Nano-hydroxyapatite Use in Oral Medicine: A Review

Si-Yu Tao; Fei-Fei Wang; Kashaf Naz; Xue-Jing Lin; Xin-Hui Xu; Yong-Chao Zhao; Xu-Cheng Hu; Bin Liu; Sheng-Ping Cao; Zhu-Ling Guo

doi:doi:10.11648/j.ijmsa.20221103.11

Nano-hydroxyapatite Use in Oral Medicine: A Review

Si-Yu Tao, Fei-Fei Wang, Kashaf Naz, Xue-Jing Lin, Xin-Hui Xu, Yong-Chao Zhao, Xu-Cheng Hu, Bin Liu, Sheng-Ping Cao, Zhu-Ling Guo

Published in International Journal of Materials Science and Applications (Volume 11, Issue 3)

Received: 24 May 2022 Accepted: 7 June 2022 Published: 14 June 2022

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Nano-hydroxyapatite (nHA) are fine particles, and its crystal structure is similar to the inorganic composition of natural bone, similar to ordinary hydroxyapatite, nHA has higher solubility biocompatibility and excellent osteogenicity, especially in repair of bone defects. In recent years, nHA as a new oral material is widely used in various fields of stomatology. The application of nano-hydroxyapatite in dental pulp, Periodontal field, maxillofacial surgery and oral health care is discussed in this paper. We describe by this article that nHA as root canal paste filling is anti-inflammatory and promote the closure of apical foramen. nHA can promote regeneration of alveolar bone cementum and periodontal membrane to form healthy periodontal tissue. nHA can also be widely used in the repair of oral bone tissue defects such as periodontal bone defect, alveolar bone reconstruction and jaw cyst. Besides, in the field of surgery, nHA can be used in defected bone area caused by surgery, it can promote bone union. In the field of oral health care, nHA can inhibit the formation of dental plaque, promote enamel remineralization, whiten teeth and relieve dentin sensitivity when applied to toothpaste, mouthwash and oral spray. The aim of this study is to provide a broad understanding of nHA and promote the use of nHA materials in the treatment of oral disease.

Published in	International Journal of Materials Science and Applications (Volume 11, Issue 3)
DOI	10.11648/j.ijmsa.20221103.11
Page(s)	62-65
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Nano, Hydroxyapatite, Oral Materials, Re-mineralization, Bone Repair

