Preparation and Characterization of Porous Scaffold Composite Films by Blending Carboxymethyl Chitosan and Gelatin for Tissue Engineering

Nisat Tamanna Nipu; Farzana Khan Rony; Asaduz Zaman

doi:doi:10.11648/j.ijmsa.20180702.15

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Preparation and Characterization of Porous Scaffold Composite Films by Blending Carboxymethyl Chitosan and Gelatin for Tissue Engineering

Nisat Tamanna Nipu, Farzana Khan Rony, Asaduz Zaman

Published in International Journal of Materials Science and Applications (Volume 7, Issue 2)

Received: 23 February 2018 Accepted: 9 March 2018 Published: 2 April 2018

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Abstract

In this research work, gelatin-carboxymethylchitosan (CMC) based biodegradable composites films were prepared by solution casting method. Chitosan from waste prawn shell was the basic raw materials of CMC synthesis. Five sets of CMC-gelatin composites (5-25 wt% CMC) along-with pure gelatin were prepared in solution casting method. Incorporation of CMC into gelatin significantly altered some of the properties. The CMC and gelatin-CMC composites formation was confirmed by Fourier Transform Infrared Spectroscopy (FTIR). Surface morphology of the films was investigated by Scanning Electron Microscopy (SEM) and SEM micrograph revealed that composites were porous and CMC was homogenously dispersed into gelatin. The porous surface of the composites is one of the criterions for new cells growth. Thermal stability of composites were investigated by thermogravimetric analysis (TGA) and composites more thermal stable (less weight loss) than pure gelatin. Antimicrobial and cytotoxicity tests found all composites were performed microbial safe and no cytotoxic effect. The physico-chemical analyses and others analyses of scaffolds revealed for their application as a wound dressing material or artificial skin.

Published in	International Journal of Materials Science and Applications (Volume 7, Issue 2)
DOI	10.11648/j.ijmsa.20180702.15
Page(s)	62-68
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Carboxymethyl Chitosan, Gelatin, Scaffold, Cytotoxicity and Tissue Engineering

References

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APA Style

Nisat Tamanna Nipu, Farzana Khan Rony, Asaduz Zaman. (2018). Preparation and Characterization of Porous Scaffold Composite Films by Blending Carboxymethyl Chitosan and Gelatin for Tissue Engineering. International Journal of Materials Science and Applications, 7(2), 62-68. https://doi.org/10.11648/j.ijmsa.20180702.15

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ACS Style

Nisat Tamanna Nipu; Farzana Khan Rony; Asaduz Zaman. Preparation and Characterization of Porous Scaffold Composite Films by Blending Carboxymethyl Chitosan and Gelatin for Tissue Engineering. Int. J. Mater. Sci. Appl. 2018, 7(2), 62-68. doi: 10.11648/j.ijmsa.20180702.15

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AMA Style

Nisat Tamanna Nipu, Farzana Khan Rony, Asaduz Zaman. Preparation and Characterization of Porous Scaffold Composite Films by Blending Carboxymethyl Chitosan and Gelatin for Tissue Engineering. Int J Mater Sci Appl. 2018;7(2):62-68. doi: 10.11648/j.ijmsa.20180702.15

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@article{10.11648/j.ijmsa.20180702.15,
  author = {Nisat Tamanna Nipu and Farzana Khan Rony and Asaduz Zaman},
  title = {Preparation and Characterization of Porous Scaffold Composite Films by Blending Carboxymethyl Chitosan and Gelatin for Tissue Engineering},
  journal = {International Journal of Materials Science and Applications},
  volume = {7},
  number = {2},
  pages = {62-68},
  doi = {10.11648/j.ijmsa.20180702.15},
  url = {https://doi.org/10.11648/j.ijmsa.20180702.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmsa.20180702.15},
  abstract = {In this research work, gelatin-carboxymethylchitosan (CMC) based biodegradable composites films were prepared by solution casting method. Chitosan from waste prawn shell was the basic raw materials of CMC synthesis. Five sets of CMC-gelatin composites (5-25 wt% CMC) along-with pure gelatin were prepared in solution casting method. Incorporation of CMC into gelatin significantly altered some of the properties. The CMC and gelatin-CMC composites formation was confirmed by Fourier Transform Infrared Spectroscopy (FTIR). Surface morphology of the films was investigated by Scanning Electron Microscopy (SEM) and SEM micrograph revealed that composites were porous and CMC was homogenously dispersed into gelatin. The porous surface of the composites is one of the criterions for new cells growth. Thermal stability of composites were investigated by thermogravimetric analysis (TGA) and composites more thermal stable (less weight loss) than pure gelatin. Antimicrobial and cytotoxicity tests found all composites were performed microbial safe and no cytotoxic effect. The physico-chemical analyses and others analyses of scaffolds revealed for their application as a wound dressing material or artificial skin.},
 year = {2018}
}

