Relationship Between Parasitic Infections in Diabetic Patients and the Importance of Raman Spectroscopy in Determining Parasites at Molecular Level
Berna Hamamci,
Gunes Acikgoz
Issue:
Volume 7, Issue 4, December 2019
Pages:
41-46
Received:
3 December 2019
Accepted:
16 December 2019
Published:
25 December 2019
Abstract: Diabetes mellitus (DM) is a metabolic disorder of protein, carbohydrate and fat. Insulin secretion, insulin action, or both cause to diabetes mellitus. According to the World Health Organization, the number of diabetic patients in the world is around 200 million and it is stated that this number will reach 300 million in 2025. Parasitic diseases are widespread all over the world and are a major public health problem, especially in underdeveloped or developing countries. It ranks first among the diseases that should be controlled by the World Health Organization. Among the factors causing parasitic diseases include protozoa, helminths and arthropods. In certain geographical areas where parasitic infections are common, many autoimmune diseases such as asthma, rheumatoid arthritis (RA), type1diabetes (T1DM), multiple sclerosis (MS), and inflammatory bowel diseases (IBD) are reported to have a lower incidence. The relationship between helminth infections on the onset and development of T1DM, one of the multigenetic diseases affected by environmental factors, is remarkable. It is not clear how helminth infections prevent T1DM development. In diabetic patients, it is known that there is a decrease in immune system functions, especially cellular immunity, and in these patients CD8 and CD16 values for suppressor T cells and NK cells are decreased compared to normal individuals. Therefore, it does not prevent the development of diabetes and can be seen more in patients with diabetes. Raman Spectroscopy (RS) is a vibrational technique due to inelastic scattering that occurs during the interaction of monochromatic laser beams with molecules. It is preferred in biomedical examinations because RS does not damage the sample and can be obtained quickly by non-invasive method. DM and different parasitic diseases can be determined by analyzing the spectra obtained in RS examinations. The obtained Raman spectra of different molecular systems are different and each system has its own fingerprint.
Abstract: Diabetes mellitus (DM) is a metabolic disorder of protein, carbohydrate and fat. Insulin secretion, insulin action, or both cause to diabetes mellitus. According to the World Health Organization, the number of diabetic patients in the world is around 200 million and it is stated that this number will reach 300 million in 2025. Parasitic diseases ar...
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Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar
Rakotomalala Toky Randriamahazo,
Zoliarisoa Ramihajamanana,
Anjatiana Annick Raherinaivo,
Miora Rasamindrakotroka,
Davidra Rajaonatahina,
Olivat Rakoto Alson,
Andry Rasamindrakotroka
Issue:
Volume 7, Issue 4, December 2019
Pages:
47-50
Received:
14 January 2020
Accepted:
27 January 2020
Published:
13 February 2020
Abstract: Currently, there are 122 hemophiliacs in Madagascar followed at the hemophiliac treatment center of the Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC), 55 present hemophilia B and 67 of hemophilia A. In hemophilic patients, the diagnosis of hemarthrosis is obviousin front of articular inflammation. It’s important to determinate the main risk factor as well as predisposition indicators tothe occurrence of "spontaneous" hemarthrosis in hemophiliacsfor prevention andearly careanticipation. In this prospect, the search for potentpredisposition indicator such as immunologicalfactorsis important. This is a case control study on all hemophiliacs seen at (JRA UHC) with hemarthrosis for 7 months. We have descriptively studied the qualitative and quantitative variables consisting in the determination of rheumatoid factors (RF) and the titer of antistreptolysin O (ASLO). Then we studied the statistical correlations. During the study period, we included 30 hemophiliac subjects with hemarthrosis who had an average age of 16.8 years. We had as much hemophiliac A as hemophiliac B; 23.3% practiced sporting activity; 10% had history of angina, involvement of the knee joint predominated at 44% (left 24%). RF positive were present in 26.7% (8/30) predominant in hemophiliacs aged from 19 to 36 (62.5%). The ASLO positive titer was found in 43.3% (13/30) predominant in children from 5 to 13 years (38.5%) with a maximum rate of 1600IU / l. There was no significant relationship between the positivity of the parameters with the presence or absence of hemarthrosis with a value of p = 0.231 and p = 0.06 respectively (p > 0.05). A large number of hemophiliac patients had a combination of clinical and biological signs in relation to diagnose rheumatic fever and rheumatoid arthritis which must be monitored as this could predict the occurrence in the short and medium term of these diseases which could be mistaken for hemarthrosisrelated to hemophilia.
Abstract: Currently, there are 122 hemophiliacs in Madagascar followed at the hemophiliac treatment center of the Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC), 55 present hemophilia B and 67 of hemophilia A. In hemophilic patients, the diagnosis of hemarthrosis is obviousin front of articular inflammation. It’s important to determina...
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