Meta-analysis of Risk Factors for Mortality in Patients with Acinetobacter Baumannii Bloodstream Infection

Xu Han; Haiyan Huang; Weitao Lv; Wanxian Lu

doi:doi:10.11648/j.ajns.20211001.22

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Meta-analysis of Risk Factors for Mortality in Patients with Acinetobacter Baumannii Bloodstream Infection

Xu Han, Haiyan Huang, Weitao Lv, Wanxian Lu

Published in American Journal of Nursing Science (Volume 10, Issue 1)

Received: 7 February 2021 Accepted: 17 February 2021 Published: 23 February 2021

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Abstract

Background: Patients with Acinetobacter baumannii bloodstream infection (ABBI) have a poor prognosis and high mortality. Early identification of risk factors for death in patients with ABBI, and appropriate prevention and control measures are extremely important to reduce the mortality. Objective: To systematically evaluate the risk factors of ABBI, which provide evidence for reducing the incidence and mortality of patients. Methods: The published articles and reference works on prognosis risk factors in patients with ABBI were retrieved from inception to January 2021 in the following databases: PubMed, Web of Science, Embase, CNKI, Wanfang and VIP. Those studies that met the inclusion criteria were perform quality evaluation and data analysis. Meta-analysis was performed by the statistical software Stata13.0. Results: A total of 24 articles were included, including 1 203 patients in the death group and 1 319 patients in the survival group. Among the 24 included study factors, 15 showed statistically significant differences(P<0.01), including: age (MD=0.19, 95%CI: 0.08~0.30, P<0.01), APACHE II (MD=0.48, 95%CI: 0.06~0.91, P=0.03), ICU admission (OR=1.91, 95%CI: 1.12~3.26, P=0.02), shock (OR=4.28, 95% CI: 1.05~17.49, P=0.04), septic shock (OR=8.36, 95%CI: 3.71~18.82, P<0.01), renal damage (OR=1.57, 95%CI: 1.19~2.07, P<0.01), diabetes (OR=1.31,95%CI: 1.03~1.68, P=0.03), malignant tumor (OR=1.56, 95%CI: 1.02~2.37, P=0.04 ), liver disease (OR=1.93, 95%CI: 1.25~3.00, P<0.01), hormonal used (OR=5.46, 95%CI: 3.12~9.56, P<0.01), immunosuppression (OR=2.73, 95%CI: 1.82~4.1, P<0.01 ), mechanical ventilation (OR=3.17, 95%CI: 2.34~4.29, P<0.01), deep vein catheterization (OR=2.02, 95%CI: 1.56~2.61, P<0.01), indwelling urinary catheter (OR =2.53, 95%CI: 1.66~3.84, P<0.01), indwelling gastric tube (OR=1.79, 95%CI: 1.21~2.65, P<0.01). Conclusion: The severity of the patient's underlying disease, using of hormones and immunosuppressants, and various invasive operations were the main risk factors for high mortality in ABBI patients. It was necessary to focus on older patients, dynamically monitor the APACHE II score, carefully evaluate the effect of hormone and immunosuppressant application, and strictly control the indications of invasive operation or treatment.

Published in	American Journal of Nursing Science (Volume 10, Issue 1)
DOI	10.11648/j.ajns.20211001.22
Page(s)	64-70
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Acinetobacter Baumannii, Bloodstream Infection, Risk Factors, Mortality, Meta-analysis

References

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APA Style

Xu Han, Haiyan Huang, Weitao Lv, Wanxian Lu. (2021). Meta-analysis of Risk Factors for Mortality in Patients with Acinetobacter Baumannii Bloodstream Infection. American Journal of Nursing Science, 10(1), 64-70. https://doi.org/10.11648/j.ajns.20211001.22

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ACS Style

Xu Han; Haiyan Huang; Weitao Lv; Wanxian Lu. Meta-analysis of Risk Factors for Mortality in Patients with Acinetobacter Baumannii Bloodstream Infection. Am. J. Nurs. Sci. 2021, 10(1), 64-70. doi: 10.11648/j.ajns.20211001.22

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AMA Style

Xu Han, Haiyan Huang, Weitao Lv, Wanxian Lu. Meta-analysis of Risk Factors for Mortality in Patients with Acinetobacter Baumannii Bloodstream Infection. Am J Nurs Sci. 2021;10(1):64-70. doi: 10.11648/j.ajns.20211001.22

