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Division of Nutrition and Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan
For postprandial hyperlipidemia, screening large numbers of subjects by fat-ingestion tests is inconvenient and unrealistic. In the present study, we performed a fat-ingestion test and searched for fasting items to predict postprandial lipidemia. Methods: Healthy young Japanese women (n=54, age 21.1 ± 1.0 y) with apolipoprotein E phenotype 3/3 were enrolled. They ingested fat cream (OFTT cream™, Jomo, Japan; 1 g/kg as cream, 0.35 g/kg as fat). Venous blood samples were taken before (0 h) and at 0.5, 1, 2, 4, and 6 h after ingestion. Results: In multiple regression analyses, the area under the curve (AUC) and the peak of serum triglyceride (TG) were predictable by fasting (f)-TG itself, the AUC of remnant-like particle-TG (RP-TG) was predictable by f-TG and f-RP-TG, the AUC and the peak of remnant lipoprotein-cholesterol (RLP-C) were predictable by f-RLP-C itself, and those of apolipoprotein B-48 (ApoB48) were predictable by f-ApoB48 itself. The AUC and the peak of TG–RP-TG, an index of non-remnant TG, were predictable by f-TG. Conclusion: Postprandial lipidemia may be predictable by the measurement of the set of fasting serum TG, RLP-C, and ApoB48. For daily medical practice, without performing a fat-ingestion test, the set may provide a useful device for predicting postprandial lipidemia.
Predictability, Fat-Ingestion Test, Postprandial Lipidemia, Triglyceride, Remnant Lipoprotein-Cholesterol, Apolipoprotein B-48, Women
Erika Mizutani-Watanabe, Michitaka Naito. (2023). Predictability of Postprandial Lipidemia by Fasting Values in Young Women. International Journal of Nutrition and Food Sciences, 12(5), 116-122. https://doi.org/10.11648/j.ijnfs.20231205.11
Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
1. | Zilversmit DB: Atherogenesis: a postprandial phenomenon. Circulation 1979; 60: 473–485. |
2. | Takeuchi K, Kazumura K, Kuzawa K, Hatano Y, Nagai M, Naito M: Effect of fat ingestion on postprandial oxidative status in healthy young women: a pilot study. Journal of Clinical Biochemistry and Nutrition 2023 https://doi.org/10.3164/jcbn.23-50. (Advance online publication) |
3. | Nabeno Y, Fukuchi Y, Matsutani Y, Naito M: Influence of aging and menopause on postprandial lipoprotein responses in healthy adult women. Journal of Atherosclerosis and Thrombosis 2007; 14: 142–150. |
4. | Mizutani-Watanabe E, Naito M: Remnant indices for estimating postprandial lipidemia in young women. International Journal of Nutrition and Food Sciences 2023; 12: 21–28. |
5. | Asano M, Fukakura N, Adachi J, Kawaraya C, Nanba A, Yasuda N, Yamamoto E: Use of fast foods among young people. Japanese Journal of Nutrition and Diet 2003; 61: 47–54. (In Japanese). |
6. | Ichikawa N, Morita Y, Ootani K, Naito M: Effects of co-ingestion of amino acids with fat on postchallenge glycemia and lipidemia in healthy young women. International Journal of Nutrition and Food Sciences 2022; 11: 177–186. |
7. | Matthews DR, Hosker JR, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and β -cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412–419. |
8. | Friedewald W, Levy R, Fredrickson D: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry 1972; 18: 499–502. |
9. | Nakajima K, Saito T, Tamura A, Suzuki M, Nakano T, Adachi M, Tanaka A, Tada N, Nakamura H, Campos E, Havel RJ: Cholesterol in remnant-like lipoproteins in human serum using monoclonal anti apo B-100 and anti apo A-I immunoaffinity mixed gels. Clinica Chimica Acta 1993; 223: 53–71. |
10. | Miyauchi K, Kayahara N, Ishigami M, Kuwata H, Mori H, Sugiuchi H, Irie T, Tanaka A, Yamashita S, Yamamura T: Development of a homogeneous assay to measure remnant lipoprotein cholesterol. Clinical Chemistry 2007; 53: 2128–2135. |
11. | Nakatani K, Sugimoto T, Masuda D, Okano R, Oya T, Monden Y, Yamashita T, Kawase R, Nakaoka H, Inagaki M, Yuasa-Kawase M, Tsubakio-Yamamoto K, Ohama T, Nishida M, Ishigami M, Komuro I, Yamashita S: Serum apolipoprotein B-48 levels are correlated with carotid intima-media thickness in subjects with normal serum triglyceride levels. Atherosclerosis 2011; 218: 226–232. |
12. | The National Health and Nutrition Survey in Japan, 2019 https://www.mhlw.go.jp/content/001066903.pdf. (In Japanese) (Accessed on July 1, 2023). |
13. | Couillard C, Bergeron N, Prud’homme D, Bergeron J, Tremblay A, Bouchard C, Mauriège P, Després JP: Postprandial triglyceride response in visceral obesity in men. Diabetes 1998; 47: 953–960. |
14. | Wideman L, Kaminsky LA, Whaley MH: Postprandial lipemia in obese men with abdominal fat patterning. Journal of Sports Medicine and Physical Fitness 1996; 36: 204–210. |
15. | Blackburn P, Lamarche B, Couillard C, Pascot A, Bergeron N, Prud’homme D, Tremblay A, Bergeron J, Lemieux I, Després JP: Postprandial hyperlipidemia: another correlate of the “hypertriglyceridemic waist” phenotype in men. Atherosclerosis 2003; 171: 327–336. |
16. | Bansal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM: Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. Journal of the American Medical Association 2007; 298: 309–316. |
17. | Kolovou GD, Watts GF, Mikhailidis DP, Perez-Martinez P, Mora S, Bilianou H, Panotopoulos G, Katsiki N, Ooi TC, Lopez-Miranda J, Tybjærg-Hansen A, Tentolouris N, Nordestgaard BG: Postprandial hypertriglyceridaemia revisited in the era of non-fasting lipid profile testing: a 2019 expert panel statement, main text. Current Vascular Pharmacology 2019; 17: 498–514. |
18. | Klempfner R, Erez A, Sagit BZ, Goldenberg I, Fisman E, Kopel E; Shlomo N, Israel A, Tenenbaum A: Elevated triglyceride level is independently associated with increased all-cause mortality in patients with established coronary heart disease: twenty-two-year follow-up of the Bezafibrate Infarction Prevention Study and Registry. Circulation-Cardiovascular Quality and Outcomes 2016; 9: 100–108. |