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Research Article | | Peer-Reviewed

Causal Role of Immune Cells in Inflammatory Bowel Disease: A Mendelian Randomization (MR) Study

Heng Shi,  Qin Peng*
Published in International Journal of Gastroenterology (Volume 9, Issue 1)
Received: 26 March 2025     Accepted: 10 April 2025     Published: 29 April 2025
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Abstract

The present Mendelian randomization study investigated the potential causal relationship between immunophenotypes and inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). Results demonstrated that immunophenotypes, such as CD28 on CD39+ resting Treg and CD25 on IgD+ CD24− showed nominal significant protective effects on CD and UC, respectively. Conversely, specific immunophenotypes also exhibited nominal significant risk effects on CD and UC, including CD39 on CD39+ CD8br and IgD on IgD+ CD38dim, respectively. Collectively, our findings highlight the potential role of immune cell phenotypes in the development of CD and UC as evidenced by data analysis from the FinnGen database. Therefore, the present study contributes to understanding the genetic basis of IBD and highlights the significance of immune cell phenotypes in disease pathogenesis.

Published in International Journal of Gastroenterology (Volume 9, Issue 1)
DOI 10.11648/j.ijg.20250901.14
Page(s) 25-31
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

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Copyright © The Author(s), 2025. Published by Science Publishing Group
Previous article
Keywords

Inflammatory Bowel Diseases, Crohn’s Disease, Ulcerative Colitis, Immunity, MR Analysis

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    Shi, H., Peng, Q. (2025). Causal Role of Immune Cells in Inflammatory Bowel Disease: A Mendelian Randomization (MR) Study. International Journal of Gastroenterology, 9(1), 25-31. https://doi.org/10.11648/j.ijg.20250901.14

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    ACS Style

    Shi, H.; Peng, Q. Causal Role of Immune Cells in Inflammatory Bowel Disease: A Mendelian Randomization (MR) Study. Int. J. Gastroenterol. 2025, 9(1), 25-31. doi: 10.11648/j.ijg.20250901.14

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    AMA Style

    Shi H, Peng Q. Causal Role of Immune Cells in Inflammatory Bowel Disease: A Mendelian Randomization (MR) Study. Int J Gastroenterol. 2025;9(1):25-31. doi: 10.11648/j.ijg.20250901.14

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  • @article{10.11648/j.ijg.20250901.14,
  author = {Heng Shi and Qin Peng},
  title = {Causal Role of Immune Cells in Inflammatory Bowel Disease: A Mendelian Randomization (MR) Study
},
  journal = {International Journal of Gastroenterology},
  volume = {9},
  number = {1},
  pages = {25-31},
  doi = {10.11648/j.ijg.20250901.14},
  url = {https://doi.org/10.11648/j.ijg.20250901.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20250901.14},
  abstract = {The present Mendelian randomization study investigated the potential causal relationship between immunophenotypes and inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). Results demonstrated that immunophenotypes, such as CD28 on CD39+ resting Treg and CD25 on IgD+ CD24− showed nominal significant protective effects on CD and UC, respectively. Conversely, specific immunophenotypes also exhibited nominal significant risk effects on CD and UC, including CD39 on CD39+ CD8br and IgD on IgD+ CD38dim, respectively. Collectively, our findings highlight the potential role of immune cell phenotypes in the development of CD and UC as evidenced by data analysis from the FinnGen database. Therefore, the present study contributes to understanding the genetic basis of IBD and highlights the significance of immune cell phenotypes in disease pathogenesis.
},
 year = {2025}
}

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  • TY  - JOUR
T1  - Causal Role of Immune Cells in Inflammatory Bowel Disease: A Mendelian Randomization (MR) Study

AU  - Heng Shi
AU  - Qin Peng
Y1  - 2025/04/29
PY  - 2025
N1  - https://doi.org/10.11648/j.ijg.20250901.14
DO  - 10.11648/j.ijg.20250901.14
T2  - International Journal of Gastroenterology
JF  - International Journal of Gastroenterology
JO  - International Journal of Gastroenterology
SP  - 25
EP  - 31
PB  - Science Publishing Group
SN  - 2640-169X
UR  - https://doi.org/10.11648/j.ijg.20250901.14
AB  - The present Mendelian randomization study investigated the potential causal relationship between immunophenotypes and inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). Results demonstrated that immunophenotypes, such as CD28 on CD39+ resting Treg and CD25 on IgD+ CD24− showed nominal significant protective effects on CD and UC, respectively. Conversely, specific immunophenotypes also exhibited nominal significant risk effects on CD and UC, including CD39 on CD39+ CD8br and IgD on IgD+ CD38dim, respectively. Collectively, our findings highlight the potential role of immune cell phenotypes in the development of CD and UC as evidenced by data analysis from the FinnGen database. Therefore, the present study contributes to understanding the genetic basis of IBD and highlights the significance of immune cell phenotypes in disease pathogenesis.

VL  - 9
IS  - 1
ER  -

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