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Septal Rupture Complicating a Myocardial Infarction: A Case Report from the Cardiology Department of the Kara Teaching Hospital

Received: 22 February 2026     Accepted: 13 March 2026     Published: 27 March 2026
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Abstract

Post- myocardial infarction ventricular septal rupture is a rare but very fatal complication if early and appropriate management is not provided or is delayed. Despite medical advances in treatment, the mortality rate associated with ventricular septal rupture following myocardial infarction remains very high. We report the case of a 65-year-old woman with a history of alcohol abuse, hospitalized in the cardiology department of Kara Teaching Hospital for an anteroseptal ST elevation myocardial infarction that was not treated with thrombolysis. The patient's condition was marked by the occurrence of a ventricular septal rupture on the third day, followed by death on the fourth day, without surgical repair of the septum. This case illustrates the severity of the mechanical complications of myocardial infarction. The lack of cardiac surgery in Togo constitutes a fatal obstacle to the management of certain cardiac pathologies, such as post-myocardial infarction ventricular septal rupture. Hence the need to improve the local technical platform to ensure better patient care.

Published in Cardiology and Cardiovascular Research (Volume 10, Issue 1)
DOI 10.11648/j.ccr.20261001.12
Page(s) 7-10
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2026. Published by Science Publishing Group

Keywords

Myocardial Infarction, Ventricular Septal Rupture, Togo

1. Introduction
Post- myocardial infarction ventricular septal rupture is a rare but serious complication, as it is life-threatening if early and appropriate treatment is not provided or is delayed. This ventricular septal rupture occurs at the junction between healthy and infarcted tissue . It is an extreme medical-surgical emergency requiring multidisciplinary management involving emergency physicians, cardiologists, and cardiovascular surgeons . Before the era of thrombolysis, the reported incidence of post-myocardial infarction septal rupture was 11% in histopathological series and 1 to 2% of patients hospitalized for myocardial infarction. Today, the incidence rate is 0.2%, thanks to various early recanalization techniques . Despite medical advances in management, the mortality rate associated with ventricular septal defects following myocardial infarction remains very high exceeding 90% without surgical or interventional treatment . After surgical or percutaneous closure, mortality rate is approximately 30 to 40% at 30 days . In Togo, as in most African countries, data on ventricular septal rupture complicating myocardial infarction are scarce . Thus, we report the case of a post-myocardial infarction ventricular septal rupture observed in the cardiology department of the Kara Teaching Hospital.
2. Clinical Observation
This was a 65-year-old female homemaker admitted to the cardiology department of the Kara teaching Hospital for chest pain. The onset of symptoms dated back approximately six days prior to admission, marked by the sudden onset of angina-like chest pain that occurred intermittently. This initial episode was treated unsuccessfully at a peripheral health facility with gastric protectants, analgesics, and non-steroidal anti-inflammatory drugs. Due to the persistence of the chest pain, the patient was transferred to the cardiology department of the Kara teaching Hospital for more appropriate management. She had no major cardiovascular risk factors or known medical history. She was a known alcoholic.
The clinical examination on admission revealed: good hemodynamic status (blood pressure 125/67 mmHg, heart rate 80 bpm, respiratory rate 19 breaths per minute, oxygen saturation 98% on room air); good level of consciousness (Glasgow Coma Scale score 15/15); and no signs of heart failure. There was no heart murmur on auscultation.
The electrocardiogram showed a baseline sinus rhythm with a heart rate of 78 bpm, an isolated atrial premature beat, left ventricular hypertrophy, and ST elevation in the anteroseptal and inferior leads (anteroseptal and inferior STEMI) with reciprocal changes in the superior lateral leads.
Cardiac Doppler ultrasound revealed dilation of the left heart chambers (LVEDD = 58.3 mm; LAA = 22.11 cm²) with good left ventricular systolic function (LVEF = 69% on the biplan). There was akinesis of the mid and apical segments of the septal and inferoseptal walls. Left ventricular filling pressures were elevated (E/A = 2.03, E/E' = 14). The right ventricle had normal morphology with good systolic function (TAPSE = 21 mm). There was pulmonary hypertension (SPAP = 60 mmHg).
The frontal chest X-ray had revealed cardiomegaly with a cardiothoracic index of 0.74, associated with straightness of the left middle arch, lengthening of the left lower arch with the apex subdiaphragmatic and overhang with double contour appearance of the right lower arch.
