Abstract: Sorghum is an important cereal crop used as human a staple food grain in many semi-arid and tro pical areas of the world, notably is Sub-Saharan Africa and Asian continents by approximately 500 million people due to its good agronomic properties in harsh environment. It is known that sorghum is a gluten-free cereal used as ground flour and it is a source of energy, protein, vitamins, minerals, and as antioxidant phenolics and cholesterol- lowering waxes. The Physicochemical characteristics of sorghum flour were determined for ten recently improved and released sorghum varieties cultivated in Ethiopia were analyzed for proximate composition. Results revealed that proximate composion i.e. moisture, 1000- kernel weight, crude protein, crude fat, ash, crude fiber and total carbohydrates of sorghum varieties differed significantly (P<0.01) and the results of the crude protein ranged from 9.333-16.030%, crude fat 2.602 to 4.627%, crude fiber 4.850-8.963%, ash 1.241-1.883, moisture content 6.767-12.839, 1000 kernel seed weight 22.263-42.626, and total carbohydrate 66.834 to 78.744%. This study showed that the physicochemical composition of the 10 selected sorghum varieties of Ethiopia was significantly different from one variety to another variety and different varieties are different in physicochemical profile.Abstract: Sorghum is an important cereal crop used as human a staple food grain in many semi-arid and tro pical areas of the world, notably is Sub-Saharan Africa and Asian continents by approximately 500 million people due to its good agronomic properties in harsh environment. It is known that sorghum is a gluten-free cereal used as ground flour and it is a ...Show More