American Journal of BioScience

Special Issue

Oxidants-Antioxidants, The Biological Balance

  • Submission Deadline: 30 March 2015
  • Status: Submission Closed
  • Lead Guest Editor: Mahmoud Ibrahim
About This Special Issue
Imbalance between the production of reactive oxygen species (ROS) and the detoxification of their reactive intermediates by antioxidants causes oxidative stress. Cells must respond to this imbalance before the highly reactive molecules damage cellular structures, particularly DNA. Severe and prolonged oxidative stress can trigger apoptosis and necrosis. Numerous pathological conditions have an oxidative stress component, including cataract, leukemia, melanoma, renal failure, diabetes, cardiovascular diseases and neurodegenerative diseases such as Alzheimer. Signaling pathways downstream of ROS detection phosphorylate the transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) which binds the antioxidant response element within the promoters of genes encoding antioxidant enzymes and detoxifying enzymes. Key Nrf2 target genes include antioxidants such as glutathione peroxidases (GPx) and genes involved in superoxide metabolism. These genes, in addition to some other antioxidants, reduce oxidative stress by breaking down ROS. Analysis of oxidants-antioxidants balance may yield new insights or new approach to how dealing with many diseases and cancer.

This special issue could serve as a background for the diseases which are due to oxidative stress and the role of antioxidants in scavenging the reactive oxygen species.
Lead Guest Editor
  • Mahmoud Ibrahim

    Physics Department, Faculty of Science, Suez University, Suez, Egypt

Guest Editors
  • Lei Wang

    Johns Hopkins University, School of Medicine, Wilmer Eye Institute, Baltimore, United States

  • Bahram Alamdary Badlou

    Research and Development Department, BBAdvies and Research Company (before University Medical Center Utrecht), Zeist, Netherlands

  • Sudhir Rai

    Department of Oral & Maxillofacial Surgery, Index institute of dental sciences, Bethesda, United States

  • Gláucio Diré Feliciano

    Analysis Laboratory Chemical and Biological (LAQB), Sector Center for Biological and Health Sciences, Foundation State University Center of the West Zone (UEZO), University of Pharmacy Unit (UFAR), Rio de Janeiro, Brazil

  • Jing Zhang

    Frontier Institute of Science and Techonogy, Xi'an Jiaotong University, China

  • Yanbo Hu

    College of Life Science, Northeast Forestry University, Harbin, China

  • Noel Unciano

    Environment and Biotechnology Division, Industrial Technology Development Institute, Taguig, Philippines

  • Issa Ibraheem

    Biomedical Engineering, Damascus University, Faculty of Biomedical Engineering, Damascus, Syria

  • Ahmad Ali

    Department of Life Sciences, University of Mumbai, Mumbai, India

  • Seifollah Bahramikia

    Department of Biology, Lorestan University, Khoramabad, Iran

Published Articles
  • Expression of Metallothioneins in Placental and Fetal Tissues in Undisturbed and PGM-Zn Treated Syngeneic Pregnancy

    Hrvoje Jakovac , Damir Grebić , Ines Mrakovcic-Šutić , Daniel Rukavina , Biserka Radošević-Stašić

    Issue: Volume 3, Issue 2-2, April 2015
    Pages: 1-7
    Received: 16 January 2015
    Accepted: 19 January 2015
    Published: 2 March 2015
    DOI: 10.11648/j.ajbio.s.2015030202.12
    Abstract: Metallothioneins (MTs) are cysteine-rich proteins, which have been implicated in regulation of physiological processes, such as cell growth, repair, differentiation, apoptosis and immunoregulation, as well as in the protection against heavy metals, oxidant damages, inflammation and other stressful conditions. To investigate their roles in physiolog... Show More