Laboratory tests revealed that troponin I was elevated at 4979 ng/ml, 248 times the normal level; urea was 1.73 g/l; creatinine was 0,043 g/l with a glomerular filtration rate of 17 ml/min; random blood glucose was 2.66 g/l; a complete blood count showed leukocytosis of 15,450/mm³ with neutrophilia of 13.97 G/l and normochromic microcytic anemia of 104 g/l; serum electrolytes were within normal limits; and C-reactive protein was elevated at 0,214 g/l. Neither primary angioplasty nor thrombolysis was performed due to a lack of funding. She only received treatment consisting of: therapeutic dose anticoagulation (sodium heparin), dual antiplatelet therapy (aspirin + clopidogrel), statin (atorvastatin), antibiotic therapy (ceftriaxone), insulin therapy (actrapid), diuretic (furosemide).
The patient's condition was marked by the onset, on the third day, of cardiogenic shock with a blood pressure of 80/56 mmHg. Cardiac auscultation revealed a loud harsh pansystolic murmur. Doppler cardiac ultrasound showed a ventricular septal defect (Figure 1) in the mid-ventricular segment with a left-to-right shunt (Figure 2). Since repair of the ventricular septal defect (surgery or angioplasty) was not possible in the department, the patient received only treatment for shock (vasopressors), with no success. On the fourth day of her admission, she experienced a cardiorespiratory arrest, which was unsuccessfully resuscitated.
Figure 1. Apical 4-chamber view showing post-myocardial infarction ventricular septal defect.
Figure 2. Parasternal short-axis view, transventricular section showing post-myocardial infarction ventricular septal rupture with left-to-right shunt.
3. Discussion
Myocardial infarction is a serious and potentially fatal cardiovascular emergency due to its complications, including septal or free wall rupture of the left ventricle. It is a formidable complication because in-hospital mortality remains high, despite advances in early management . The overall incidence remains difficult to assess, as many patients die in the pre-hospital phase without confirmation of the cause of death .
Post-myocardial infarction ventricular septal rupture occurs in approximately 0.5% of ST elevation myocardial infarction, on average within 3 to 5 days post-myocardial infarction. It is most often the initial, extensive defect and is caused in most cases by a single-vessel lesion of the culprit coronary artery, with a small collateral network . Doppler echocardiography, performed as soon as a diffuse pansystolic murmur appears, allows for a definitive diagnosis, highlighting the defect in two-dimensional mode and the left-to-right shunt on color Doppler. Transesophageal echocardiography also allows for a definitive diagnosis in patients with poor echocardiographic images . In our patient, the septal rupture occurred on the third day of hospitalization, suspected due to a pansystolic murmur again associated with shock, and confirmed by Doppler echocardiography, which visualized the lesion.
The main factors implicated in the occurrence of septal rupture in this clinical case were: advanced age related to senescence and the loss of the myocardium's self-protective capacity; female sex, which is thought to be more susceptible to rupture due to the presence of structural collagen more often found in women ; the absence of a history of angina or myocardial infarction , explaining the lack of development of collateral circulation, and especially the complete occlusion of the responsible artery and the creation of extensive necrosis exposing to septal rupture ; and finally the absence of early reperfusion, which remains the main risk factor .
Treatment of a septal defect is surgical and consists of closure with a prosthetic patch. Ideally, the patient is presented to the surgeon in optimal hemodynamic conditions with appropriate resuscitation management (intra-aortic balloon pump, positive inotropic agents) as soon as possible . As in most sub-Saharan countries, the technical infrastructure is insufficient, and such treatments are impossible. Indeed, the lack of cardiac surgery in Togo constitutes an obstacle to the management of certain cardiac pathologies, such as post-myocardial infarction septal rupture. The main prognostic factors for septal rupture identified in the literature are the severity of global systolic dysfunction secondary to the infarction and the extent of the septal defect, the main clinical manifestation of which is hemodynamic instability. Once shock develops, the prognosis is even worse, with very high mortality . This was the case for the patient in the clinical case, who died in less than 24 hours after the onset of shock.
4. Conclusion
We have illustrated one of the rare complications of myocardial infarction: post-myocardial infarction septal rupture. This complication is primarily associated with inadequate treatment of myocardial infarction, particularly thrombolysis. Hence the importance of optimizing the management of myocardial infarction in the acute phase.
Abbreviations