References

[1]	Dau M. Kammerer PW. Henkel KO. et al. Bone formation in mono cortical mandibular critical size defects after augmentation with two synthetic nano stuctured and one xenogenous hydroxyapatite bone substitute-in vivo animal study [J]. Clin Oral Implants Res, 2016, 27 (5): 597-603.
[2]	Coelho CC. Grenho L. Gomes PS. et al. Nano-hydroxyapatite in oral care cosmetics: characterization and cytotoxicity assessment [J]. Sci Rap. 2019. 9 (1): 11-50.
[3]	Gailhre B. Uswatta S. Jayasuriya AC. Nano-scale characterization of nano-hydroxyapatite incorporated chitoson particles of bone repair [J]. Colloids Surf B Biointerfaces, 2018, 165: 158-164.
[4]	Libonati F. Nair AK. Vergani L. et al. Fracture mechanics of hydroxyapatite single crystals under geometic confinement [J]. JMech Behav Bioment Mater, 2013, 19 (7): 487-496.
[5]	de Vasconcellos LMR, do Prado RF, Sartori EM, et al. In vitroosteogenesis process induced by hybrid nanohydroxyapatite / gra-phene nanoribbons composites [J]. J Mater Sci Mater Med, 2019, 30 (7): 81.
[6]	Jain D, Sawhney A, Gupta B, et al. Clinical andradiologic eval-uation of regenerative potential of nHA paste and DBM in the treatment of periodontal intra - bony defects - A randomized con- trol trial [J]. J Clin Diagn Res, 2016, 10 (9): ZC74 - ZC79.
[7]	De Tullio I, Caputi S, Perfetti G, etal. A human clinical and histomorphometrical study on different resorbable and non -resorbable bone substitutes used in post - extractive sites. Prelim-inary Results [J]. Materials (Basel, Switzerland), 2019, 12 (15): 2408.
[8]	Zakaria SM, Sharif Zein SH, Othman MR, et al. Nanophase hydroxyapatite as a biomaterial in advanced hard tissue engineer-ing: a review [J]. Tissue Eng Part B Rev, 2013, 19 (5): 431-441.
[9]	Wang YF, Wang CY, Wan P, el al. Comparison of bone regener-alion in alveolar bone of dogs on mineralized collagen grafts with two composition ratios of nano-hydorxyapatite and colla-gen [J]. Regen Biomater, 2016, 3 (1): 33-40.
[10]	Vieira S, Vial S, Reis R L, et al. Nanoparticles for bone tissue engineering [J]. Biotechnol Prog, 2017, 33 (3): 590-611..
[11]	Liu M J, Ishida Y, Ebina Y, et al. An anisotropic hydrogel with electrostatic repulsion between cofacially aligned nanosheets [J]. Nature, 2015, 517 (7532): 68-72.
[12]	Local delivery of rhVEGF165 through biocoated nHA/coral block grafts in critical-sized dog mandible defects: a histological study at the early stages of bone healing.
[13]	Fukui N, Sato T, Kuboki Y, et al. Bone tissue reaction of nano-hydroxyapatite/collagen composite at the early stage of implanta-tion [J]. Biomed Mater Eng, 2008, 18, (1): 25-33.
[14]	Huang Z, H Sun, Lu Y, et al. Strontium/Chitosan/Hydroxyapatite/Norcantharidin Composite That Inhibits Osteosarcoma and Promotes Osteogenesis In Vitro [J]. BioMed Research International, 2020, 2020 (3): 1-9.
[15]	Zhang W, Zhou R, Yang Y, et al. Aptamer-mediated synthesis of multifunctional nano-hydroxyapatite for active tumour bioimaging and treatment. Cell Prolif. 2021; 54 (9): e13105.
[16]	Gu M, Jiang L, Hao L, et al. A novel theranostic nanoplatform for imaging-guided chemo-photothermal therapy in oral squamous cell carcinoma. J Mater Chem B. 2021; 9 (30): 6006-6016.
[17]	Park M, Sutherland JB, Rafii F. Effects of nano-hydroxyapatite on the formation of biofilms by Streptococcus mutans in two different media. Arch Oral Biol. 2019; 107: 104484.
[18]	Saredi G, Pacchetti A, et al. En Bloc Thulium Laser Enucleation of the Prostate: Surgical Technique and Advantages Compared With the Classical Technique [J]. Urology, 2017, 108: 207 - 211.
[19]	Daas I. Badr S, O sm am E. Comparison between fluoride and nano-hydroxyapatite in re-mineralizing initial enamel lesion an in vitro study [J]. Jcontermp Dentpract, 2018, 19 (3): 306-12.
[20]	Balar S, Erdem U, Doan M, et al. Dentinal tubule occluding capability of nano-hydroxyapatite; The in-vitro evaluation [J]. Microscopy Research and Technique, 2018, 81 (8): 843-54.
[21]	Motoo Niwa, Tsutomu Sato, Wei Li, et al. Polishing and whitening properties of toothpaste containing hydroxyapatite [J]. Journal of Materials Science: Materials in Medicine, 2001, 12 (3): 277-281.
[22]	Yu J, Yang HY, Li K, et al. A novel application of nanohydroxyapatite/mesoporous silica biocomposite on treating dentin hypersensitivity: an in vitro study [J]. J Dent, 2016, 50: 21-9.
[23]	Browning WD, Cho SD, Deschepper EJ. Effect of a nano-hydroxyapatite paste on bleaching-related tooth sensitivity [J]. J Esthet Restor Dent, 2012, 24 (4): 268-276.

Cite This Article

Plain Text BibTeX RIS

APA Style

Si-Yu Tao, Fei-Fei Wang, Kashaf Naz, Xue-Jing Lin, Xin-Hui Xu, et al. (2022). Nano-hydroxyapatite Use in Oral Medicine: A Review. International Journal of Materials Science and Applications, 11(3), 62-65. https://doi.org/10.11648/j.ijmsa.20221103.11

Copy | Download

ACS Style

Si-Yu Tao; Fei-Fei Wang; Kashaf Naz; Xue-Jing Lin; Xin-Hui Xu, et al. Nano-hydroxyapatite Use in Oral Medicine: A Review. Int. J. Mater. Sci. Appl. 2022, 11(3), 62-65. doi: 10.11648/j.ijmsa.20221103.11

Copy | Download

AMA Style

Si-Yu Tao, Fei-Fei Wang, Kashaf Naz, Xue-Jing Lin, Xin-Hui Xu, et al. Nano-hydroxyapatite Use in Oral Medicine: A Review. Int J Mater Sci Appl. 2022;11(3):62-65. doi: 10.11648/j.ijmsa.20221103.11

