American Journal of Bioscience and Bioengineering

Special Issue

Stem Cells for Neuro-Regeneration: Where Do We Stand

  • Submission Deadline: Jun. 30, 2015
  • Status: Submission Closed
  • Lead Guest Editor: Venkata Atluri
About This Special Issue
This issue will try to cover the state-of-the art in the subject of neuroregeneration through stem cell therapy. It will try to cover basic neuroscience as well as clinical trials in the field. Clinical applications will encompass traumatic, degenerative, and genetic central and peripheral nervous system disorders. The proposed sections of the issue will be:

1. In-vitro differentiation of various stem cell types into neural lineage
2. Mechanisms of neuroregeneration
3. In-vitro differentiation versus undifferentiated stem cell therapy
4. Evaluation of neural regeneration: steps towards standardization
5. Clinical trials in stem cell therapy in spinal cord injuries
6. Clinical trials in cerebral palsy
7. Clinical trials in cerebral stroke
8. Clinical trials in Parkinsonism
9. Clinical trials in Alzhiemer's disease
10. Clinical trials in ALS
11. Clinical trials in MS
12. The role of IPS in neural regeneration
Lead Guest Editor
  • Venkata Atluri

    Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, United States

Guest Editors
  • xiang cheng

    Department of Radiation Oncology, Ohio State University, Columbus, United States

  • Wael Abo El-Kheir

    Immunology, Military Medical Academy, Cairo, Egypt

  • Hala Gabr

    Clinical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

  • Mehdi Jorfi

    Massachusetts Institute of Technology (MIT), Cambridge, United States

  • Maheedhar Kodali

    Iinstitute of Regenerative Medicine, Texas A&M Health Science Center, College of Medicine, United States

  • vilas wagh

    Harvard Medical School, United States

  • Gautam Bedadala

    Bayer, United States

  • Iana Katz

    Department of Immunology, Pasteur Institute, São Paulo, Brazil

  • Dr Sonia Saraswat

    Physiology Reproduction and Shelter Management Division, Central Institute for Research on Goats, Mathura, India

  • Rasoul Rajaei

    Laboratory of Systems Biology and Bioinformatics (LBB), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran

  • Senbiao Fang

    National institute of biological sciences (Beijing), Beijing, China

Published Articles
  • Stem Cells for Neuro-regeneration: State of the Art

    Wagih A. , Elhawary S. , Ellessy R. M. , Esam B. , Tarek I. , Aamer M.

    Issue: Volume 3, Issue 4-1, July 2015
    Pages: 56-70
    Received: Jun. 09, 2015
    Accepted: Jun. 17, 2015
    Published: Jul. 09, 2015
    DOI: 10.11648/j.bio.s.2015030401.19
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    Abstract: Neuroregeneration (NR) is a long-sought medical dream which has intrigued vast research in the past decades. A traditional physiologic dogma that central nervous system does not regenerate has been strongly challenged in the recent years since the advent of the stem cell era. Stem cell research in the regenerative field passes through three main st... Show More
  • Neurogenic Differentiation of Bone Marrow-derived Mesenchymal Stem Cells Using Neural Induction Medium: A Morphological and Histochemical Study

    Ahmedy E. , Kandel S. , Gabr H. , Rizk S. , Khalifa . K , Kamal S.

    Issue: Volume 3, Issue 4-1, July 2015
    Pages: 43-50
    Received: Jun. 26, 2015
    Accepted: Jun. 27, 2015
    Published: Jul. 06, 2015
    DOI: 10.11648/j.bio.s.2015030401.17
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    Abstract: Background: Mesenchymal stem cells (MSCs) are multipotent adult stem cells present in all tissues. They are present in bone marrow, and can differentiate in vitro into neurons, glial cells and myofibroblasts . MSCs have been proposed as sources of stem cells for regeneration of the CNS. Thus, one of the goals of regenerative medicine is to regenera... Show More
  • In Vitro Differentiation of Human Bone Marrow Stem Cells into Retinal Pigment Epithelium

    Nehal Draz , Makram F. Attalah , Hany M. Shaheen , Wael Abo Elkeir

    Issue: Volume 3, Issue 4-1, July 2015
    Pages: 51-55
    Received: Jun. 26, 2015
    Accepted: Jun. 27, 2015
    Published: Jul. 06, 2015
    DOI: 10.11648/j.bio.s.2015030401.18
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    Abstract: Introduction: Dysfunction, degeneration, and loss of retinal pigment epithelial (RPE) cells are prominent features of subtypes of retinitis pigmentosa (RP) which is a cause of visual disability. In this condition, there is progressive visual loss that often leads to blindness. A variety of therapeutic approaches to delay the degenerative process ar... Show More
  • Stem Cell Transplantation for Traumatic Spinal Cord Injury: What Have We Learned from Previous Experience

    Elhawary S. , Wagih A. , Essam B. , Tarek I. , Aamer M. , Ellessy R. M.