STEMI

ST Elevation Myocardial Infarction

LAA

Left Atrial Area

LVEDD

Left Ventricular End- Diastolic Diameter

LVEF

Left Ventricular Ejection Fraction

SPAP

Systolic Pulmonary Artery Pressure

TAPSE

Tricuspid Annular Plane Systolic Excursion

Author Contributions
Tchaa Tcherou: Conceptualization, Methodology, Formal Analysis, Funding acquisition, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Fiacre Odilon Tolmbaye Sem: Conceptualization, Methodology, Formal Analysis, Funding acquisition, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Clementine Pascale Zoalang Abena: Data curation, Investigation
Djindimadje Allarangue: Data curation, Investigation
Olga Lakpa: Data curation, Investigation
John Michael Ngalle Mbondjo: Data curation, Investigation
Ayao Sergio Spero De Souza: Data curation, Investigation
Gottara Winigah Soga: Data curation, Investigation
Doguensaga Borgatia Atta: Conceptualization, Methodology, Formal Analysis, Funding acquisition, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Abalo Mario Bakai: Conceptualization, Methodology, Formal Analysis, Funding acquisition, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Komlavi Yayehd: Conceptualization, Methodology, Formal Analysis, Funding acquisition, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Machihude Pio: Conceptualization, Methodology, Formal Analysis, Funding acquisition, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Conflicts of Interest
The authors declare no conflicts of interest.
References
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  • APA Style

    Tcherou, T., Sem, F. O. T., Abena, C. P. Z., Allarangue, D., Lakpa, O., et al. (2026). Septal Rupture Complicating a Myocardial Infarction: A Case Report from the Cardiology Department of the Kara Teaching Hospital. Cardiology and Cardiovascular Research, 10(1), 7-10. https://doi.org/10.11648/j.ccr.20261001.12

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    ACS Style

    Tcherou, T.; Sem, F. O. T.; Abena, C. P. Z.; Allarangue, D.; Lakpa, O., et al. Septal Rupture Complicating a Myocardial Infarction: A Case Report from the Cardiology Department of the Kara Teaching Hospital. Cardiol. Cardiovasc. Res. 2026, 10(1), 7-10. doi: 10.11648/j.ccr.20261001.12

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    AMA Style

    Tcherou T, Sem FOT, Abena CPZ, Allarangue D, Lakpa O, et al. Septal Rupture Complicating a Myocardial Infarction: A Case Report from the Cardiology Department of the Kara Teaching Hospital. Cardiol Cardiovasc Res. 2026;10(1):7-10. doi: 10.11648/j.ccr.20261001.12

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  • @article{10.11648/j.ccr.20261001.12,
      author = {Tchaa Tcherou and Fiacre Odilon Tolmbaye Sem and Clementine Pascale Zoalang Abena and Djindimadje Allarangue and Olga Lakpa and John Michael Ngalle Mbondjo and Ayao Sergio Spero De Souza and Gottara Winigah Soga and Doguensaga Borgatia Atta and Abalo Mario Bakai and Komlavi Yayehd and Machihude Pio},
      title = {Septal Rupture Complicating a Myocardial Infarction: 
    A Case Report from the Cardiology Department of the Kara Teaching Hospital},
      journal = {Cardiology and Cardiovascular Research},
      volume = {10},
      number = {1},
      pages = {7-10},
      doi = {10.11648/j.ccr.20261001.12},
      url = {https://doi.org/10.11648/j.ccr.20261001.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20261001.12},
      abstract = {Post- myocardial infarction ventricular septal rupture is a rare but very fatal complication if early and appropriate management is not provided or is delayed. Despite medical advances in treatment, the mortality rate associated with ventricular septal rupture following myocardial infarction remains very high. We report the case of a 65-year-old woman with a history of alcohol abuse, hospitalized in the cardiology department of Kara Teaching Hospital for an anteroseptal ST elevation myocardial infarction that was not treated with thrombolysis. The patient's condition was marked by the occurrence of a ventricular septal rupture on the third day, followed by death on the fourth day, without surgical repair of the septum. This case illustrates the severity of the mechanical complications of myocardial infarction. The lack of cardiac surgery in Togo constitutes a fatal obstacle to the management of certain cardiac pathologies, such as post-myocardial infarction ventricular septal rupture. Hence the need to improve the local technical platform to ensure better patient care.},
     year = {2026}
    }
    

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Author Information
  • Department of Cardiology, Kara Teaching Hospital, Kara, Togo

  • Department of Cardiology, Kara Teaching Hospital, Kara, Togo

  • Department of Cardiology, Kara Teaching Hospital, Kara, Togo

  • Department of Cardiology, Kara Teaching Hospital, Kara, Togo

  • Department of Cardiology, Kara Teaching Hospital, Kara, Togo

  • Department of Cardiology, Kara Teaching Hospital, Kara, Togo

  • Department of Cardiology, Kara Teaching Hospital, Kara, Togo

  • Department of Cardiology, Kara Teaching Hospital, Kara, Togo

  • Department of Cardiology, Sokode Regional Hospital, Sokode, Togo

  • Department of Cardiology, Kara Teaching Hospital, Kara, Togo

  • Department of Cardiology, Campus Teaching Hospital, Lome, Togo

  • Department of Cardiology, Kara Teaching Hospital, Kara, Togo