Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma

Liu Xiaolong; Cheng Changhe

doi:doi:10.11648/j.crj.20241201.11

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Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma

Liu Xiaolong, Cheng Changhe^*

Published in Cancer Research Journal (Volume 12, Issue 1)

Received: 19 December 2023 Accepted: 2 January 2024 Published: 11 January 2024

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Abstract

The Helicobacter infection was caused many diseases, and found in the liver tissue of primary liver cancer patients. Liver cancer was seriously dangerous of healthy, it confirmed that the correlation between liver cancer and multiple viruses, such as HBV and HCV, even include helicobacter. In this study, we explored the association between helicobacter and primary liver carcinoma. by searching relevant literature with database. The separated case-control studies on relationship between helicobacter infection and primary liver carcinoma were analyzed by Meta-analysis with Revman 5.0. 9 studies were included in the final analysis. Overall the prevalence of helicobacter infection was 52.53% (166 of 316) in case group vs 9.96% (23 of 231) in control group, and the summary odds ratio for the association of helicobacter infection with the risk for primary liver carcinoma (using the fixed-effects model, which accounted for the homogeneity across the 9 studies) was determined to be odds ratio 14.19 (95% CI, 7.92～15.14). Sensitivity analysis showed the results were no publication bias.the funnel plot was approximately standard symmetric, Failure safety number (Nfs) analysis: Calculate Nfs at P=0.05 level, Nfs 0.05=( Σ Z/1.64) 2-K=369.395, the large Nfs value also indicateed that there was no publication bias in the study. So the Meta-analysis demonstrated there was a positive association between helicobacter infection and the risk of primary liver carcinoma.

Published in	Cancer Research Journal (Volume 12, Issue 1)
DOI	10.11648/j.crj.20241201.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Helicobacter, Primary Liver Cancer, Meta Analysis

References

[1]	Murakami K, Takahashi R, Ono M, et al. Serodiagnosis of Helicobacter hepaticus infection in patients with liver and gastrointestinal diseases: western blot analysis and ELISA using a highly specific monoclonal antibody for H. hepaticus antigen [J]. J Gastroenterol 2011; 46(9): 1120-1126.
[2]	Pandcy M Shulda M Helicobacter species are associated with possible increase in risk of hepatobiliary tract cancers [J]. Surg Oncol, 2009, 18(1): 51-6.
[3]	Wang L, Zollinger T, Zhang JJ. Association between Helicobacter pylori infection and liver cancer mortality in 67 rural Chinese counties [J]. Cancer Causes & Control, 2013, 24 (7): 1331-1337.
[4]	CHEN Yan-ling, YE Jing-min, SHE Fei-fei, et al. Detection and analysis of Helicobacter species in liver tissue from patients with primary hepatocellular carcinoma [J]. Chin J Hepatobiliary Surg, 2007, 13(10): 667-671.
[5]	CHEN Ren, CHEN Xiao- ping, LIN Bing-liang, et al. Status of H. pylori infection in the hepatic tissue of patients with hepatocarcinoma [J]. J South Med Univ, 2010, 30(5): 1028-1030.
[6]	Jl Yang, S W Ji, YG Zhang, et al. Helicobacter hepaticus infection in primary hepatocellular carcinoma tissue [J]. Singapore Med J 2013; 54(8): 451-457.
[7]	LI Ning, ZHAN Shu-hui, XUAN Ahi-ying, QIANG Xin, et al. Study on Helicobacter infection in liver tissue from hepatocellular carcinoma [J]. Chin Epideniol, 2006, 27(10): 894-896.
[8]	Rocha M, Avenaud P, Ménard A, et al. Association of Helicobacter species with hepatitis C cirrhosis with or without hepatocellular carcinoma [J]. Gut, 2005, 54(3): 396-401.
[9]	Rinaldo Pellicano, Vincenzo Mazzaferro, et al. Helicobacter species sequences in liver samples from patients with and without hepatocellular carcinoma [J]. World J Gastroenterol 2004; 10(4): 598-601.
[10]	Shi Xuan, N Li, X Qiang, et al. Helicobacter infection in hepatocellular carcinoma tissue [J]. World J Gastroenterol 2006, 12(15): 2335-2340.
[11]	Y Huang, X-G Fan, Z-M Wang, et al. Identification of helicobacter species in human liver samples from patients with primary hepatocellular carcinoma [J]. J Clin Pathol 2004; 57(12): 1273–1277.
[12]	ZHANG Shi-qiang, BAO Yong, ZU Mao-heng. Study the correlation of between Helicobacter pylori infection and primary liver cancer [J]. Chin J Clin Oncol, 2004, 31(13): 761-764.
[13]	Castéra L, Pedeboscq A, Rocha M, et al. Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: a prospective study [J]. World J Gastroenterol 2006; 12(45): 7278-7284.