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TY - JOUR
T1 - Preparation and Characterization of Porous Scaffold Composite Films by Blending Carboxymethyl Chitosan and Gelatin for Tissue Engineering
AU - Nisat Tamanna Nipu
AU - Farzana Khan Rony
AU - Asaduz Zaman
Y1 - 2018/04/02
PY - 2018
N1 - https://doi.org/10.11648/j.ijmsa.20180702.15
DO - 10.11648/j.ijmsa.20180702.15
T2 - International Journal of Materials Science and Applications
JF - International Journal of Materials Science and Applications
JO - International Journal of Materials Science and Applications
SP - 62
EP - 68
PB - Science Publishing Group
SN - 2327-2643
UR - https://doi.org/10.11648/j.ijmsa.20180702.15
AB - In this research work, gelatin-carboxymethylchitosan (CMC) based biodegradable composites films were prepared by solution casting method. Chitosan from waste prawn shell was the basic raw materials of CMC synthesis. Five sets of CMC-gelatin composites (5-25 wt% CMC) along-with pure gelatin were prepared in solution casting method. Incorporation of CMC into gelatin significantly altered some of the properties. The CMC and gelatin-CMC composites formation was confirmed by Fourier Transform Infrared Spectroscopy (FTIR). Surface morphology of the films was investigated by Scanning Electron Microscopy (SEM) and SEM micrograph revealed that composites were porous and CMC was homogenously dispersed into gelatin. The porous surface of the composites is one of the criterions for new cells growth. Thermal stability of composites were investigated by thermogravimetric analysis (TGA) and composites more thermal stable (less weight loss) than pure gelatin. Antimicrobial and cytotoxicity tests found all composites were performed microbial safe and no cytotoxic effect. The physico-chemical analyses and others analyses of scaffolds revealed for their application as a wound dressing material or artificial skin.
VL - 7
IS - 2
ER -

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Author Information

Nisat Tamanna Nipu

Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka, Bangladesh
Farzana Khan Rony

Institute of Glass and Ceramic Research and Testing, Bangladesh Council of Scientific and Industrial Research, Dhaka, Bangladesh
Asaduz Zaman

Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka, Bangladesh

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APA Style

Nisat Tamanna Nipu, Farzana Khan Rony, Asaduz Zaman. (2018). Preparation and Characterization of Porous Scaffold Composite Films by Blending Carboxymethyl Chitosan and Gelatin for Tissue Engineering. International Journal of Materials Science and Applications, 7(2), 62-68. https://doi.org/10.11648/j.ijmsa.20180702.15

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ACS Style

Nisat Tamanna Nipu; Farzana Khan Rony; Asaduz Zaman. Preparation and Characterization of Porous Scaffold Composite Films by Blending Carboxymethyl Chitosan and Gelatin for Tissue Engineering. Int. J. Mater. Sci. Appl. 2018, 7(2), 62-68. doi: 10.11648/j.ijmsa.20180702.15

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AMA Style

Nisat Tamanna Nipu, Farzana Khan Rony, Asaduz Zaman. Preparation and Characterization of Porous Scaffold Composite Films by Blending Carboxymethyl Chitosan and Gelatin for Tissue Engineering. Int J Mater Sci Appl. 2018;7(2):62-68. doi: 10.11648/j.ijmsa.20180702.15

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@article{10.11648/j.ijmsa.20180702.15,
  author = {Nisat Tamanna Nipu and Farzana Khan Rony and Asaduz Zaman},
  title = {Preparation and Characterization of Porous Scaffold Composite Films by Blending Carboxymethyl Chitosan and Gelatin for Tissue Engineering},
  journal = {International Journal of Materials Science and Applications},
  volume = {7},
  number = {2},
  pages = {62-68},
  doi = {10.11648/j.ijmsa.20180702.15},
  url = {https://doi.org/10.11648/j.ijmsa.20180702.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmsa.20180702.15},
  abstract = {In this research work, gelatin-carboxymethylchitosan (CMC) based biodegradable composites films were prepared by solution casting method. Chitosan from waste prawn shell was the basic raw materials of CMC synthesis. Five sets of CMC-gelatin composites (5-25 wt% CMC) along-with pure gelatin were prepared in solution casting method. Incorporation of CMC into gelatin significantly altered some of the properties. The CMC and gelatin-CMC composites formation was confirmed by Fourier Transform Infrared Spectroscopy (FTIR). Surface morphology of the films was investigated by Scanning Electron Microscopy (SEM) and SEM micrograph revealed that composites were porous and CMC was homogenously dispersed into gelatin. The porous surface of the composites is one of the criterions for new cells growth. Thermal stability of composites were investigated by thermogravimetric analysis (TGA) and composites more thermal stable (less weight loss) than pure gelatin. Antimicrobial and cytotoxicity tests found all composites were performed microbial safe and no cytotoxic effect. The physico-chemical analyses and others analyses of scaffolds revealed for their application as a wound dressing material or artificial skin.},
 year = {2018}
}

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