,
Biruktawit Abdu,
Selamawit Fentahun,
Samrawit Girma,
Isael Genobaye,
Ejigayehu Demssie
Antimicrobial resistance (AMR) has emerged as one of the most pressing global health threats of the 21st century, jeopardizing the effective treatment of infectious diseases across humans, animals, and the environment. In livestock production, antimicrobials are widely used for therapeutic, prophylactic, and growth-promoting purposes. Therefore, the objective of this review is to examine the application of One Health approaches in addressing AMR in livestock and to identify key challenges and opportunities for their effective implementation. The inappropriate and excessive use of antimicrobials in animals has accelerated the emergence and spread of resistant pathogens. These resistant bacteria can be transmitted to humans through direct contact, food consumption, and environmental contamination, posing significant risks to public health, food security, and economic stability. Addressing AMR from a single-sector perspective has proven inadequate. A One Health approach which recognizes the interdependence of human, animal, and environmental health offers a more sustainable and effective solution. Despite growing global and national advocacy for One Health strategies, implementation remains inconsistent, particularly in the livestock sector. In many low- and middle-income countries, antimicrobial use in animals is poorly regulated, data on usage and resistance patterns are limited, and cross-sectoral collaboration is weak. Although One Health frameworks exist, their operationalization in livestock systems is hindered by gaps in policy, coordination, and technical capacity. In conclusion, AMR in livestock is a complex issue that requires a collaborative, multisectoral response. Strengthening the One Health approach is essential to tackle AMR at its source. As a key recommendation, countries should establish a national One Health coordination platform that brings together stakeholders from human, animal, and environmental health sectors to implement harmonized surveillance, promote responsible antimicrobial use, and support education and capacity building. Strong political commitment and sustained investment are crucial for achieving long-term impact.
| Published in | American Journal of Zoology (Volume 8, Issue 4) |
| DOI | 10.11648/j.ajz.20250804.12 |
| Page(s) | 85-92 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2025. Published by Science Publishing Group |
Antimicrobial Resistance, Microorganisms, One Health
| [1] | Barlam, T. F., Cosgrove, S. E., Abbo, L. M., Macias-Hoag, B. J., Cabral, L., Maragakis, L and Saint, S. (2016); implementing an antibiotic stewardship program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clinical Infectious Diseases, 62(10): 51-77. |
| [2] | Bartlett, J. G., Gilbert, D. N. and Spellberg, B. (2013): Seven ways to preserve the miracle of antibiotics. Clinical Infectious Diseases, 56(10), 1445–1450. |
| [3] | Berendonk, T. U., Manaia, C. M., Merlin, C., Fatta-Kassinos, D., Cytryn, E., Walsh, F. and Schwartz, T. (2015); tackling antibiotic resistance: the environmental framework. Nature Reviews Microbiology, 13(5): 310-317. |
| [4] | Centers for Disease Control and Prevention (CDC). One Health Basics. CDC: 2022. |
| [5] | Chowdhury R, Haque M, Islam K, Khaleduzzaman. (2009): antibiotics in an animal feed. Bangladesh J. Anim. Sci. 38(1-2): 22–33. |
| [6] | Davey, P., Brown, E., Fenelon, L., Finn, G., Gray, A., Scott, C. L. and Nathwani, D. (2017); Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database of Systematic Reviews (2). |
| [7] | Dharan, S. and Pittet, D. (2005): Environmental Contamination. Infection Control and Hospital Epidemiology, 26(3): 245-247. |
| [8] | Dhillon, R. H. P. and Clark, J. (2012): Controlling antimicrobial resistance in low- and middle-income countries. BMJ, 344: 1567. |
| [9] | European Commission. (2017): A European One Health Action Plan against Antimicrobial Resistance (AMR). EC. |
| [10] |
FAO. (2020): The FAO Action Plan on Antimicrobial Resistance 2021–2025.
