Age-specific Nursing Management for Sodium Taurocholate Cotransporting Polypeptide Deficiency: 
A Narrative Review

Min Zhu; Shuai Yang; Rui-Lan Cheng; Yuan-Zong Song

doi:doi:10.11648/j.ajns.20261502.13

Review Article |

| Peer-Reviewed

Age-specific Nursing Management for Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Narrative Review

Min Zhu

, Shuai Yang

, Rui-Lan Cheng

, Yuan-Zong Song^*

Published in American Journal of Nursing Science (Volume 15, Issue 2)

Received: 19 March 2026 Accepted: 3 April 2026 Published: 23 April 2026

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Abstract

Background: Sodium taurocholate cotransporting polypeptide (NTCP) deficiency (NTCPD) is a rare hereditary bile acid metabolism disorder caused by mutations in the SLC10A1 gene. Patients exhibit distinct clinical phenotypes across developmental stages, including neonatal cholestatic jaundice and hyperbilirubinemia, toddler-onset pruritus, school-age vitamin D insufficiency, and adult asymptomatic hypercholanemia or intrahepatic cholestasis of pregnancy. High symptom heterogeneity, frequent diagnostic delays, and the absence of standardized age-specific nursing protocols present significant challenges in clinical management. Purpose: This review aims to describe the clinical characteristics and nursing needs of NTCPD patients across the lifespan and to propose a practical, age-specific nursing management framework. Methods: A systematic literature search was conducted across PubMed, CINAHL, Embase, and CNKI in 2025 with no restriction on publication start date; 38 references were ultimately included from 312 initial records, supplemented by evidence from analogous cholestatic conditions where NTCPD-specific data were unavailable. Conclusions: An age-specific nursing management framework covering four developmental stages, with core components encompassing dynamic monitoring of bile acids and fat-soluble vitamins, individualized nutritional support, structured family health education, and caregiver psychological screening. This framework provides a theoretical basis for improving family caregiving capacity and optimizing patient outcomes, while highlighting the urgent need for prospective, multi-center research and the development of NTCPD-specific nursing guideline.

Published in	American Journal of Nursing Science (Volume 15, Issue 2)
DOI	10.11648/j.ajns.20261502.13
Page(s)	35-43
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2026. Published by Science Publishing Group

Keywords

NTCP Deficiency, Age-specific Nursing Care, Bile Acid Metabolism, Symptom Management

References

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APA Style

Zhu, M., Yang, S., Cheng, R., Song, Y. (2026). Age-specific Nursing Management for Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Narrative Review. American Journal of Nursing Science, 15(2), 35-43. https://doi.org/10.11648/j.ajns.20261502.13

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ACS Style

Zhu, M.; Yang, S.; Cheng, R.; Song, Y. Age-specific Nursing Management for Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Narrative Review. Am. J. Nurs. Sci. 2026, 15(2), 35-43. doi: 10.11648/j.ajns.20261502.13

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AMA Style

Zhu M, Yang S, Cheng R, Song Y. Age-specific Nursing Management for Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Narrative Review. Am J Nurs Sci. 2026;15(2):35-43. doi: 10.11648/j.ajns.20261502.13

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@article{10.11648/j.ajns.20261502.13,
  author = {Min Zhu and Shuai Yang and Rui-Lan Cheng and Yuan-Zong Song},
  title = {Age-specific Nursing Management for Sodium Taurocholate Cotransporting Polypeptide Deficiency: 
A Narrative Review},
  journal = {American Journal of Nursing Science},
  volume = {15},
  number = {2},
  pages = {35-43},
  doi = {10.11648/j.ajns.20261502.13},
  url = {https://doi.org/10.11648/j.ajns.20261502.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajns.20261502.13},
  abstract = {Background: Sodium taurocholate cotransporting polypeptide (NTCP) deficiency (NTCPD) is a rare hereditary bile acid metabolism disorder caused by mutations in the SLC10A1 gene. Patients exhibit distinct clinical phenotypes across developmental stages, including neonatal cholestatic jaundice and hyperbilirubinemia, toddler-onset pruritus, school-age vitamin D insufficiency, and adult asymptomatic hypercholanemia or intrahepatic cholestasis of pregnancy. High symptom heterogeneity, frequent diagnostic delays, and the absence of standardized age-specific nursing protocols present significant challenges in clinical management. Purpose: This review aims to describe the clinical characteristics and nursing needs of NTCPD patients across the lifespan and to propose a practical, age-specific nursing management framework. Methods: A systematic literature search was conducted across PubMed, CINAHL, Embase, and CNKI in 2025 with no restriction on publication start date; 38 references were ultimately included from 312 initial records, supplemented by evidence from analogous cholestatic conditions where NTCPD-specific data were unavailable. Conclusions: An age-specific nursing management framework covering four developmental stages, with core components encompassing dynamic monitoring of bile acids and fat-soluble vitamins, individualized nutritional support, structured family health education, and caregiver psychological screening. This framework provides a theoretical basis for improving family caregiving capacity and optimizing patient outcomes, while highlighting the urgent need for prospective, multi-center research and the development of NTCPD-specific nursing guideline.},
 year = {2026}
}

