). Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure. Science Journal of Public Health, 10(2), 87-91. https://doi.org/10.11648/j.sjph.20221002.13

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ACS Style

Boyong Qiu; Wang Zheng; Suyun Yuan; Lin Shen; Duan Zhou, et al. Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure. Sci. J. Public Health 2022, 10(2), 87-91. doi: 10.11648/j.sjph.20221002.13

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AMA Style

Boyong Qiu, Wang Zheng, Suyun Yuan, Lin Shen, Duan Zhou, et al. Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure. Sci J Public Health. 2022;10(2):87-91. doi: 10.11648/j.sjph.20221002.13

Copy | Download

@article{10.11648/j.sjph.20221002.13,
  author = {Boyong Qiu and Wang Zheng and Suyun Yuan and Lin Shen and Duan Zhou and Shaofeng Wang and Yihong Wei},
  title = {Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure},
  journal = {Science Journal of Public Health},
  volume = {10},
  number = {2},
  pages = {87-91},
  doi = {10.11648/j.sjph.20221002.13},
  url = {https://doi.org/10.11648/j.sjph.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20221002.13},
  abstract = {Heart failure (HF) is a worldwide health issue, and the application of Chinese medicine could provide new methods for the treatment of HF. Currently, there is no good medicine for diastolic heart failure (DHF) at present; therefore, we hope our study can confirm the effectiveness of Shen'ge formula (SGF) in the treatment of DHF and provide new strategies for patients with HF. To analyze the potential effect of SGF against HF, especially against DHF, we consult and summarize our previous researches on SGF. Our previous clinical studies demonstrated that SGF combined with conventional western medicine was able to improve ventricular contractility, heart function and reduce serum brain natriuretic peptide (BNP)/NT-proBNP levels of patients. The quality of life and clinical symptoms in HF patients were significantly improved after intervention. And basic researches also manifested that SGF was capable of preserving heart function, improving symptoms, and reducing cardiac hypertrophy and fibrosis in rats. Mechanisms involved in SGF ameliorating heart function probably were through downregulating AT1R, NADPH oxidase 2, 4, inhibiting TGF-β/smads pathway and RhoA/ROCK1 pathway. And SGF reducing serum metabolites accumulation was feasibly by up-regulating heart mRNA expressions of COX2, ATP6 and ATP8. In all, SGF exhibits many advantages in HF treatment according to the results of our previous researches, which indicates that SGF could be the potential beneficial strategy in DHF.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Shen'ge Formula Could Protect Heart Function: A Traditional Chinese Medicine Method for Heart Failure
AU  - Boyong Qiu
AU  - Wang Zheng
AU  - Suyun Yuan
AU  - Lin Shen
AU  - Duan Zhou
AU  - Shaofeng Wang
AU  - Yihong Wei
Y1  - 2022/04/14
PY  - 2022
N1  - https://doi.org/10.11648/j.sjph.20221002.13
DO  - 10.11648/j.sjph.20221002.13
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 87
EP  - 91
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20221002.13
AB  - Heart failure (HF) is a worldwide health issue, and the application of Chinese medicine could provide new methods for the treatment of HF. Currently, there is no good medicine for diastolic heart failure (DHF) at present; therefore, we hope our study can confirm the effectiveness of Shen'ge formula (SGF) in the treatment of DHF and provide new strategies for patients with HF. To analyze the potential effect of SGF against HF, especially against DHF, we consult and summarize our previous researches on SGF. Our previous clinical studies demonstrated that SGF combined with conventional western medicine was able to improve ventricular contractility, heart function and reduce serum brain natriuretic peptide (BNP)/NT-proBNP levels of patients. The quality of life and clinical symptoms in HF patients were significantly improved after intervention. And basic researches also manifested that SGF was capable of preserving heart function, improving symptoms, and reducing cardiac hypertrophy and fibrosis in rats. Mechanisms involved in SGF ameliorating heart function probably were through downregulating AT1R, NADPH oxidase 2, 4, inhibiting TGF-β/smads pathway and RhoA/ROCK1 pathway. And SGF reducing serum metabolites accumulation was feasibly by up-regulating heart mRNA expressions of COX2, ATP6 and ATP8. In all, SGF exhibits many advantages in HF treatment according to the results of our previous researches, which indicates that SGF could be the potential beneficial strategy in DHF.
VL  - 10
IS  - 2
ER  -

Copy | Download