https://www.fao.org/antimicrobial-resistance/resources/publications/en/ |
| [11] | Fonkwo, P. N. (2008): Pricing infectious disease: The economic and health implications of infectious diseases. EMBO Reports, 9(1): S13–S17. |
| [12] | Grace D. (2015): Review of evidence on antimicrobial resistance and animal agriculture in developing countries. International Livestock Research Institute (ILRI). |
| [13] | Guglielmi, G. (2017): Superbugs threaten to return us to the pre-antibiotic era. Nature, 543(7643): 15. |
| [14] | Hassan M. M, Amin K. B, Ahaduzzaman M, Alam M, Faruk M. S, Uddin I.(2014): Antimicrobial resistance pattern against E. coli and Salmonella in layer poultry. Res. J. Vet. Pract. 12(2): 30–35. |
| [15] | Kappes, A., Tozooneyi, T., Shakil, G., Railey, A. F., McIntyre, K. M., Mayberry, D. E., Rushton, J., Pendell, D. L. and Marsh, T. L., (2023): Livestock health and disease economics: a scoping review of selected literature. Frontiers in Veterinary Science, 10, Article 1168649. |
| [16] | Karam, G., Chastre, J., Wilcox, M. H. and Vincent, J. L., 2016: Antibioticstrategiesintheeraofmultidrugresistance. CriticalCare, 20(1): pp. 1-9. |
| [17] | Landers, T. (2012): A Review of Antibiotic Use in Food Animals: Perspective, Policy, and Potential. Public Health Reports, 127(1): 4–22. |
| [18] | Larsson, D. J. and Flach, C. F., 2022: Antibiotic resistance in the environment. |
| [19] | Laxminarayan, R., Brown, G. M. and Smith, D. L., 2001: Evaluating the economic impact of antimicrobial resistance: model and application. Journal of HealthEconomics, 20(6): pp. 899–917. |
| [20] | Marti E, Variatza E, Balcazar JL (2014): The role of aquatic ecosystems as reservoirs of antibiotic resistance. Trends in Microbiology, 22(1), pp. 36–41. |
| [21] | McEwen, S. A., & Collignon, P. J. (2018): Antimicrobial resistance: A One Health perspective. In F. M. Aarestrup (Ed.), Antimicrobialresistance in bacteria from livestock and companion animals (pp. 521–547). American Society for Microbiology Press. |
| [22] | McNerney, R. (2015): Diagnostics for developing countries. Diagnostics, 5(2): 200–209. |
| [23] | Oloso N. O, Fagbo S, Garbati M, Olonitola S. O, Awosanya E. J, Aworh M. K, Adamu H, Odetokun I. A, Fasina F. O. (2018): Antimicrobial resistance in food animals and the environment in Nigeria: A review. Int. J. Environ. Res. Public Health, 15(6): 1284. |
| [24] | O'Neill J.(2016): Tackling drug-resistant infections globally: Final report and recommendations the review on antimicrobial resistance,: 10–84. |
| [25] | O'Neill, J. (2018). Tackling drug-resistant infections globally: final report and recommendations. Ongoing efforts to improve antimicrobial utilization in hospitals among African countries and implications for the future. Antibiotics, 11(12), 1824. |
| [26] | Othieno, E., Okalebo, F., Guantai, A., and Opanga, S., 2020: Assessment of knowledge, attitudes, and practices about antibiotic resistance among medical students in Kenya. Journal of Pharmaceutical Policy and Practice, 13, pp. 1–7. |
| [27] | Pittet, D., Mourouga, P. and Perneger, T. V. (2000): Compliance with handwashing in a teaching hospital. *Annals of Internal Medicine, 130(2): 126-130. |
| [28] | Pruden, A., Larsson, D. G., Amézquita, A., Collignon, P., Brandt, K. K., Graham, D. W. and Li, B. (2013): Human health risk assessment of antibiotic resistance in the environment: state of the science and knowledge gaps. Environmental Health Perspectives, 121(9): 1066-1075. |
| [29] | Reygaert, W. C., 2018: An overview of the antimicrobial resistance mechanisms of bacteria. AIMS Microbiology, 4(3), pp. 482–501. |
| [30] | Ruiz-Ramos, J. and Ramírez, P. 2022: antimicrobial stewardship programs in the Intensive Care Unit in patients with infections caused by multi drug resistant Gram-negative bacilli. Medicinal intensively (English Edition). |
| [31] | Saleem, Z., Godman, B., Cook, A., Khan, M. A., Campbell, S. M., Seaton, R. A., Siachalinga, L., Haseeb, A., Amir, A., Kurdi, A. and Mwita, J. C., (2022): Ongoing efforts to improve antimicrobial utilization in hospital are among African countries and implications for the future. Antibiotics, 11(12): p. 1824. |
| [32] | Shamsuddin M, Alam M, Hossein M, Goodger W, Bari F, Ahmed T, Hossain M, Khan A. (2007): Participatory rural appraisal to identify needs and prospects of market-oriented dairy industries in Bangladesh. Trop. Anim. Health Prod, 39(8): 567 |