    Issue: Volume 3, Issue 4-1, July 2015
    Pages: 34-42
    Received: Jun. 20, 2015
    Accepted: Jun. 22, 2015
    Published: Jul. 06, 2015
    DOI: 10.11648/j.bio.s.2015030401.16
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    Abstract: Spinal cord injuries represent one of the most devastating illnesses that can affect the human body. Before the advent of the regenerative medicine era, it was regarded as an untreatable condition. Stem cell plasticity and translational medicine research open a new window of hope for this category of patients. Clinical trials of stem cell therapy f... Show More
  • Allogenic Mesenchymal Stromal Cell Therapy for Type III Spinal Muscular Atrophy: Case Report

    Abo Elkheir W. , Gabr H. , Salah Y.

    Issue: Volume 3, Issue 4-1, July 2015
    Pages: 30-33
    Received: Jun. 09, 2015
    Accepted: Jun. 10, 2015
    Published: Jun. 30, 2015
    DOI: 10.11648/j.bio.s.2015030401.15
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    Abstract: Rationale : Spinal Muscular Atrophy (SMA) is the most common genetic disorder and presents the most common cause of infant mortality. To date, patient management is symptomatic and focuses on improvement of independence and treatment of complications. Stem cell therapy represents a novel therapeutic option for many neurological diseases. Presenting... Show More
  • Intrathecal Autologous Bone Marrow Derived MSC Therapy in Cerebral Palsy: Safety and Short Term Efficacy

    Hala Gabr , Wael Abou El-Kheir , Osama Ghannam , Mohamed Esewy El-Fiki , Yehia Salah

    Issue: Volume 3, Issue 4-1, July 2015
    Pages: 24-29
    Received: May 29, 2015
    Accepted: Jun. 01, 2015
    Published: Jun. 30, 2015
    DOI: 10.11648/j.bio.s.2015030401.14
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    Abstract: Objectives: Cerebral palsy (CP) is a disorder caused by injury or abnormal development of the brain at or immediately after birth. Current management of CP may improve the symptoms, such as muscle tone and gait, but is not directed to the original damage. Cellular therapy is evolving as a regenerative tool in many diseases with neural damage. Mesen... Show More
  • The Role of Adipose Derived Mesenchymal Stem Cells in Enhancement of Peripheral Nerve Injuries Repair

    Ayad H. , Zahra M. , Gabr H. , Ismaeil A. , Abo Elkheir Y.

    Issue: Volume 3, Issue 4-1, July 2015
    Pages: 18-23
    Received: May 29, 2015
    Accepted: Jun. 01, 2015
    Published: Jun. 30, 2015
    DOI: 10.11648/j.bio.s.2015030401.13
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    Abstract: Background: About 50% of peripheral nerve injuries leave permenant disability. Trials to enhance nerve repair using stem cells are undergoing. Adipose derived mesenchymal stem cells (ADSCs) are good candidates for cellular-induced regeneration. Aim of the Work: The aim of the present work is to evaluate the effect of ADSCs on enhancing repair of pe... Show More
  • Two-Step Induction of Dopaminergic Neurone Differentiation of Leukapharesis-Derived Mesenchymal Stem Cells

    Zeinab M. Ismail , Menna M. Abdel-Dayem , Nagla M. Salama , Hala Gabr , Dalia I. Ismail , Ahmed S. Abdelhafiz , Shaimaa I. El-Jaafary

    Issue: Volume 3, Issue 4-1, July 2015
    Pages: 7-17
    Received: Apr. 09, 2015
    Accepted: Apr. 09, 2015
    Published: May 06, 2015
    DOI: 10.11648/j.bio.s.2015030401.12
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    Abstract: Background: Neurodegenerative diseases represent a great medical challenge with marked consequences on quality of life of the patients and their families. Parkinson's disease (PD) constitutes a relatively common neurodegenerative disorder characterized by defect in dopaminergic neurons. The regenerative effect of mesenchymal stem cells (MSCs) stimu... Show More
  • Intrathecal Autologous Bone Marrow Derived Mesenchymal Stem Cells for Ischemic Stroke: Short Term Safety and Efficacy Study

    Abo Elkheir W , Reda M. A. , Montaser I. A. , Salem A. E. , Sakr M. A.

    Issue: Volume 3, Issue 4-1, July 2015
    Pages: 1-6
    Received: Apr. 01, 2015
    Accepted: Apr. 02, 2015
    Published: May 06, 2015
    DOI: 10.11648/j.bio.s.2015030401.11
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    Abstract: Background: Preclinical and animal studies provide considerable hope for stem cell therapy in cerebrovascular stroke. This study was designed as a pilot study to explore this provisional data. Autologous bone marrow derived mesenchymal stem cells were chosen due to their proven angiogenic, paracrine and neuroregenerative functions. Subjects and Met... Show More