@article{10.11648/j.ijidt.20220702.13,
  author = {Nahom Fessehaye and Oliver Okoth Achila and Yafet Kesete and Feven Mekonen and Lidya Woldemariam and Habte Mehari and Natnael Meles and Lidia Libsekal and Solomon Habtemichael and Yacob Brhane},
  title = {Prevalence of Hepatitis B and C Viruses and Associated Risk Factors in Patients Suspected of Liver Diseases in Asmara, Eritrea},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {7},
  number = {2},
  pages = {35-42},
  doi = {10.11648/j.ijidt.20220702.13},
  url = {https://doi.org/10.11648/j.ijidt.20220702.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20220702.13},
  abstract = {Background: Viral hepatitis is a critical global health challenge and acquiring adequate and recent epidemiological data on Hepatitis B and C infections is important in prevention and control of the disease. The aim of this study is to determine the prevalence and risk factors related with HBV and HCV infection and associated liver enzymes profile among patients suspected of liver diseases in Asmara, Eritrea. Methods: This was a cross-sectional study carried out among patients suspected of liver diseases. 411 participants were screened for serological markers of anti-HCV and HBsAg using rapid assays which were further confirmed using ELISA. A predesigned structured questionnaire was used to collect socio-demographic and risk factors data. Liver function tests were also performed using an automated spectrophotometer analyzer. Furthermore, for every HBV and HCV positive samples viral load was determined. Collected data were then analyzed using SPSS statistical tool. Result: The overall prevalence of HBV and HCV among study participants was 6.6% and 1.7% respectively. Hepatitis virus positive participants had substantially higher mean values of AST, ALT, ALP, total bilirubin and GGT. Viral load mean assay level was 10.6 x 106 IU/ml ranging from 20 IU/ml - 1.7 x 108 IU/ml. There was a significant association between HBsAg and sex (cOR= 4.18, 95% CI: 1.65-10.6), residence area (cOR=2.51, 95% CI: 1.10-5.69). Multivariate logistic analysis showed males were more prone to HBsAg infection (AOR= 3.9; 95% CI: 1.5-10.0). Moreover, prevalence of liver enzyme abnormality was 8.5% (95% CI: 6.1%-8.2%). Among these patients, 24 (5.8%) had cholestatic type, 4 (1%) had hepatocellular, and the rest 7 (1.7%) had mixed type of hepatotoxicity. Conclusion: Though the prevalence of HBV and HCV infection is comparatively low, regular surveillance should be conducted to prevent further spread of disease and achieve global goals of HBV and HCV elimination.},
 year = {2022}
}

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TY  - JOUR
T1  - Prevalence of Hepatitis B and C Viruses and Associated Risk Factors in Patients Suspected of Liver Diseases in Asmara, Eritrea
AU  - Nahom Fessehaye
AU  - Oliver Okoth Achila
AU  - Yafet Kesete
AU  - Feven Mekonen
AU  - Lidya Woldemariam
AU  - Habte Mehari
AU  - Natnael Meles
AU  - Lidia Libsekal
AU  - Solomon Habtemichael
AU  - Yacob Brhane
Y1  - 2022/06/16
PY  - 2022
N1  - https://doi.org/10.11648/j.ijidt.20220702.13
DO  - 10.11648/j.ijidt.20220702.13
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 35
EP  - 42
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20220702.13
AB  - Background: Viral hepatitis is a critical global health challenge and acquiring adequate and recent epidemiological data on Hepatitis B and C infections is important in prevention and control of the disease. The aim of this study is to determine the prevalence and risk factors related with HBV and HCV infection and associated liver enzymes profile among patients suspected of liver diseases in Asmara, Eritrea. Methods: This was a cross-sectional study carried out among patients suspected of liver diseases. 411 participants were screened for serological markers of anti-HCV and HBsAg using rapid assays which were further confirmed using ELISA. A predesigned structured questionnaire was used to collect socio-demographic and risk factors data. Liver function tests were also performed using an automated spectrophotometer analyzer. Furthermore, for every HBV and HCV positive samples viral load was determined. Collected data were then analyzed using SPSS statistical tool. Result: The overall prevalence of HBV and HCV among study participants was 6.6% and 1.7% respectively. Hepatitis virus positive participants had substantially higher mean values of AST, ALT, ALP, total bilirubin and GGT. Viral load mean assay level was 10.6 x 106 IU/ml ranging from 20 IU/ml - 1.7 x 108 IU/ml. There was a significant association between HBsAg and sex (cOR= 4.18, 95% CI: 1.65-10.6), residence area (cOR=2.51, 95% CI: 1.10-5.69). Multivariate logistic analysis showed males were more prone to HBsAg infection (AOR= 3.9; 95% CI: 1.5-10.0). Moreover, prevalence of liver enzyme abnormality was 8.5% (95% CI: 6.1%-8.2%). Among these patients, 24 (5.8%) had cholestatic type, 4 (1%) had hepatocellular, and the rest 7 (1.7%) had mixed type of hepatotoxicity. Conclusion: Though the prevalence of HBV and HCV infection is comparatively low, regular surveillance should be conducted to prevent further spread of disease and achieve global goals of HBV and HCV elimination.
VL  - 7
IS  - 2
ER  - 

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