| [33] | Shrestha, P., Cooper, B. S., Coast, J., Oppong, R., Do Thi Thuy, N., Phodha, T., Celhay, O., Guerin, P. J., Wertheim, H. and Lubell, Y., 2018. Enumerating the economic cost of antimicrobial resistance per antibiotic consumed to inform the evaluation of interventions affecting their use. Antimicrobial Resistance and Infection Control, 7, pp. 1-9. |
| [34] | Thornton PK. 2010: Livestock production: recent trends, future prospects. Philos Trans R SocLond B Biol Sci.; 365(1554): 2853–2867. |
| [35] | Van Boeckel, T. P., et al. (2015): Global trends in antimicrobial use in food animals. PNAS, 112(18): 5649–5654. |
| [36] | Velazquez-meza, M. E., Galarde-lopez, M., carrillo-quiroz, B. and Alpuche- Aranda, C. M,. (2022): antimicrobial resistance one health approach. veternary word, 15(3): p 743. |
| [37] | Ventola, C. L. (2015): The antibiotic resistance crisis: part 1: causes and threats. Pharmacy and Therapeutics, 40(4): 277–283. |
| [38] | Wall, B. A., Mateus, A. L. P., Marshall, L., Pfeiffer, D. U., Lubroth, J., Ormel, H. J., Otto, P. and Patriarchi, A. (2016): Drivers, dynamics and epidemiology of antimicrobial resistance in animal production. Food and Agriculture Organization of the United Nations. |
| [39] | Wemette, M., Safi, A. G., Beauvais, W., Ceres, K., Shapiro, M., Moroni, P., Welcome, F. L. and Ivanek, R. (2020): New York State dairy farmers’ perceptions of antibiotic use and resistance: A qualitative interview study. PLOS ONE, 15(5): e0232937. |
| [40] | Wertheim, H. F. L., Chandna, A., & Vu, P. D. (2010): Providing evidence to support practical strategies for controlling antimicrobial resistance. Jou Anti Chemoth, 65(8): 1741–1743. |
| [41] | WHO (2017): Guidelines on Use of Medically Important Antimicrobials in Food-Producing Animals. |
| [42] |
WHO (2020): Antimicrobial resistance.
https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance |
| [43] |
WHO, FAO, OIE and UNEP (2022): Strategic framework for collaboration on antimicrobial resistance – together for One Health. Geneva: World Health Organization. Available at:
https://www.who.int/publications-detail-redirect/9789240045408 (Accessed: March 12, 2024). |
| [44] | Ziping W. (2018): Antimicrobial use in food animal production: Situation analysis and contributing factors. Front. Agric. Sci. Eng, 5(3): 301–311. |
| [45] | Vanden Honert, M., & Hoffman, L. (2023): Drug-resistant bacteria from “farm to fork”: Impact of antibiotic use in animal production. In D. W. Schaffner (Ed.), Present knowledge in food safety (pp. 871–892). |
APA Style
Melese, M., Abdu, B., Fentahun, S., Girma, S., Genobaye, I., et al. (2025). Review on Addressing Antimicrobial Resistance in Livestock Through a One Health Approach. American Journal of Zoology, 8(4), 85-92. https://doi.org/10.11648/j.ajz.20250804.12
ACS Style
Melese, M.; Abdu, B.; Fentahun, S.; Girma, S.; Genobaye, I., et al. Review on Addressing Antimicrobial Resistance in Livestock Through a One Health Approach. Am. J. Zool. 2025, 8(4), 85-92. doi: 10.11648/j.ajz.20250804.12
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Download@article{10.11648/j.ajz.20250804.12,
author = {Melkamu Melese and Biruktawit Abdu and Selamawit Fentahun and Samrawit Girma and Isael Genobaye and Ejigayehu Demssie},
title = {Review on Addressing Antimicrobial Resistance in Livestock Through a One Health Approach
},
journal = {American Journal of Zoology},
volume = {8},
number = {4},
pages = {85-92},
doi = {10.11648/j.ajz.20250804.12},
url = {https://doi.org/10.11648/j.ajz.20250804.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajz.20250804.12},
abstract = {Antimicrobial resistance (AMR) has emerged as one of the most pressing global health threats of the 21st century, jeopardizing the effective treatment of infectious diseases across humans, animals, and the environment. In livestock production, antimicrobials are widely used for therapeutic, prophylactic, and growth-promoting purposes. Therefore, the objective of this review is to examine the application of One Health approaches in addressing AMR in livestock and to identify key challenges and opportunities for their effective implementation. The inappropriate and excessive use of antimicrobials in animals has accelerated the emergence and spread of resistant pathogens. These resistant bacteria can be transmitted to humans through direct contact, food consumption, and environmental contamination, posing significant risks to public health, food security, and economic stability. Addressing AMR from a single-sector