Facile New Syntheses of Substituted Benzhydryl Derivatives Using Trichloroacetimidate C-C Bond Formation Method
Issue:
Volume 2, Issue 5, October 2014
Pages:
38-43
Received:
17 November 2014
Accepted:
26 November 2014
Published:
5 December 2014
Abstract: An improved syntheses of substituted benzhydryl derivatives has been developed. This facile two-step procedure involves C-C bond formation from O-diphenylmethyltrichloroacetimidate and C-nucleophiles in the presence of TMSOTf. The C-nucleophiles include arenes, alkenes, alkene silylated C-nucleophiles and trimethylsiloxy alkenes to give a series substituted benzhydryl derivatives in excellent yields.
Abstract: An improved syntheses of substituted benzhydryl derivatives has been developed. This facile two-step procedure involves C-C bond formation from O-diphenylmethyltrichloroacetimidate and C-nucleophiles in the presence of TMSOTf. The C-nucleophiles include arenes, alkenes, alkene silylated C-nucleophiles and trimethylsiloxy alkenes to give a series su...
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