Copy | Download

@article{10.11648/j.ijmsa.20221103.11,
  author = {Si-Yu Tao and Fei-Fei Wang and Kashaf Naz and Xue-Jing Lin and Xin-Hui Xu and Yong-Chao Zhao and Xu-Cheng Hu and Bin Liu and Sheng-Ping Cao and Zhu-Ling Guo},
  title = {Nano-hydroxyapatite Use in Oral Medicine: A Review},
  journal = {International Journal of Materials Science and Applications},
  volume = {11},
  number = {3},
  pages = {62-65},
  doi = {10.11648/j.ijmsa.20221103.11},
  url = {https://doi.org/10.11648/j.ijmsa.20221103.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmsa.20221103.11},
  abstract = {Nano-hydroxyapatite (nHA) are fine particles, and its crystal structure is similar to the inorganic composition of natural bone, similar to ordinary hydroxyapatite, nHA has higher solubility biocompatibility and excellent osteogenicity, especially in repair of bone defects. In recent years, nHA as a new oral material is widely used in various fields of stomatology. The application of nano-hydroxyapatite in dental pulp, Periodontal field, maxillofacial surgery and oral health care is discussed in this paper. We describe by this article that nHA as root canal paste filling is anti-inflammatory and promote the closure of apical foramen. nHA can promote regeneration of alveolar bone cementum and periodontal membrane to form healthy periodontal tissue. nHA can also be widely used in the repair of oral bone tissue defects such as periodontal bone defect, alveolar bone reconstruction and jaw cyst. Besides, in the field of surgery, nHA can be used in defected bone area caused by surgery, it can promote bone union. In the field of oral health care, nHA can inhibit the formation of dental plaque, promote enamel remineralization, whiten teeth and relieve dentin sensitivity when applied to toothpaste, mouthwash and oral spray. The aim of this study is to provide a broad understanding of nHA and promote the use of nHA materials in the treatment of oral disease.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Nano-hydroxyapatite Use in Oral Medicine: A Review
AU  - Si-Yu Tao
AU  - Fei-Fei Wang
AU  - Kashaf Naz
AU  - Xue-Jing Lin
AU  - Xin-Hui Xu
AU  - Yong-Chao Zhao
AU  - Xu-Cheng Hu
AU  - Bin Liu
AU  - Sheng-Ping Cao
AU  - Zhu-Ling Guo
Y1  - 2022/06/14
PY  - 2022
N1  - https://doi.org/10.11648/j.ijmsa.20221103.11
DO  - 10.11648/j.ijmsa.20221103.11
T2  - International Journal of Materials Science and Applications
JF  - International Journal of Materials Science and Applications
JO  - International Journal of Materials Science and Applications
SP  - 62
EP  - 65
PB  - Science Publishing Group
SN  - 2327-2643
UR  - https://doi.org/10.11648/j.ijmsa.20221103.11
AB  - Nano-hydroxyapatite (nHA) are fine particles, and its crystal structure is similar to the inorganic composition of natural bone, similar to ordinary hydroxyapatite, nHA has higher solubility biocompatibility and excellent osteogenicity, especially in repair of bone defects. In recent years, nHA as a new oral material is widely used in various fields of stomatology. The application of nano-hydroxyapatite in dental pulp, Periodontal field, maxillofacial surgery and oral health care is discussed in this paper. We describe by this article that nHA as root canal paste filling is anti-inflammatory and promote the closure of apical foramen. nHA can promote regeneration of alveolar bone cementum and periodontal membrane to form healthy periodontal tissue. nHA can also be widely used in the repair of oral bone tissue defects such as periodontal bone defect, alveolar bone reconstruction and jaw cyst. Besides, in the field of surgery, nHA can be used in defected bone area caused by surgery, it can promote bone union. In the field of oral health care, nHA can inhibit the formation of dental plaque, promote enamel remineralization, whiten teeth and relieve dentin sensitivity when applied to toothpaste, mouthwash and oral spray. The aim of this study is to provide a broad understanding of nHA and promote the use of nHA materials in the treatment of oral disease.
VL  - 11
IS  - 3
ER  -

Copy | Download

Author Information

Si-Yu Tao

School of Dentistry, Hainan Medical University, Haikou, PR China
Fei-Fei Wang

School of Dentistry, Hainan Medical University, Haikou, PR China
Kashaf Naz

School of International Education, Hainan Medical University, Haikou, PR China
Xue-Jing Lin

School of Dentistry, Hainan Medical University, Haikou, PR China
Xin-Hui Xu

School of Dentistry, Hainan Medical University, Haikou, PR China
Yong-Chao Zhao

School of Dentistry, Hainan Medical University, Haikou, PR China
Xu-Cheng Hu

School of Dentistry, Hainan Medical University, Haikou, PR China
Bin Liu

School of Dentistry, Hainan Medical University, Haikou, PR China
Sheng-Ping Cao

School of Clinical, Hainan Medical University, Haikou, PR China
Zhu-Ling Guo

School of Dentistry, Hainan Medical University, Haikou, PR China

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Si-Yu Tao, Fei-Fei Wang, Kashaf Naz, Xue-Jing Lin, Xin-Hui Xu, et al. (2022). Nano-hydroxyapatite Use in Oral Medicine: A Review. International Journal of Materials Science and Applications, 11(3), 62-65. https://doi.org/10.11648/j.ijmsa.20221103.11