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TY  - JOUR
T1  - Age-specific Nursing Management for Sodium Taurocholate Cotransporting Polypeptide Deficiency: 
A Narrative Review
AU  - Min Zhu
AU  - Shuai Yang
AU  - Rui-Lan Cheng
AU  - Yuan-Zong Song
Y1  - 2026/04/23
PY  - 2026
N1  - https://doi.org/10.11648/j.ajns.20261502.13
DO  - 10.11648/j.ajns.20261502.13
T2  - American Journal of Nursing Science
JF  - American Journal of Nursing Science
JO  - American Journal of Nursing Science
SP  - 35
EP  - 43
PB  - Science Publishing Group
SN  - 2328-5753
UR  - https://doi.org/10.11648/j.ajns.20261502.13
AB  - Background: Sodium taurocholate cotransporting polypeptide (NTCP) deficiency (NTCPD) is a rare hereditary bile acid metabolism disorder caused by mutations in the SLC10A1 gene. Patients exhibit distinct clinical phenotypes across developmental stages, including neonatal cholestatic jaundice and hyperbilirubinemia, toddler-onset pruritus, school-age vitamin D insufficiency, and adult asymptomatic hypercholanemia or intrahepatic cholestasis of pregnancy. High symptom heterogeneity, frequent diagnostic delays, and the absence of standardized age-specific nursing protocols present significant challenges in clinical management. Purpose: This review aims to describe the clinical characteristics and nursing needs of NTCPD patients across the lifespan and to propose a practical, age-specific nursing management framework. Methods: A systematic literature search was conducted across PubMed, CINAHL, Embase, and CNKI in 2025 with no restriction on publication start date; 38 references were ultimately included from 312 initial records, supplemented by evidence from analogous cholestatic conditions where NTCPD-specific data were unavailable. Conclusions: An age-specific nursing management framework covering four developmental stages, with core components encompassing dynamic monitoring of bile acids and fat-soluble vitamins, individualized nutritional support, structured family health education, and caregiver psychological screening. This framework provides a theoretical basis for improving family caregiving capacity and optimizing patient outcomes, while highlighting the urgent need for prospective, multi-center research and the development of NTCPD-specific nursing guideline.
VL  - 15
IS  - 2
ER  -

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Author Information

Min Zhu

School of Nursing, Jinan University, Guangzhou, China

http://orcid.org/0009-0002-5749-9175
Shuai Yang

School of Nursing, Jinan University, Guangzhou, China

http://orcid.org/0000-0002-2616-6979
Rui-Lan Cheng

Department of Pediatrics, The First Affiliated Hospital of Jinan University, Guangzhou, China

http://orcid.org/0009-0008-7626-9053
Yuan-Zong Song

Department of Pediatrics, The First Affiliated Hospital of Jinan University, Guangzhou, China

Contact Email

http://orcid.org/0000-0003-0101-2743

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APA Style

Zhu, M., Yang, S., Cheng, R., Song, Y. (2026). Age-specific Nursing Management for Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Narrative Review. American Journal of Nursing Science, 15(2), 35-43. https://doi.org/10.11648/j.ajns.20261502.13

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ACS Style

Zhu, M.; Yang, S.; Cheng, R.; Song, Y. Age-specific Nursing Management for Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Narrative Review. Am. J. Nurs. Sci. 2026, 15(2), 35-43. doi: 10.11648/j.ajns.20261502.13

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AMA Style

Zhu M, Yang S, Cheng R, Song Y. Age-specific Nursing Management for Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Narrative Review. Am J Nurs Sci. 2026;15(2):35-43. doi: 10.11648/j.ajns.20261502.13