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@article{10.11648/j.ajns.20211001.22,
  author = {Xu Han and Haiyan Huang and Weitao Lv and Wanxian Lu},
  title = {Meta-analysis of Risk Factors for Mortality in Patients with Acinetobacter Baumannii Bloodstream Infection},
  journal = {American Journal of Nursing Science},
  volume = {10},
  number = {1},
  pages = {64-70},
  doi = {10.11648/j.ajns.20211001.22},
  url = {https://doi.org/10.11648/j.ajns.20211001.22},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajns.20211001.22},
  abstract = {Background: Patients with Acinetobacter baumannii bloodstream infection (ABBI) have a poor prognosis and high mortality. Early identification of risk factors for death in patients with ABBI, and appropriate prevention and control measures are extremely important to reduce the mortality. Objective: To systematically evaluate the risk factors of ABBI, which provide evidence for reducing the incidence and mortality of patients. Methods: The published articles and reference works on prognosis risk factors in patients with ABBI were retrieved from inception to January 2021 in the following databases: PubMed, Web of Science, Embase, CNKI, Wanfang and VIP. Those studies that met the inclusion criteria were perform quality evaluation and data analysis. Meta-analysis was performed by the statistical software Stata13.0. Results: A total of 24 articles were included, including 1 203 patients in the death group and 1 319 patients in the survival group. Among the 24 included study factors, 15 showed statistically significant differences(PPP=0.03), ICU admission (OR=1.91, 95%CI: 1.12~3.26, P=0.02), shock (OR=4.28, 95% CI: 1.05~17.49, P=0.04), septic shock (OR=8.36, 95%CI: 3.71~18.82, PPP=0.03), malignant tumor (OR=1.56, 95%CI: 1.02~2.37, P=0.04 ), liver disease (OR=1.93, 95%CI: 1.25~3.00, PPPPPPP<0.01). Conclusion: The severity of the patient's underlying disease, using of hormones and immunosuppressants, and various invasive operations were the main risk factors for high mortality in ABBI patients. It was necessary to focus on older patients, dynamically monitor the APACHE II score, carefully evaluate the effect of hormone and immunosuppressant application, and strictly control the indications of invasive operation or treatment.},
 year = {2021}
}

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TY  - JOUR
T1  - Meta-analysis of Risk Factors for Mortality in Patients with Acinetobacter Baumannii Bloodstream Infection
AU  - Xu Han
AU  - Haiyan Huang
AU  - Weitao Lv
AU  - Wanxian Lu
Y1  - 2021/02/23
PY  - 2021
N1  - https://doi.org/10.11648/j.ajns.20211001.22
DO  - 10.11648/j.ajns.20211001.22
T2  - American Journal of Nursing Science
JF  - American Journal of Nursing Science
JO  - American Journal of Nursing Science
SP  - 64
EP  - 70
PB  - Science Publishing Group
SN  - 2328-5753
UR  - https://doi.org/10.11648/j.ajns.20211001.22
AB  - Background: Patients with Acinetobacter baumannii bloodstream infection (ABBI) have a poor prognosis and high mortality. Early identification of risk factors for death in patients with ABBI, and appropriate prevention and control measures are extremely important to reduce the mortality. Objective: To systematically evaluate the risk factors of ABBI, which provide evidence for reducing the incidence and mortality of patients. Methods: The published articles and reference works on prognosis risk factors in patients with ABBI were retrieved from inception to January 2021 in the following databases: PubMed, Web of Science, Embase, CNKI, Wanfang and VIP. Those studies that met the inclusion criteria were perform quality evaluation and data analysis. Meta-analysis was performed by the statistical software Stata13.0. Results: A total of 24 articles were included, including 1 203 patients in the death group and 1 319 patients in the survival group. Among the 24 included study factors, 15 showed statistically significant differences(PPP=0.03), ICU admission (OR=1.91, 95%CI: 1.12~3.26, P=0.02), shock (OR=4.28, 95% CI: 1.05~17.49, P=0.04), septic shock (OR=8.36, 95%CI: 3.71~18.82, PPP=0.03), malignant tumor (OR=1.56, 95%CI: 1.02~2.37, P=0.04 ), liver disease (OR=1.93, 95%CI: 1.25~3.00, PPPPPPP<0.01). Conclusion: The severity of the patient's underlying disease, using of hormones and immunosuppressants, and various invasive operations were the main risk factors for high mortality in ABBI patients. It was necessary to focus on older patients, dynamically monitor the APACHE II score, carefully evaluate the effect of hormone and immunosuppressant application, and strictly control the indications of invasive operation or treatment.
VL  - 10
IS  - 1
ER  -

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Author Information

Xu Han

Department of Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, China
Haiyan Huang

Department of Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, China
Weitao Lv

Department of Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, China
Wanxian Lu

Department of Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, China

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APA Style

Xu Han, Haiyan Huang, Weitao Lv, Wanxian Lu. (2021). Meta-analysis of Risk Factors for Mortality in Patients with Acinetobacter Baumannii Bloodstream Infection. American Journal of Nursing Science, 10(1), 64-70. https://doi.org/10.11648/j.ajns.20211001.22

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ACS Style

Xu Han; Haiyan Huang; Weitao Lv; Wanxian Lu. Meta-analysis of Risk Factors for Mortality in Patients with Acinetobacter Baumannii Bloodstream Infection. Am. J. Nurs. Sci. 2021, 10(1), 64-70. doi: 10.11648/j.ajns.20211001.22