Copy | Download

ACS Style

Si-Yu Tao; Fei-Fei Wang; Kashaf Naz; Xue-Jing Lin; Xin-Hui Xu, et al. Nano-hydroxyapatite Use in Oral Medicine: A Review. Int. J. Mater. Sci. Appl. 2022, 11(3), 62-65. doi: 10.11648/j.ijmsa.20221103.11

Copy | Download

AMA Style

Si-Yu Tao, Fei-Fei Wang, Kashaf Naz, Xue-Jing Lin, Xin-Hui Xu, et al. Nano-hydroxyapatite Use in Oral Medicine: A Review. Int J Mater Sci Appl. 2022;11(3):62-65. doi: 10.11648/j.ijmsa.20221103.11

Copy | Download

@article{10.11648/j.ijmsa.20221103.11,
  author = {Si-Yu Tao and Fei-Fei Wang and Kashaf Naz and Xue-Jing Lin and Xin-Hui Xu and Yong-Chao Zhao and Xu-Cheng Hu and Bin Liu and Sheng-Ping Cao and Zhu-Ling Guo},
  title = {Nano-hydroxyapatite Use in Oral Medicine: A Review},
  journal = {International Journal of Materials Science and Applications},
  volume = {11},
  number = {3},
  pages = {62-65},
  doi = {10.11648/j.ijmsa.20221103.11},
  url = {https://doi.org/10.11648/j.ijmsa.20221103.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmsa.20221103.11},
  abstract = {Nano-hydroxyapatite (nHA) are fine particles, and its crystal structure is similar to the inorganic composition of natural bone, similar to ordinary hydroxyapatite, nHA has higher solubility biocompatibility and excellent osteogenicity, especially in repair of bone defects. In recent years, nHA as a new oral material is widely used in various fields of stomatology. The application of nano-hydroxyapatite in dental pulp, Periodontal field, maxillofacial surgery and oral health care is discussed in this paper. We describe by this article that nHA as root canal paste filling is anti-inflammatory and promote the closure of apical foramen. nHA can promote regeneration of alveolar bone cementum and periodontal membrane to form healthy periodontal tissue. nHA can also be widely used in the repair of oral bone tissue defects such as periodontal bone defect, alveolar bone reconstruction and jaw cyst. Besides, in the field of surgery, nHA can be used in defected bone area caused by surgery, it can promote bone union. In the field of oral health care, nHA can inhibit the formation of dental plaque, promote enamel remineralization, whiten teeth and relieve dentin sensitivity when applied to toothpaste, mouthwash and oral spray. The aim of this study is to provide a broad understanding of nHA and promote the use of nHA materials in the treatment of oral disease.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Nano-hydroxyapatite Use in Oral Medicine: A Review
AU  - Si-Yu Tao
AU  - Fei-Fei Wang
AU  - Kashaf Naz
AU  - Xue-Jing Lin
AU  - Xin-Hui Xu
AU  - Yong-Chao Zhao
AU  - Xu-Cheng Hu
AU  - Bin Liu
AU  - Sheng-Ping Cao
AU  - Zhu-Ling Guo
Y1  - 2022/06/14
PY  - 2022
N1  - https://doi.org/10.11648/j.ijmsa.20221103.11
DO  - 10.11648/j.ijmsa.20221103.11
T2  - International Journal of Materials Science and Applications
JF  - International Journal of Materials Science and Applications
JO  - International Journal of Materials Science and Applications
SP  - 62
EP  - 65
PB  - Science Publishing Group
SN  - 2327-2643
UR  - https://doi.org/10.11648/j.ijmsa.20221103.11
AB  - Nano-hydroxyapatite (nHA) are fine particles, and its crystal structure is similar to the inorganic composition of natural bone, similar to ordinary hydroxyapatite, nHA has higher solubility biocompatibility and excellent osteogenicity, especially in repair of bone defects. In recent years, nHA as a new oral material is widely used in various fields of stomatology. The application of nano-hydroxyapatite in dental pulp, Periodontal field, maxillofacial surgery and oral health care is discussed in this paper. We describe by this article that nHA as root canal paste filling is anti-inflammatory and promote the closure of apical foramen. nHA can promote regeneration of alveolar bone cementum and periodontal membrane to form healthy periodontal tissue. nHA can also be widely used in the repair of oral bone tissue defects such as periodontal bone defect, alveolar bone reconstruction and jaw cyst. Besides, in the field of surgery, nHA can be used in defected bone area caused by surgery, it can promote bone union. In the field of oral health care, nHA can inhibit the formation of dental plaque, promote enamel remineralization, whiten teeth and relieve dentin sensitivity when applied to toothpaste, mouthwash and oral spray. The aim of this study is to provide a broad understanding of nHA and promote the use of nHA materials in the treatment of oral disease.
VL  - 11
IS  - 3
ER  -

Copy | Download