American Journal of BioScience

Special Issue

Adult and Reparative Neurogenesis: Actual Questions

  • Submission Deadline: 20 February 2015
  • Status: Submission Closed
  • Lead Guest Editor: Evgeniya Pushchina
About This Special Issue
In the Special issue, we would like to consider the actual issues of adult and reparative neurogenesis and the expected means of regulating these processes and participation of neurochemical intercellular signaling in spatio-temporal organization of these processes. Currently, great attention concentrated on a questions about interaction of nervous and immune systems and the involvement of these systems in the organization of inflammatory responses after brain and spinal cord injuries. Interesting and relevant techniques are in vivo video monitoring of immune system´s cells, involved in the inflammatory response after trauma of CNS. Speed of the cellular response in traumatic brain injuries determinates by the relationship between proliferation and apoptosis. Efficiency of repair processes associated with the process of elimination and disposal of damaged cells in brain´s centers or pathways. Factors of neuroprotection are other relevant substances, which protect cells from the toxic effects of inflammatory mediators and therefore contribute to a more rapid recovery of damaged areas of CNS. Gaseous mediators, such as NO, H2S and CO have low molecular weight and play a major role in intercellular communications during reparative processes and traumatic injury. Their broad regulatory influence extends to various aspects of the functional activity of central nervous system in normal conditions and after damaged influence. Particular attention in this issue will be paid to morphogenetic influence of such agents. As a result of adult and reparative neurogenesis in proliferative areas of brain generated various types of cells, including neurons. The rate of generation of new neurons in proliferative areas of brain determines the effectiveness of reparative neurogenesis. Exploration of new regenerative-associated factors involved in the production of new cells in the adult brain and determine the success of the repair in regenerative competent organisms for understanding of mechanisms these processes have great importance.
Lead Guest Editor
  • Evgeniya Pushchina

    Laboratory of Cytophysiology, A.V., Zhirmunskii Institute of Marine Biology, Russian Academy of Science, Vladivostok, Russian Federation

Guest Editors
  • Sachin Shukla

    SSR Stem Cell Laboratory, Prof. Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, India

  • Anatoly Varaksin

    Institute of Marine Biology, Vladivostok, Russian Federation

Published Articles
  • Monitoring of Cell Migration and Apoptosis in Cerebellum of Juvenile Masu Salmon Oncorhynchus Masou After Injury

    Stukaneva M. E. , Puschina E. V. , Varaksin A. A. , Shukla S.

    Issue: Volume 3, Issue 2-3, April 2015
    Pages: 19-27
    Received: 23 February 2015
    Accepted: 24 February 2015
    Published: 5 March 2015
    DOI: 10.11648/j.ajbio.s.2015030203.13
    Abstract: Apoptosis in various cerebellar zones of juvenile masu salmon Oncorhynchus masou after mechanical injury was investigated by TUNEL-labeling. In the brain of 4 month-old juveniles of O. masou growth in different parts of cerebellum and proliferative activity in secondary matrix zones of cerebellum were continued. TUNEL-labeling was observed in the i... Show More
  • Multiphoton Confocal Microscopy (in vivo Imaging) in the Study of Early Response of Macrophages/Microglia in Damaged Midbrain of Juvenile Chum Salmon Oncorhynchus keta

    Pushchina E. V. , Varaksin A. A. , Shukla S. , Bulygyn D. A.

    Issue: Volume 3, Issue 2-3, April 2015
    Pages: 12-18
    Received: 15 February 2015
    Accepted: 19 February 2015
    Published: 5 March 2015
    DOI: 10.11648/j.ajbio.s.2015030203.12
    Abstract: We used multiphoton confocal microscopy for the in vivo study of early response of macrophages/microglia in the damaged midbrain of juvenile chum salmon Oncorhynchus keta. The results obtained allow the use of injection of DiI in the area of brain injury as a method to identify a population of phagocytic cells in the brain, based on the physiologic... Show More
  • Undifferentiated Catecholaminergic and NO-Producing Cells of Forebrain Matrix Zones and Intercellular Relationships in Periventricular Diencephalon of Juvenile Oncorhynchus masou

    Pushchina E. V. , Varaksin A. A. , Shukla S. , Obukhov D. K.

    Issue: Volume 3, Issue 2-3, April 2015
    Pages: 1-11
    Received: 14 January 2015
    Accepted: 17 January 2015
    Published: 5 March 2015
    DOI: 10.11648/j.ajbio.s.2015030203.11
    Abstract: Localization of TH- and NO-producing systems in the diencephalon of juvenile masu salmon Oncorhynchus masou was investigated by using histofluorescence labeling of glyoxylic acid (GA), and ICH labeling of tyrosine hydroxylase (TH) and neuronal nitric oxide synthase (nNOS). High density distribution of catecholaminergic and NO-ergic cells has been f... Show More