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Research Article
Evaluation of the Therapeutic Properties of the Aqueous Extract of Picralima nitida Seeds in Diabetic Rats
Bangnie Gueladjibi Landry,
Kouadio Kouakou John*,
Ouattara-Soro Fatou Shcherazade
Issue:
Volume 13, Issue 2, April 2025
Pages:
43-48
Received:
9 February 2025
Accepted:
19 February 2025
Published:
6 March 2025
DOI:
10.11648/j.ajbio.20251302.11
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Abstract: Picralima nitida seeds are used in traditional medicine to treat cough, bronchitis and headache, hernia, vomiting, diarrhea and finally leucorrhoea. The aim of this work was to evaluate the therapeutic effect of the aqueous extract of Picralima seeds nitida on hyperglycemia in rats. The antidiabetic activity of the aqueous extract of P. nitida seeds was evaluated in diabetic rats. For this purpose, diabetes was induced in rats by intraperitoneal injection of a single dose of 150 mg/kg MC of alloxan solution. After induction, rats were given anhydrous glucose solution (5%) overnight to overcome the hyperglycemic shock induced by the action of alloxan, and then the animals were treated. P. nitida extract caused a marked recovery of body mass in diabetic rats. P. nitida extract resulted in a significant reduction in induced hyperglycemia in diabetic rats. Regarding biochemical parameters, P. nitida seeds resulted in a marked improvement in the physiological state of rats by reducing biochemical parameters such as urea, ASAT, ALAT, creatinine, and uric acid as well as lipid and protein parameters. Administration of P. nitida seeds promoted the production of alpha amylase and lipase in diabetic rats. The use of this plant in the treatment of diabetic rats would therefore justify the therapeutic properties of P. nitida seeds.
Abstract: Picralima nitida seeds are used in traditional medicine to treat cough, bronchitis and headache, hernia, vomiting, diarrhea and finally leucorrhoea. The aim of this work was to evaluate the therapeutic effect of the aqueous extract of Picralima seeds nitida on hyperglycemia in rats. The antidiabetic activity of the aqueous extract of P. nitida seed...
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Research Article
Amino Acid Profile of Pila globosa Swainson in Active and Aestivation Periods
Umme Habiba Shathi,
Md Redwanur Rahman*
,
Most Shamima Akther Shampa
Issue:
Volume 13, Issue 2, April 2025
Pages:
49-54
Received:
9 February 2025
Accepted:
4 March 2025
Published:
26 March 2025
Abstract: The snail Pila globosa's amino acid composition was examined. To analyse the amino acids in the snail meat, samples were taken from the Chalan Beel at various times. The BCSIR, ITTI lab in Dhaka, Bangladesh is where the amino acid analysis is carried out. Following a 300-400 mg weight measurement, 12 ml of HCl was added, and the mixture was vortexed. It was then hydrolyzed for 24 hours at 102˚C with a pH adjustment (1.95-2.00). Leucine was shown to be the predominant essential amino acid throughout both the active and aestivation periods, whereas glutamic acid was the most prevalent non-essential amino acid. Eight essential and nine non-essential amino acid types made up the total of 17 amino acid types discovered. While the percentage of non-essential amino acids was 71.2% and 72.7%, respectively, the rate of essential amino acids was 28.8% and 27.3%. Compared to snail meat during the active period, snail meat during the aestivation period has a greater amino acid profile. The essential amino acids valine, isoleucine, lysine, and phenylalanine were below the necessary level in both seasons, whereas methionine was in the margin line. The study concluded that, based on their circumstances, eating snail meat should be advised for a variety of malnourished individuals.
Abstract: The snail Pila globosa's amino acid composition was examined. To analyse the amino acids in the snail meat, samples were taken from the Chalan Beel at various times. The BCSIR, ITTI lab in Dhaka, Bangladesh is where the amino acid analysis is carried out. Following a 300-400 mg weight measurement, 12 ml of HCl was added, and the mixture was vortexe...
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Review Article
Pathophysiology of Atherosclerosis in Psoriatic Arthritis: New Insights into Inflammation and Lipid Metabolism
Marius Semionov,
Eugeniu Russu*
Issue:
Volume 13, Issue 2, April 2025
Pages:
55-68
Received:
20 March 2025
Accepted:
28 March 2025
Published:
17 April 2025
DOI:
10.11648/j.ajbio.20251302.13
Downloads:
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Abstract: Introduction: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with heightened cardiovascular morbidity, primarily due to accelerated atherosclerosis. Despite increasing evidence linking PsA to endothelial dysfunction, dyslipidemia, and chronic inflammation, cardiovascular risk assessment in PsA remains underdeveloped. This literature review synthesizes current evidence on the shared pathophysiological mechanisms between PsA and atherosclerosis. Materials and methods: A systematic search of PubMed, MEDLINE, Embase, Cochrane Library, Web of Science, and Scopus was conducted to identify studies published between 1990 and 2025. Studies were selected based on relevance to inflammatory pathways, lipid metabolism, and immune-mediated endothelial dysfunction in PsA-related atherosclerosis. Results: PsA contributes to atherosclerosis through persistent systemic inflammation, driven by key cytokines such as IL-17, IL-23, TNF-α, and IL-22. These mediators promote endothelial dysfunction, increased leukocyte adhesion, and plaque formation. Altered lipid metabolism in PsA patients, particularly dysfunctional HDL characterized by impaired cholesterol efflux and pro-inflammatory modifications, further exacerbates cardiovascular risk. Additionally, a disrupted Th17/Treg balance perpetuates vascular inflammation and atherogenesis. The interplay between immune dysregulation and metabolic alterations underscores the systemic nature of PsA and its cardiovascular complications. Conclusion: PsA-associated systemic inflammation accelerates atherosclerosis through immune-mediated endothelial dysfunction and lipid metabolism disturbances. Current cardiovascular risk assessment models fail to capture this increased burden. Targeting IL-17, IL-23, and TNF-α, alongside restoring HDL functionality, may offer novel therapeutic strategies. Future research should focus on longitudinal studies to better characterize cardiovascular outcomes in PsA patients and guide tailored interventions to mitigate atherosclerotic risk.
Abstract: Introduction: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with heightened cardiovascular morbidity, primarily due to accelerated atherosclerosis. Despite increasing evidence linking PsA to endothelial dysfunction, dyslipidemia, and chronic inflammation, cardiovascular risk assessment in PsA remains underdeveloped. This li...
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