American Journal of Biomedical and Life Sciences

Special Issue

Mechanisms of Protection Against Oxidative Stress

  • Submission Deadline: 20 December 2014
  • Status: Submission Closed
  • Lead Guest Editor: Vadim Davydov
About This Special Issue
Oxidative stress arises in living organisms when pro-oxidant and antioxidant systems are imbalanced. It can be associated with different physiological states (fasting, physical activity, aging, etc.) and pathological processes (diseases of cardiovascular, central nervous and endocrine, respiratory system, etc.). All these diseases and physiological processes are accompanied by formation of stress in the organism. Stress is followed by stimulation of sympathetic adrenal system which causes increase of epinephrine secretion and formation of tissue hypoxia phenomena. As a consequence, the generation of free radicals in cells enhances and chain free radical processes initiate. Increasing of the free radicals level causes damage of cell components.

Oxidative stress is one of the central nonspecific components of pathogenesis of visceral diseases. Therefore, correction of its manifestations can use as non-specific approach to their treatment and prevention. The use of antioxidants nowadays becomes traditional in protecting against oxidative stress. However, the initial hopes for the effectiveness of their use for this purpose have largely failed to materialize. The use of inefficient natural and synthetic antioxidants, as well as their use in inadequate doses may be the reason for this. In this context, it seems more appropriate to increase production of native antioxidants in the organism, primarily enzymes of first line of antioxidant defense for protection against oxidative stress.

Considering the possibility of antioxidants application for protection against oxidative stress, it is necessary to pay attention to the fact that oxidative stress plays an important role in the cells adaptation to free radical damage. This effect is implemented through the stimulation of intracellular signaling pathways associated with the synthesis of antioxidant enzymes and heat shock proteins by reactive oxygen species. Therefore the suppression of this process is not justified. K. Uchida (2000) considers carbonyl products of free radical oxidation as the damaging messengers of oxidative stress.

In this regard, limitation of the negative effect of intensively generated aldehydes during stress can be considered as a fundamentally different approach to protecting against oxidative stress. For this purpose, aldehyde scavengers can be used as well as methods for increasing the rate of gene expression of enzymes catalyzing aldehyde catabolism.

Taking into account the practical importance of searching for new effective approaches to the protection from negative manifestations of oxidative stress in the development of new methods for treatment and prevention of stress-induced diseases, we dedicate a special issue of the journal to this problem.
Lead Guest Editor
  • Vadim Davydov

    Department of Biochemistry, State Budgetary Educational Institution of Higher Professional Education “Ryazan State I. P. Pavlov Medical University” of Ministry of Public Health of Russian Federation, Ryazan, Russian Federation

Guest Editors
  • Soumyabrata Munshi

    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, United States

  • Anatoly Bozhkov

    Biology Research Institute of Karazin, Kharkov National University, Kharkov, Ukraine

  • Karolina Siwicka

    Medical University of Gdansk, Department of Medical Chemistry, Poland

  • Jing Zhang

    Frontier Institute of Science and Techonogy, Xi'an Jiaotong University, China

Published Articles
  • Interconnection of Antitoxic and Antioxidant Systems of the Organism under the Action of Natural Low Molecular Complex – Fungidol

    Natalia Igorevna Kurguzova , Anatoliy Ivanovich Bozhkov , Yuriy Viktorovich Nikitchenko , Mohammad Ali Yousef Al Begai , Anatoliy Vladimirovich Goltvyansky , Mohammad Morshed Ayed Alsardia , Andrew Anatolievich Bozhkov

    Issue: Volume 2, Issue 6-1, December 2014
    Pages: 25-32
    Received: 23 December 2014
    Accepted: 10 January 2015
    Published: 23 January 2015
    DOI: 10.11648/j.ajbls.s.2014020601.15
    Abstract: The influence of the natural complex of low molecular weight compounds (fungidol) on antitoxic and antioxidant systems in animals was investigated. It was demonstrated that the introduction to the experimental animals of fungidol in doses a 0.05 ml per 100 g of body weight increases antioxidant enzymes activity in serum and liver, decreases the con... Show More
  • Differences in the System of Nitrogen Synthesis and Content of Metabolites in Antioxidant Systems of Sportsmen of Different Sex

    Nadezhda V. Bogdanovskaya , Anastasia V. Golubenko

    Issue: Volume 2, Issue 6-1, December 2014
    Pages: 19-24
    Received: 28 October 2014
    Accepted: 29 November 2014
    Published: 27 December 2014
    DOI: 10.11648/j.ajbls.s.2014020601.14
    Abstract: The research has been conducted on 26 high qualification sportsmen of different sex, adapted to perform protracted physical activity of high intensity. Determined is the presence of gender differences in oxidizing and no oxidizing metabolism of L-arginine, including also the system of nitrogen oxide synthesis (oxidizing de novo and no oxidizing reu... Show More
  • Morphological and Functional Positive Effect with the Association of Hyperbaric Oxygen Therapy and Corticoid Against Acute Acoustic Trauma

    Gleice Cristina Colombari , Adriana de Andrade Batista Murashima , Omar Feres , Miguel Angelo Hyppolito

    Issue: Volume 2, Issue 6-1, December 2014
    Pages: 13-18
    Received: 29 October 2014
    Accepted: 19 November 2014
    Published: 29 November 2014
    DOI: 10.11648/j.ajbls.s.2014020601.13
    Abstract: Studies describe the use of corticosteroids as the best alternative to treat acoustic trauma, but recent studies point to their combination with hyperbaric oxygen therapy (HBOT) as the major benefit in lesions by noise. This study aimed to evaluate the association between HBOT and corticoid therapy (CT). Female guinea pigs were exposed to a white n... Show More
  • Stem Cells Take Part in Regulation of Prooxidant Activity and Immunity at Liver Fibrosis

    Anatoliy Ivanovich Bozhkov , Elena Mikhajlovna Klimova , Yuriy Viktorovich Nikitchenko , Vadim Vyacheslavovich Davydov , Oxana Vladimirovna Zvyagintseva , Natalia Igorevna Kurguzova , Vadim Ivanovich Sidorov , Alexandr Vladimirovich Naglov

    Issue: Volume 2, Issue 6-1, December 2014
    Pages: 5-12
    Received: 13 October 2014
    Accepted: 20 November 2014
    Published: 26 November 2014
    DOI: 10.11648/j.ajbls.s.2014020601.12
    Abstract: It has been explored the possibility of correction of prooxidant-antioxidant parameters at rats with experimental liver fibrosis and immunological status of these animals using xenogeneic embryonic stem cells. It is shown that the threefold sequential administration of copper sulfate in dose 1 mg / 100 g of body weight, which amounted to 30% of the... Show More
  • Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats

    Vadim Vyacheslavovich Davydov , Anatoliy Ivanovich Bozhkov , Evgeniya Romanovna Grabovetskaya

    Issue: Volume 2, Issue 6-1, December 2014
    Pages: 1-4
    Received: 3 August 2014
    Accepted: 6 August 2014
    Published: 13 August 2014
    DOI: 10.11648/j.ajbls.s.2014020601.11
    Abstract: Resistance of the organism to the stress injury changes during ontogenesis. In this regard, the incidence of cardiovascular, central nervous, endocrine systems, etc. increases at certain stages of individual development. Taking into account the fact that the development of stress-caused lesions is associated with accumulation of carbonyl products o... Show More