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APA Style

Xiaolong, L., Changhe, C. (2024). Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma. Cancer Research Journal, 12(1), 1-4. https://doi.org/10.11648/j.crj.20241201.11

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ACS Style

Xiaolong, L.; Changhe, C. Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma. Cancer Res. J. 2024, 12(1), 1-4. doi: 10.11648/j.crj.20241201.11

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AMA Style

Xiaolong L, Changhe C. Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma. Cancer Res J. 2024;12(1):1-4. doi: 10.11648/j.crj.20241201.11

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@article{10.11648/j.crj.20241201.11,
  author = {Liu Xiaolong and Cheng Changhe},
  title = {Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma},
  journal = {Cancer Research Journal},
  volume = {12},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.crj.20241201.11},
  url = {https://doi.org/10.11648/j.crj.20241201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20241201.11},
  abstract = {The Helicobacter infection was caused many diseases, and found in the liver tissue of primary liver cancer patients. Liver cancer was seriously dangerous of healthy, it confirmed that the correlation between liver cancer and multiple viruses, such as HBV and HCV, even include helicobacter. In this study, we explored the association between helicobacter and primary liver carcinoma. by searching relevant literature with database. The separated case-control studies on relationship between helicobacter infection and primary liver carcinoma were analyzed by Meta-analysis with Revman 5.0. 9 studies were included in the final analysis. Overall the prevalence of helicobacter infection was 52.53% (166 of 316) in case group vs 9.96% (23 of 231) in control group, and the summary odds ratio for the association of helicobacter infection with the risk for primary liver carcinoma (using the fixed-effects model, which accounted for the homogeneity across the 9 studies) was determined to be odds ratio 14.19 (95% CI, 7.92～15.14). Sensitivity analysis showed the results were no publication bias.the funnel plot was approximately standard symmetric, Failure safety number (Nfs) analysis: Calculate Nfs at P=0.05 level, Nfs 0.05=( Σ Z/1.64) 2-K=369.395, the large Nfs value also indicateed that there was no publication bias in the study. So the Meta-analysis demonstrated there was a positive association between helicobacter infection and the risk of primary liver carcinoma.
},
 year = {2024}
}

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TY  - JOUR
T1  - Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma
AU  - Liu Xiaolong
AU  - Cheng Changhe
Y1  - 2024/01/11
PY  - 2024
N1  - https://doi.org/10.11648/j.crj.20241201.11
DO  - 10.11648/j.crj.20241201.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20241201.11
AB  - The Helicobacter infection was caused many diseases, and found in the liver tissue of primary liver cancer patients. Liver cancer was seriously dangerous of healthy, it confirmed that the correlation between liver cancer and multiple viruses, such as HBV and HCV, even include helicobacter. In this study, we explored the association between helicobacter and primary liver carcinoma. by searching relevant literature with database. The separated case-control studies on relationship between helicobacter infection and primary liver carcinoma were analyzed by Meta-analysis with Revman 5.0. 9 studies were included in the final analysis. Overall the prevalence of helicobacter infection was 52.53% (166 of 316) in case group vs 9.96% (23 of 231) in control group, and the summary odds ratio for the association of helicobacter infection with the risk for primary liver carcinoma (using the fixed-effects model, which accounted for the homogeneity across the 9 studies) was determined to be odds ratio 14.19 (95% CI, 7.92～15.14). Sensitivity analysis showed the results were no publication bias.the funnel plot was approximately standard symmetric, Failure safety number (Nfs) analysis: Calculate Nfs at P=0.05 level, Nfs 0.05=( Σ Z/1.64) 2-K=369.395, the large Nfs value also indicateed that there was no publication bias in the study. So the Meta-analysis demonstrated there was a positive association between helicobacter infection and the risk of primary liver carcinoma.