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AMA Style

Xu Han, Haiyan Huang, Weitao Lv, Wanxian Lu. Meta-analysis of Risk Factors for Mortality in Patients with Acinetobacter Baumannii Bloodstream Infection. Am J Nurs Sci. 2021;10(1):64-70. doi: 10.11648/j.ajns.20211001.22

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@article{10.11648/j.ajns.20211001.22,
  author = {Xu Han and Haiyan Huang and Weitao Lv and Wanxian Lu},
  title = {Meta-analysis of Risk Factors for Mortality in Patients with Acinetobacter Baumannii Bloodstream Infection},
  journal = {American Journal of Nursing Science},
  volume = {10},
  number = {1},
  pages = {64-70},
  doi = {10.11648/j.ajns.20211001.22},
  url = {https://doi.org/10.11648/j.ajns.20211001.22},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajns.20211001.22},
  abstract = {Background: Patients with Acinetobacter baumannii bloodstream infection (ABBI) have a poor prognosis and high mortality. Early identification of risk factors for death in patients with ABBI, and appropriate prevention and control measures are extremely important to reduce the mortality. Objective: To systematically evaluate the risk factors of ABBI, which provide evidence for reducing the incidence and mortality of patients. Methods: The published articles and reference works on prognosis risk factors in patients with ABBI were retrieved from inception to January 2021 in the following databases: PubMed, Web of Science, Embase, CNKI, Wanfang and VIP. Those studies that met the inclusion criteria were perform quality evaluation and data analysis. Meta-analysis was performed by the statistical software Stata13.0. Results: A total of 24 articles were included, including 1 203 patients in the death group and 1 319 patients in the survival group. Among the 24 included study factors, 15 showed statistically significant differences(PPP=0.03), ICU admission (OR=1.91, 95%CI: 1.12~3.26, P=0.02), shock (OR=4.28, 95% CI: 1.05~17.49, P=0.04), septic shock (OR=8.36, 95%CI: 3.71~18.82, PPP=0.03), malignant tumor (OR=1.56, 95%CI: 1.02~2.37, P=0.04 ), liver disease (OR=1.93, 95%CI: 1.25~3.00, PPPPPPP<0.01). Conclusion: The severity of the patient's underlying disease, using of hormones and immunosuppressants, and various invasive operations were the main risk factors for high mortality in ABBI patients. It was necessary to focus on older patients, dynamically monitor the APACHE II score, carefully evaluate the effect of hormone and immunosuppressant application, and strictly control the indications of invasive operation or treatment.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Meta-analysis of Risk Factors for Mortality in Patients with Acinetobacter Baumannii Bloodstream Infection
AU  - Xu Han
AU  - Haiyan Huang
AU  - Weitao Lv
AU  - Wanxian Lu
Y1  - 2021/02/23
PY  - 2021
N1  - https://doi.org/10.11648/j.ajns.20211001.22
DO  - 10.11648/j.ajns.20211001.22
T2  - American Journal of Nursing Science
JF  - American Journal of Nursing Science
JO  - American Journal of Nursing Science
SP  - 64
EP  - 70
PB  - Science Publishing Group
SN  - 2328-5753
UR  - https://doi.org/10.11648/j.ajns.20211001.22
AB  - Background: Patients with Acinetobacter baumannii bloodstream infection (ABBI) have a poor prognosis and high mortality. Early identification of risk factors for death in patients with ABBI, and appropriate prevention and control measures are extremely important to reduce the mortality. Objective: To systematically evaluate the risk factors of ABBI, which provide evidence for reducing the incidence and mortality of patients. Methods: The published articles and reference works on prognosis risk factors in patients with ABBI were retrieved from inception to January 2021 in the following databases: PubMed, Web of Science, Embase, CNKI, Wanfang and VIP. Those studies that met the inclusion criteria were perform quality evaluation and data analysis. Meta-analysis was performed by the statistical software Stata13.0. Results: A total of 24 articles were included, including 1 203 patients in the death group and 1 319 patients in the survival group. Among the 24 included study factors, 15 showed statistically significant differences(PPP=0.03), ICU admission (OR=1.91, 95%CI: 1.12~3.26, P=0.02), shock (OR=4.28, 95% CI: 1.05~17.49, P=0.04), septic shock (OR=8.36, 95%CI: 3.71~18.82, PPP=0.03), malignant tumor (OR=1.56, 95%CI: 1.02~2.37, P=0.04 ), liver disease (OR=1.93, 95%CI: 1.25~3.00, PPPPPPP<0.01). Conclusion: The severity of the patient's underlying disease, using of hormones and immunosuppressants, and various invasive operations were the main risk factors for high mortality in ABBI patients. It was necessary to focus on older patients, dynamically monitor the APACHE II score, carefully evaluate the effect of hormone and immunosuppressant application, and strictly control the indications of invasive operation or treatment.
VL  - 10
IS  - 1
ER  -

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