Polarography is widely used to determine diverse organic and inorganic depolarizers present at micro- to ultra-micro levels. Accordingly, experimental sets were prepared by maintaining the overall concentrations of metal ion and supporting electrolyte (ammonium tartrate) constant at 1.0 mM and 1.0 M, respectively. Coumarin and its complexes showed well-defined cathodic reduction waves at pH 8.2 ± 0.02 in a 0.2 M ammonium tartrate medium. The plots of id vs √hcorr showed a linear relationship and passed through the origin in all cases, indicating that the electrode reduction process was diffusion-controlled. Polarographic measurements showed that increasing the ligand concentration shifted the half-wave potential to more negative values. The plot of change in half wave potential with logarithm of change in ligand concentration yielded a straight line, demonstrating the formation of a single complex species for the Co(II)-coumarin system. A comparison between the infrared spectra of the free drug and its Co(II) complex showed the disappearance of the carbonyl (C=O) band at 1725 cm-1. Additionally, the sharp -OH band observed at 3570 cm-1 in free coumarin shifted to 3600 cm-1 in the Co(II)-coumarin complex. The anticoagulant activity of the normal control and the respective test drug samples was evaluated, and the results are presented in the respective tables. The mean prothrombin times obtained for coumarin and its complexes are illustrated clearly in this research article. Polarography is widely utilized for the determination of diverse organic and inorganic depolarizers present at micro- to ultra-trace levels in analytical samples.
| Published in | World Journal of Applied Chemistry (Volume 11, Issue 4) |
| DOI | 10.11648/j.wjac.20261104.12 |
| Page(s) | 114-120 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2026. Published by Science Publishing Group |
Coumarin, Metal Complex, Ammonium Tartrate, Polarography, In-Vitro Study, Pharmacology
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APA Style
Choure, R., Choure, N., Samim, S. A. (2026). Bioelectrochemical and Pharmacological Study of Co-Coumarin Complex. World Journal of Applied Chemistry, 11(4), 114-120. https://doi.org/10.11648/j.wjac.20261104.12
ACS Style
Choure, R.; Choure, N.; Samim, S. A. Bioelectrochemical and Pharmacological Study of Co-Coumarin Complex. World J. Appl. Chem. 2026, 11(4), 114-120. doi: 10.11648/j.wjac.20261104.12
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Download@article{10.11648/j.wjac.20261104.12,
author = {Rakesh Choure and Neelam Choure and SK Abdus Samim},
title = {Bioelectrochemical and Pharmacological Study of
Co-Coumarin Complex},
journal = {World Journal of Applied Chemistry},
volume = {11},
number = {4},
pages = {114-120},
doi = {10.11648/j.wjac.20261104.12},
url = {https://doi.org/10.11648/j.wjac.20261104.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjac.20261104.12},
abstract = {Polarography is widely used to determine diverse organic and inorganic depolarizers present at micro- to ultra-micro levels. Accordingly, experimental sets were prepared by maintaining the overall concentrations of metal ion and supporting electrolyte (ammonium tartrate) constant at 1.0 mM and 1.0 M, respectively. Coumarin and its complexes showed well-defined cathodic reduction waves at pH 8.2 ± 0.02 in a 0.2 M ammonium tartrate medium. The plots of id vs √hcorr showed a linear relationship and passed through the origin in all cases, indicating that the electrode reduction process was diffusion-controlled. Polarographic measurements showed that increasing the ligand concentration shifted the half-wave potential to more negative values. The plot of change in half wave potential with logarithm of change in ligand concentration yielded a straight line, demonstrating the formation of a single complex species for the Co(II)-coumarin system. A comparison between the infrared spectra of the free drug and its Co(II) complex showed the disappearance of the carbonyl (C=O) band at 1725 cm-1. Additionally, the sharp -OH band observed at 3570 cm-1 in free coumarin shifted to 3600 cm-1 in the Co(II)-coumarin complex. The anticoagulant activity of the normal control and the respective test drug samples was evaluated, and the results are presented in the respective tables. The mean prothrombin times obtained for coumarin and its complexes are illustrated clearly in this research article. Polarography is widely utilized for the determination of diverse organic and inorganic depolarizers present at micro- to ultra-trace levels in analytical samples.},
year = {2026}
}
TY - JOUR T1 - Bioelectrochemical and Pharmacological Study of Co-Coumarin Complex AU - Rakesh Choure AU - Neelam Choure AU - SK Abdus Samim Y1 - 2026/11/11 PY - 2026 N1 - https://doi.org/10.11648/j.wjac.20261104.12 DO - 10.11648/j.wjac.20261104.12 T2 - World Journal of Applied Chemistry JF - World Journal of Applied Chemistry JO - World Journal of Applied Chemistry SP - 114 EP - 120 PB - Science Publishing Group SN - 2637-5982 UR - https://doi.org/10.11648/j.wjac.20261104.12 AB - Polarography is widely used to determine diverse organic and inorganic depolarizers present at micro- to ultra-micro levels. Accordingly, experimental sets were prepared by maintaining the overall concentrations of metal ion and supporting electrolyte (ammonium tartrate) constant at 1.0 mM and 1.0 M, respectively. Coumarin and its complexes showed well-defined cathodic reduction waves at pH 8.2 ± 0.02 in a 0.2 M ammonium tartrate medium. The plots of id vs √hcorr showed a linear relationship and passed through the origin in all cases, indicating that the electrode reduction process was diffusion-controlled. Polarographic measurements showed that increasing the ligand concentration shifted the half-wave potential to more negative values. The plot of change in half wave potential with logarithm of change in ligand concentration yielded a straight line, demonstrating the formation of a single complex species for the Co(II)-coumarin system. A comparison between the infrared spectra of the free drug and its Co(II) complex showed the disappearance of the carbonyl (C=O) band at 1725 cm-1. Additionally, the sharp -OH band observed at 3570 cm-1 in free coumarin shifted to 3600 cm-1 in the Co(II)-coumarin complex. The anticoagulant activity of the normal control and the respective test drug samples was evaluated, and the results are presented in the respective tables. The mean prothrombin times obtained for coumarin and its complexes are illustrated clearly in this research article. Polarography is widely utilized for the determination of diverse organic and inorganic depolarizers present at micro- to ultra-trace levels in analytical samples. VL - 11 IS - 4 ER -
Assistant Professor Department of Chemistry, PMCoE Government JST PG College, Balaghat M. P, India
Assistant Professor Department of Chemistry, PMCoE Government JST PG College, Balaghat M. P, India
Assistant Professor Department of Chemistry, Veerangna Rani Avaintibai Government College Khairlanji, Balaghat M. P, India
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