VL  - 12
IS  - 1
ER  -

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Author Information

Liu Xiaolong

Department of Basic Medicine, Jiang Xi Medical College, Shangrao, China
Cheng Changhe

Department of Pharmacy, Jiang Xi Medical College, Shangrao, China

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APA Style

Xiaolong, L., Changhe, C. (2024). Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma. Cancer Research Journal, 12(1), 1-4. https://doi.org/10.11648/j.crj.20241201.11

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ACS Style

Xiaolong, L.; Changhe, C. Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma. Cancer Res. J. 2024, 12(1), 1-4. doi: 10.11648/j.crj.20241201.11

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AMA Style

Xiaolong L, Changhe C. Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma. Cancer Res J. 2024;12(1):1-4. doi: 10.11648/j.crj.20241201.11

Copy | Download

@article{10.11648/j.crj.20241201.11,
  author = {Liu Xiaolong and Cheng Changhe},
  title = {Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma},
  journal = {Cancer Research Journal},
  volume = {12},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.crj.20241201.11},
  url = {https://doi.org/10.11648/j.crj.20241201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20241201.11},
  abstract = {The Helicobacter infection was caused many diseases, and found in the liver tissue of primary liver cancer patients. Liver cancer was seriously dangerous of healthy, it confirmed that the correlation between liver cancer and multiple viruses, such as HBV and HCV, even include helicobacter. In this study, we explored the association between helicobacter and primary liver carcinoma. by searching relevant literature with database. The separated case-control studies on relationship between helicobacter infection and primary liver carcinoma were analyzed by Meta-analysis with Revman 5.0. 9 studies were included in the final analysis. Overall the prevalence of helicobacter infection was 52.53% (166 of 316) in case group vs 9.96% (23 of 231) in control group, and the summary odds ratio for the association of helicobacter infection with the risk for primary liver carcinoma (using the fixed-effects model, which accounted for the homogeneity across the 9 studies) was determined to be odds ratio 14.19 (95% CI, 7.92～15.14). Sensitivity analysis showed the results were no publication bias.the funnel plot was approximately standard symmetric, Failure safety number (Nfs) analysis: Calculate Nfs at P=0.05 level, Nfs 0.05=( Σ Z/1.64) 2-K=369.395, the large Nfs value also indicateed that there was no publication bias in the study. So the Meta-analysis demonstrated there was a positive association between helicobacter infection and the risk of primary liver carcinoma.
},
 year = {2024}
}

Copy | Download

TY  - JOUR
T1  - Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma
AU  - Liu Xiaolong
AU  - Cheng Changhe
Y1  - 2024/01/11
PY  - 2024
N1  - https://doi.org/10.11648/j.crj.20241201.11
DO  - 10.11648/j.crj.20241201.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20241201.11
AB  - The Helicobacter infection was caused many diseases, and found in the liver tissue of primary liver cancer patients. Liver cancer was seriously dangerous of healthy, it confirmed that the correlation between liver cancer and multiple viruses, such as HBV and HCV, even include helicobacter. In this study, we explored the association between helicobacter and primary liver carcinoma. by searching relevant literature with database. The separated case-control studies on relationship between helicobacter infection and primary liver carcinoma were analyzed by Meta-analysis with Revman 5.0. 9 studies were included in the final analysis. Overall the prevalence of helicobacter infection was 52.53% (166 of 316) in case group vs 9.96% (23 of 231) in control group, and the summary odds ratio for the association of helicobacter infection with the risk for primary liver carcinoma (using the fixed-effects model, which accounted for the homogeneity across the 9 studies) was determined to be odds ratio 14.19 (95% CI, 7.92～15.14). Sensitivity analysis showed the results were no publication bias.the funnel plot was approximately standard symmetric, Failure safety number (Nfs) analysis: Calculate Nfs at P=0.05 level, Nfs 0.05=( Σ Z/1.64) 2-K=369.395, the large Nfs value also indicateed that there was no publication bias in the study. So the Meta-analysis demonstrated there was a positive association between helicobacter infection and the risk of primary liver carcinoma.

VL  - 12
IS  - 1
ER  -

Copy | Download