perspective has proven inadequate. A One Health approach which recognizes the interdependence of human, animal, and environmental health offers a more sustainable and effective solution. Despite growing global and national advocacy for One Health strategies, implementation remains inconsistent, particularly in the livestock sector. In many low- and middle-income countries, antimicrobial use in animals is poorly regulated, data on usage and resistance patterns are limited, and cross-sectoral collaboration is weak. Although One Health frameworks exist, their operationalization in livestock systems is hindered by gaps in policy, coordination, and technical capacity. In conclusion, AMR in livestock is a complex issue that requires a collaborative, multisectoral response. Strengthening the One Health approach is essential to tackle AMR at its source. As a key recommendation, countries should establish a national One Health coordination platform that brings together stakeholders from human, animal, and environmental health sectors to implement harmonized surveillance, promote responsible antimicrobial use, and support education and capacity building. Strong political commitment and sustained investment are crucial for achieving long-term impact.
},
year = {2025}
}
TY - JOUR T1 - Review on Addressing Antimicrobial Resistance in Livestock Through a One Health Approach AU - Melkamu Melese AU - Biruktawit Abdu AU - Selamawit Fentahun AU - Samrawit Girma AU - Isael Genobaye AU - Ejigayehu Demssie Y1 - 2025/10/31 PY - 2025 N1 - https://doi.org/10.11648/j.ajz.20250804.12 DO - 10.11648/j.ajz.20250804.12 T2 - American Journal of Zoology JF - American Journal of Zoology JO - American Journal of Zoology SP - 85 EP - 92 PB - Science Publishing Group SN - 2994-7413 UR - https://doi.org/10.11648/j.ajz.20250804.12 AB - Antimicrobial resistance (AMR) has emerged as one of the most pressing global health threats of the 21st century, jeopardizing the effective treatment of infectious diseases across humans, animals, and the environment. In livestock production, antimicrobials are widely used for therapeutic, prophylactic, and growth-promoting purposes. Therefore, the objective of this review is to examine the application of One Health approaches in addressing AMR in livestock and to identify key challenges and opportunities for their effective implementation. The inappropriate and excessive use of antimicrobials in animals has accelerated the emergence and spread of resistant pathogens. These resistant bacteria can be transmitted to humans through direct contact, food consumption, and environmental contamination, posing significant risks to public health, food security, and economic stability. Addressing AMR from a single-sector perspective has proven inadequate. A One Health approach which recognizes the interdependence of human, animal, and environmental health offers a more sustainable and effective solution. Despite growing global and national advocacy for One Health strategies, implementation remains inconsistent, particularly in the livestock sector. In many low- and middle-income countries, antimicrobial use in animals is poorly regulated, data on usage and resistance patterns are limited, and cross-sectoral collaboration is weak. Although One Health frameworks exist, their operationalization in livestock systems is hindered by gaps in policy, coordination, and technical capacity. In conclusion, AMR in livestock is a complex issue that requires a collaborative, multisectoral response. Strengthening the One Health approach is essential to tackle AMR at its source. As a key recommendation, countries should establish a national One Health coordination platform that brings together stakeholders from human, animal, and environmental health sectors to implement harmonized surveillance, promote responsible antimicrobial use, and support education and capacity building. Strong political commitment and sustained investment are crucial for achieving long-term impact. VL - 8 IS - 4 ER -
College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia
School of Veterinary Medicine, Wollo University, Dessie, Ethiopia
School of Veterinary Medicine, Wollo University, Dessie, Ethiopia
Masha Woreda Livestock and Fishery Office, South West Regional State, Ethiopia
School of Veterinary Medicine, Wollo University, Dessie, Ethiopia
College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia
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