Copy | Download

@article{10.11648/j.ajns.20261502.13,
  author = {Min Zhu and Shuai Yang and Rui-Lan Cheng and Yuan-Zong Song},
  title = {Age-specific Nursing Management for Sodium Taurocholate Cotransporting Polypeptide Deficiency: 
A Narrative Review},
  journal = {American Journal of Nursing Science},
  volume = {15},
  number = {2},
  pages = {35-43},
  doi = {10.11648/j.ajns.20261502.13},
  url = {https://doi.org/10.11648/j.ajns.20261502.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajns.20261502.13},
  abstract = {Background: Sodium taurocholate cotransporting polypeptide (NTCP) deficiency (NTCPD) is a rare hereditary bile acid metabolism disorder caused by mutations in the SLC10A1 gene. Patients exhibit distinct clinical phenotypes across developmental stages, including neonatal cholestatic jaundice and hyperbilirubinemia, toddler-onset pruritus, school-age vitamin D insufficiency, and adult asymptomatic hypercholanemia or intrahepatic cholestasis of pregnancy. High symptom heterogeneity, frequent diagnostic delays, and the absence of standardized age-specific nursing protocols present significant challenges in clinical management. Purpose: This review aims to describe the clinical characteristics and nursing needs of NTCPD patients across the lifespan and to propose a practical, age-specific nursing management framework. Methods: A systematic literature search was conducted across PubMed, CINAHL, Embase, and CNKI in 2025 with no restriction on publication start date; 38 references were ultimately included from 312 initial records, supplemented by evidence from analogous cholestatic conditions where NTCPD-specific data were unavailable. Conclusions: An age-specific nursing management framework covering four developmental stages, with core components encompassing dynamic monitoring of bile acids and fat-soluble vitamins, individualized nutritional support, structured family health education, and caregiver psychological screening. This framework provides a theoretical basis for improving family caregiving capacity and optimizing patient outcomes, while highlighting the urgent need for prospective, multi-center research and the development of NTCPD-specific nursing guideline.},
 year = {2026}
}

Copy | Download

TY  - JOUR
T1  - Age-specific Nursing Management for Sodium Taurocholate Cotransporting Polypeptide Deficiency: 
A Narrative Review
AU  - Min Zhu
AU  - Shuai Yang
AU  - Rui-Lan Cheng
AU  - Yuan-Zong Song
Y1  - 2026/04/23
PY  - 2026
N1  - https://doi.org/10.11648/j.ajns.20261502.13
DO  - 10.11648/j.ajns.20261502.13
T2  - American Journal of Nursing Science
JF  - American Journal of Nursing Science
JO  - American Journal of Nursing Science
SP  - 35
EP  - 43
PB  - Science Publishing Group
SN  - 2328-5753
UR  - https://doi.org/10.11648/j.ajns.20261502.13
AB  - Background: Sodium taurocholate cotransporting polypeptide (NTCP) deficiency (NTCPD) is a rare hereditary bile acid metabolism disorder caused by mutations in the SLC10A1 gene. Patients exhibit distinct clinical phenotypes across developmental stages, including neonatal cholestatic jaundice and hyperbilirubinemia, toddler-onset pruritus, school-age vitamin D insufficiency, and adult asymptomatic hypercholanemia or intrahepatic cholestasis of pregnancy. High symptom heterogeneity, frequent diagnostic delays, and the absence of standardized age-specific nursing protocols present significant challenges in clinical management. Purpose: This review aims to describe the clinical characteristics and nursing needs of NTCPD patients across the lifespan and to propose a practical, age-specific nursing management framework. Methods: A systematic literature search was conducted across PubMed, CINAHL, Embase, and CNKI in 2025 with no restriction on publication start date; 38 references were ultimately included from 312 initial records, supplemented by evidence from analogous cholestatic conditions where NTCPD-specific data were unavailable. Conclusions: An age-specific nursing management framework covering four developmental stages, with core components encompassing dynamic monitoring of bile acids and fat-soluble vitamins, individualized nutritional support, structured family health education, and caregiver psychological screening. This framework provides a theoretical basis for improving family caregiving capacity and optimizing patient outcomes, while highlighting the urgent need for prospective, multi-center research and the development of NTCPD-specific nursing guideline.
VL  - 15
IS  - 2
ER  -

Copy | Download